Nocturnin: A Post-transcriptional Regulator Of Circadian Fat Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$574,696.00
Summary
Our metabolism is aligned with the 24-hour rotation of the earth in what is termed the circadian clock. Being misaligned to this clock explains jetlag and the poor health associated with shift-workers. For example, whether fat is utilised or stored depends on the time of day. This study aims to investigate the post-transcriptional mechanisms that underpin the rhythmic changes that occur throughout our bodies to ensure that our metabolism is matched to our environment.
The 3’ UTR Codes That Control MRNA Translation In Development
Funder
National Health and Medical Research Council
Funding Amount
$609,281.00
Summary
We are the product of an exquisite programme that controls when and where genes are turned on and off, over time, from a single cell to adulthood. This project concerns codes that regulate this programme with a focus on early development, the germline and neuronal cells. Using the same technology that now allows individuals to sequence their own genome, we will study an aspect of this timing in model organisms having genetic lesions in specific pathways that relate also to human health and disea ....We are the product of an exquisite programme that controls when and where genes are turned on and off, over time, from a single cell to adulthood. This project concerns codes that regulate this programme with a focus on early development, the germline and neuronal cells. Using the same technology that now allows individuals to sequence their own genome, we will study an aspect of this timing in model organisms having genetic lesions in specific pathways that relate also to human health and disease.Read moreRead less
Role Of Sirtuins In The Regulation Of The Carcinogen Metabolising Arylamine N-acetyltransferases
Funder
National Health and Medical Research Council
Funding Amount
$327,324.00
Summary
This project will investigate critical biochemical pathways that regulate metabolic differences in normal and cancer cells. By understanding how these processes differ, novel approaches for detecting and managing cancer cell proliferation in humans may be achievable.
Antibiotic Tolerance And Small RNA Networks In Staphylococcus Aureus
Funder
National Health and Medical Research Council
Funding Amount
$521,559.00
Summary
Treatment of MRSA is restricted to last line antibiotics and treatment failure is associated with an intermediate tolerance to vancomycin. Regulatory molecules termed small RNA mediate responses to antibiotic challenge but their functions are poorly understood. This proposal will profile sRNA function to understand how they adapt S. aureus to antibiotic challenge. A molecular understanding of vancomycin-tolerance will inform development of diagnostics and treatment strategies.
Are Healthcare Interventions Exacerbating Alzheimer's Disease (AHEAD)
Funder
National Health and Medical Research Council
Funding Amount
$709,803.00
Summary
The AHEAD Study will assess the impact of anaesthesia and surgery on cognitive function in patients with Mild Cognitive Impairment or mild Alzheimer's Disease. Such effects have not been established. With an ageing population being increasingly exposed to healthcare procedures requiring anaesthesia or sedation, any negative impact needs to be identified so that therapeutic decisions may be informed and future research appropriately targeted.
Alternative Splicing- A Regulatory Mechanism Determining Self-renewal And Pluripotency Of ES And IPS Cells
Funder
National Health and Medical Research Council
Funding Amount
$664,650.00
Summary
Stem cells hold great promise in cell replacement therapies and may provide models to study human diseases and to screen new pharmaceuticals. For successful future therapeutic applications, a deeper understanding of the molecular mechanisms governing the behavior of stem cells is crucial. In this proposal we will investigate the role of alternative splicing in the control of the fundamental properties of stem cells, and identify target RNAs and gene expression networks regulated by splicing fact ....Stem cells hold great promise in cell replacement therapies and may provide models to study human diseases and to screen new pharmaceuticals. For successful future therapeutic applications, a deeper understanding of the molecular mechanisms governing the behavior of stem cells is crucial. In this proposal we will investigate the role of alternative splicing in the control of the fundamental properties of stem cells, and identify target RNAs and gene expression networks regulated by splicing factors.Read moreRead less