Melanoma is the 4th most common cancer diagnosed in Australia. Advanced melanoma frequently spreads to other organs and can acquire resistance to anti-melanoma treatments, making it fundamentally incurable. I am focused on investigating the mechanisms underlying melanoma disease progression. I will achieve this by comparing the biological nature of melanoma cells at different stages of disease and therapy-resistance to identify new targets for the more effective treatment of patients with melano ....Melanoma is the 4th most common cancer diagnosed in Australia. Advanced melanoma frequently spreads to other organs and can acquire resistance to anti-melanoma treatments, making it fundamentally incurable. I am focused on investigating the mechanisms underlying melanoma disease progression. I will achieve this by comparing the biological nature of melanoma cells at different stages of disease and therapy-resistance to identify new targets for the more effective treatment of patients with melanoma.Read moreRead less
Maternal And Neonatal Vaccination - How Early Can We Protect Infants?
Funder
National Health and Medical Research Council
Funding Amount
$196,331.00
Summary
Currently, only hepatitis B vaccine is routinely given at birth and for all other vaccines the earliest recommended administration is at 6 weeks old. This is too late to protect infants against pertussis and the most severe cases (hospitalisation or death) occur before 4 months. This research aims to assess if birth pertussis vaccination can protect infants earlier, measure the longevity of immunity following birth hepatitis B vaccination and examine the potential role for maternal vaccination
A Practical New Method Of Measuring Population Salt Intake
Funder
National Health and Medical Research Council
Funding Amount
$327,193.00
Summary
The World Health Organization has set a target for member countries to reduce salt intake by 30% by 2025. Key to this is measurement of population salt intake. Collection of 24-hour urine samples is the gold standard used to estimate salt intake but this method is burdensome. Collection of a single urine sample is an alternative method. This project will bring together all of the available data worldwide to assess the reliability of using a single urine sample to measure population salt intake.
Stroke Outcomes Following Catheter Ablation In Patients With Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$408,353.00
Summary
Atrial fibrillation is the most common heart rhythm disorder encountered in clinical practice. It is an irregular rhythm that predisposes individuals to stroke. Recently, catheter ablation has been shown to be successful in controlling this irregular rhythm. My research will investigate whether this treatment will decrease the risk of stroke in patients with atrial fibrillation by following a large cohort of patients after catheter ablation compared to those who have not underwent the procedure.
The first kernels of cardiovascular disease begin very early in life; in the womb and early infancy. These early indications are known to track into adulthood, eventually resulting in diseases such as heart attacks. Dr Huang has found that childhood obesity, high blood pressure, cholesterol and a "prediabetes" profile, cluster together and additionally are associated with many factors in the womb and first few years of life. She investigates how to give babies the optimal healthy start.