Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate impr ....Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate improved technology for early diagnosis of impairment in microvascular flow relevant to muscle insulin resistance and novel therapeutics that improve muscle microvascular blood flow applicable to the treatment of diabetes.Read moreRead less
Inherited determinants of cancer aetiology. Family history of cancer is a strong risk factor for many cancers. This project will aim to identify inherited factors influencing risk of developing cancer and those factors influencing the course of the disease and outcomes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452281
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessmen ....Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessment of adaptation to physical training and (iii) the development of therapeutic agents used to treat diabetes. We anticipate improved technology that is fully characterized and novel therapeutics that improve microvascular blood flow.Read moreRead less
Self-destructing CRISPR-constructs For Targeted Genome Editing In The Retina.
Funder
National Health and Medical Research Council
Funding Amount
$679,926.00
Summary
Despite the identification of specific mutations causing many inherited retinal dystrophies, all of these conditions are currently untreatable. We have established gene-editing techniques and have developed a novel mouse model, which will serve as a robust platform for testing different techniques of gene editing in the retina. No other group in the world is known to be using this platform for gene editing and our work will expedite the clinical translation of this technology.
Towards a Legal and Institutional Framework for the Conservation and Sustainable Use of High Seas Biodiversity. The legal and institutional challenges required to manage high seas biodiversity have been identified by the United Nations as one of the greatest challenges in oceans management in the 21st century. This Project will research the legal and institutional factors at the national, regional and international levels that militate against conservation of marine biodiversity beyond nation ....Towards a Legal and Institutional Framework for the Conservation and Sustainable Use of High Seas Biodiversity. The legal and institutional challenges required to manage high seas biodiversity have been identified by the United Nations as one of the greatest challenges in oceans management in the 21st century. This Project will research the legal and institutional factors at the national, regional and international levels that militate against conservation of marine biodiversity beyond national jurisdictions and develop practical actions to address the problems identified. The outcome of the Project will be the development of a policy oriented methodology to guide the legal and policy developments on high seas biodiversity conservation at the international and national levels.Read moreRead less
Impacts of climate change on biogenic habitat-forming seaweeds in south east Australia. Seaweed-based systems on rocky reefs in south east Australia support high levels of biodiversity, endemism and economic activity (fisheries). We will provide important insight into how climate change is likely to affect the key habitat-forming seaweeds in this system, and a first assessment of how other marine species will respond to any shift in abundance of the habitat-forming seaweeds. These predictions ar ....Impacts of climate change on biogenic habitat-forming seaweeds in south east Australia. Seaweed-based systems on rocky reefs in south east Australia support high levels of biodiversity, endemism and economic activity (fisheries). We will provide important insight into how climate change is likely to affect the key habitat-forming seaweeds in this system, and a first assessment of how other marine species will respond to any shift in abundance of the habitat-forming seaweeds. These predictions are critical if human adaptation to effects of climate change are to be proactive and not reactive. We will also test a basic assumption of most bio-climate envelope models that are the basis of many current predictions of the effect of climate change on species distributions. The project will provide the basis for training of two PhD students.Read moreRead less
Dark survival in the polar winter. There is strong public interest in both the Arctic and Antarctica and global climate change. By better understanding how these polar ecosystems function in winter and the likely effects of increasing temperatures we will be able to keep the public informed on likely impacts. There are large fishing industries in the Arctic and growing finfish and krill fisheries in the Southern Ocean. This project will contribute to a better understanding of how these stocks wi ....Dark survival in the polar winter. There is strong public interest in both the Arctic and Antarctica and global climate change. By better understanding how these polar ecosystems function in winter and the likely effects of increasing temperatures we will be able to keep the public informed on likely impacts. There are large fishing industries in the Arctic and growing finfish and krill fisheries in the Southern Ocean. This project will contribute to a better understanding of how these stocks will be affected (together with seals, penguins and whales) and how they should be managed to ensure sustainable fisheries and maximum biodiversity.Read moreRead less
Reducing skeletal malformations in cultured marine fish using gene expression, improved nutrition and advanced system operation. Reducing malformations in farmed fish will benefit the Australian economy and society by providing greater quantities of cheaper, higher quality fish. Increased farmed fish production, currently worth ~$300 million p.a., will increase exports and decrease imports (currently ~50% of all Australian consumed fish). To benefit are the important regional farming operations ....Reducing skeletal malformations in cultured marine fish using gene expression, improved nutrition and advanced system operation. Reducing malformations in farmed fish will benefit the Australian economy and society by providing greater quantities of cheaper, higher quality fish. Increased farmed fish production, currently worth ~$300 million p.a., will increase exports and decrease imports (currently ~50% of all Australian consumed fish). To benefit are the important regional farming operations in QLD, NSW, SA, NT, TAS and WA. In particular, the largest industry in Tasmania will profit by having a viable new species to farm (striped trumpeter) reducing risk due to climate change and global oversupply of salmon. Another important benefactor will be the rapidly expanding yellowtail kingfish industry. Read moreRead less
Efficacy Of Education And Advice Delivered By Text Message To Aid Smoking Cessation
Funder
National Health and Medical Research Council
Funding Amount
$538,395.00
Summary
A high proportion of smokers indicate a desire to stop smoking and report having made attempts to quit. However, most attempts are not successful and new methods are needed to support motivated smokers and improve success rates. This project evaluates the use of text messages to deliver advice and support to smokers motivated to stop smoking. We aim to understand if and how this promosing new intervention helps smokers to quit.