Epilepsy: Molecular Basis And Mechanisms In The Era Of Functional Genomics
Funder
National Health and Medical Research Council
Funding Amount
$12,062,533.00
Summary
The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these stud ....The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these studies. This will include extensive laboratory studies, including the development of mice with the exact mutations that we find in the human condition. Stateof-the-art imaging techniques with magnetic resonance and positron emission tomography are used in human subjects to further understand the effects of the mutations on the structure and function of the brain. This will allow deep understanding of how seizures develop and may lead to new diagnostic methods and treatments. The laboratory and clinical aspects of the research are tightly integrated in this internationally leading collaborative program.Read moreRead less
Protecting Critical Transport Infrastructure using Hybrid Approaches for Interference and Spoofer Detection and Localisation. Modern infrastructure increasingly relies on the positioning and timing capabilities provided by the Global Navigation Satellite Systems (GNSS). GNSS signals, however, are vulnerable to interference and spoofing attacks. This vulnerability is aggravated as satellite navigation becomes more central to the operation of airports, ports, railways, and communications systems. ....Protecting Critical Transport Infrastructure using Hybrid Approaches for Interference and Spoofer Detection and Localisation. Modern infrastructure increasingly relies on the positioning and timing capabilities provided by the Global Navigation Satellite Systems (GNSS). GNSS signals, however, are vulnerable to interference and spoofing attacks. This vulnerability is aggravated as satellite navigation becomes more central to the operation of airports, ports, railways, and communications systems. Building on from earlier work by University of New South Wales, University of Adelaide and GPSat Systems, this project aims to create a system for locating interference and spoofers to GNSS of any power in real time, providing layered monitoring and reactive mitigation solutions against interference and spoofing attacks.Read moreRead less
The Risks And Benefits Of Contemporary Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$493,530.00
Summary
The number of hip replacements undertaken in Australia is steadily increasing. The most common complications of hip replacements are dislocation and loosening due to bone loss around the implant, requiring complex and expensive revision surgery. This study will investigate the incidence of dislocation and, using a new diagnostic imaging technique, the incidence and amount of bone loss around a relatively new prosthetic material, the outcomes of which are not known despite its increasing use.