Ehanced Hydrodynamic Fractionation of Particles. The coal industry, which is a major contributor to the Australian economy, urgently needs a new washability method following its decision to abandon the existing laboratory standard. The existing method relies on the use of heavy organic liquids which are known to be toxic to human health. The 'water-based' approach proposed in this study overcomes the problem of risk to human health, thus benefiting Australian workers, the immediate industry, and ....Ehanced Hydrodynamic Fractionation of Particles. The coal industry, which is a major contributor to the Australian economy, urgently needs a new washability method following its decision to abandon the existing laboratory standard. The existing method relies on the use of heavy organic liquids which are known to be toxic to human health. The 'water-based' approach proposed in this study overcomes the problem of risk to human health, thus benefiting Australian workers, the immediate industry, and wider community. New separation technologies that could benefit the minerals industries and other key industries should follow. The project will also result in the education and training of two postgraduate students, and the advancement of two postdoctoral researchers in this area of industry. Read moreRead less
Hydrophobic particle recovery using permeable hydrophobic media. This project aims to solve an intractable problem in froth flotation. Bubbles will be replaced by permeable, hydrophobic media, minimising the viscous hydrodynamic resistance that limits ultrafine particle recovery. The project expects to generate new knowledge relating the efficacy of the novel media to its underlying physical structure, composition, geometry, and interfacial structure. Expected outcomes include a framework for de ....Hydrophobic particle recovery using permeable hydrophobic media. This project aims to solve an intractable problem in froth flotation. Bubbles will be replaced by permeable, hydrophobic media, minimising the viscous hydrodynamic resistance that limits ultrafine particle recovery. The project expects to generate new knowledge relating the efficacy of the novel media to its underlying physical structure, composition, geometry, and interfacial structure. Expected outcomes include a framework for developing alternative, highly permeable, hydrophobic media, and new high performance separation technologies. This is expected to benefit large scale, low-cost, ultrafast processing of particulate suspensions in mineral processing and waste water treatment.Read moreRead less
Surface characteristics and hydrodynamics in detachment of coarse particles. Froth flotation is widely used for separating coal and minerals from the gangue. The largest particles that can be floated in the industry are 10 times smaller than the particles that can be floated under quiescent conditions. This project aims to better understand and quantify the detachment of large particles from the bubble surface. It aims to develop innovative modelling and experimental approaches to examine the ef ....Surface characteristics and hydrodynamics in detachment of coarse particles. Froth flotation is widely used for separating coal and minerals from the gangue. The largest particles that can be floated in the industry are 10 times smaller than the particles that can be floated under quiescent conditions. This project aims to better understand and quantify the detachment of large particles from the bubble surface. It aims to develop innovative modelling and experimental approaches to examine the effect of particle surface characteristics and hydrodynamic conditions on coarse particle detachment and flotation. New ways to save energy by floating coarse composite particles are proposed to be developed. This research is at the forefront of flotation science and technology, and is expected to deliver significant outcomes to the mining industry.Read moreRead less
Antagonist Of Corticotrophin Releasing Hormone As Therapeutic Agents For The Prevention Of Premature Birth In Humans
Funder
National Health and Medical Research Council
Funding Amount
$376,650.00
Summary
In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow ....In developed countries the most common cause of the death of a newborn baby is premature delivery. Pre-term delivery remains the greatest cause of neonatal mortality in the western world and a major consumer of health dollars (approx. $5-7B per year in the US alone). However, a delay in the onset of labour from 20 to 25 weeks has been shown to result in a 55% greater probability of infant survival (550 fewer deaths per 1000). This project will allow: The development of new drugs that will allow the extension of pregnancy term The development of protocols that will in turn reduce neonatal mortality. Additionally we believe that these new agents will be useful in preventing the onset of labour after fetal surgery. Currently there are no effective treatments capable of substantially changing delivery dates. Available therapeutics delay the onset of labour, at best, 24 hours. However, recent exciting results from our laboratories show that rising concentrations of the placental peptide Corticotrophin Releasing Hormone (CRH) are associated with the onset of labour. Further, we have also delayed the onset of labour in pregnant sheep by infusing a relatively insoluble CRH antagonist into the sheep fetus. Labour commenced ONLY AFTER the drug was withdrawn from the mother. This project builds upon an interdisciplinary team: medicinal chemists, molecular modellers, pharmacologists and endocrinologists, to further develop an exciting Australian discovery. Successful completeion of this research will, for the first time, allow the control of pregnancy duration MAXIMISING the benefits to mother and child, reducing mortality and later life morbidities typically associated with premature birth.Read moreRead less
The Intrarenal Renin Angiotensin System (RAS) In Indigenous Women: An Early Indicator Of Renal Dysfunction In Women At Risk Of Pregnancy Complications
Funder
National Health and Medical Research Council
Funding Amount
$645,358.00
Summary
Indigenous women are twice as likely to have low birth weight babies compared to non-Indigenous women and 2.5 times as likely to develop preeclampsia, possibly because they have a much greater incidence of chronic kidney disease, predisposing them to these pregnancy outcomes. We have found a new, sensitive marker of early stage renal dysfunction in pregnancy that could be useful for detecting early stage renal disease and which is indicative of an increased risk of adverse pregnancy outcome.
Improved Formulations Of Anti-cancer Agents 5-Fluorouracil And Oxaliplatin Using Excipient Technology
Funder
National Health and Medical Research Council
Funding Amount
$202,973.00
Summary
Chemotherapy plays a key role in cancer treatment, however, problems persist with severe adverse toxic effects. Combinations of anti-cancer agents give better results, but these agents still have major negative effects, for example, on veins and peripheral nerves and they must be given separately. We have developed a novel, all-in-one formulation of Oxaliplatin with 5-Fluorouracil and Leucovorin, with the potential for fewer toxic effects and improved patient care.
Development of a Model Relating Aggregate Properties with Aggregation Conditions for Design and Control Purposes. The project aims to understand the role of shear and other important parameters in the aggregation of nano- and micron-sized particles through fundamental studies on different particulate systems and shear environments. The knowledge will be used to develop an engineering model relating the floc properties to system conditions, thus allowing the utilisation of experimental data to fu ....Development of a Model Relating Aggregate Properties with Aggregation Conditions for Design and Control Purposes. The project aims to understand the role of shear and other important parameters in the aggregation of nano- and micron-sized particles through fundamental studies on different particulate systems and shear environments. The knowledge will be used to develop an engineering model relating the floc properties to system conditions, thus allowing the utilisation of experimental data to full-scale operations without eschewing their relevance. Project outcomes include a comprehensive guideline to set optimum conditions required to generate flocs with desirable properties for control and design purposes, with applicability extending from solid-liquid separation to nano-material synthesis, and various processes involving particle aggregation.Read moreRead less
Flotation in high salt concentration: resolving critical knowledge gaps relating the ion effect on bubble production and behavior. Flotation separation of coal and mineral particles by attaching to rising air bubbles is significantly affected in high salt concentration but its exact mechanism still remains unclear. This project employs state-of-the-art surface sensitive spectroscopy and modeling tools to investigate how salt ions influence drainage and rupture of liquid films between two bubbles ....Flotation in high salt concentration: resolving critical knowledge gaps relating the ion effect on bubble production and behavior. Flotation separation of coal and mineral particles by attaching to rising air bubbles is significantly affected in high salt concentration but its exact mechanism still remains unclear. This project employs state-of-the-art surface sensitive spectroscopy and modeling tools to investigate how salt ions influence drainage and rupture of liquid films between two bubbles, and bubble production and behaviour relevant to the flotation processes. The research will develop better water use for coal and mineral flotation to reduce reagent usage and environmental impacts of water pollution. The project will contribute significantly to knowledge advancement in the coal and mineral industry.Read moreRead less
The role of floc structure in the formation of sediments and filter cakes. The project aims to understand at a fundamental level if and in what way the fractal structure of aggregates of fine particles is preserved when forming sediments and filter cakes. The effect of this structure on processes for separating solids and liquids is significant: each year, millions of dollars stand to be saved though more efficient filtration, and more efficient thickening of mineral slurries. Improved understan ....The role of floc structure in the formation of sediments and filter cakes. The project aims to understand at a fundamental level if and in what way the fractal structure of aggregates of fine particles is preserved when forming sediments and filter cakes. The effect of this structure on processes for separating solids and liquids is significant: each year, millions of dollars stand to be saved though more efficient filtration, and more efficient thickening of mineral slurries. Improved understanding allows intelligent design of flocculation systems to optimise the performance of downstream solid - liquid separation processes, maximising economic and environmental returns.Read moreRead less
Hydrodynamic enhancement and transformation of flotation. The purpose of this project is to address emerging challenges in coal and mineral processing associated with the steep decline in the quality of mining assets and the long term resource demands of China and India. A major advance in flotation technology is expected, leading to the highest possible product grade at a given recovery.