The unfolding story of the 2009 Adelaide heatwave: risk factors for mortality and morbidity. This project will conduct a case control study in Adelaide to explore the risk factors of extra health burden related to the 2009 heatwave. Given the prediction of more extreme heat events, this study will provide important information for policy makers and service providers to assist in the development of more resilient communities to climate change.
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Just spaces: security without prejudice in the wireless courtroom. How do jurors respond to seeing defendants in a glass cage, in a traditional wooden dock or at the Bar table? The project will examine how courtroom design shapes attitudes; and, bringing together court executives, architects and researchers, will show how flexible wireless courtrooms can meet both security and human rights standards.
Pushing AR Toward Better Outcomes In Breast And Prostate Cancers
Funder
National Health and Medical Research Council
Funding Amount
$998,754.00
Summary
Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives ....Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
A Randomised Controlled Trial (RCT) Of Azithromycin Versus Doxycycline For The Treatment Of Rectal Chlamydia Infection In Men Who Have Sex With Men.
Funder
National Health and Medical Research Council
Funding Amount
$797,906.00
Summary
Rectal chlamydia is very common among gay men; it can exist for long periods without symptoms leading to ongoing transmission. Azithromycin (1 gram single dose) or 7 days doxycycline (100mg twice daily) are the two recommended treatments globally. But, there is concern about rectal chlamydia treatment with reports of up to 22% failure following azithromycin. We will conduct a randomised trial to compare these treatments for rectal chlamydia and determine which drug works better.
The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early ....The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early in life determines sensitivity to pain in adult life. In doing so, this research offers a new theoretical explanation for the ontogeny of pain and may begin to account for the many forms of chronic pain that are currently not only unexplainable from current pain theory, but difficult to manage clinically.Read moreRead less
The Cambrian Population Explosion of Arthropods in Australia: Ediacaran origins, evolution and biodiversity. This project addresses key questions on the origin and diversification of life, by investigating the evolution of the most important fossil group (arthropods) across arguably the most important event after the origin of life (the Cambrian explosion of macroscopic life). It will also excavate, promote and conserve two key geological resources of national importance, in the Flinders Ranges ....The Cambrian Population Explosion of Arthropods in Australia: Ediacaran origins, evolution and biodiversity. This project addresses key questions on the origin and diversification of life, by investigating the evolution of the most important fossil group (arthropods) across arguably the most important event after the origin of life (the Cambrian explosion of macroscopic life). It will also excavate, promote and conserve two key geological resources of national importance, in the Flinders Ranges and Kangaroo Island. Also, it will lead to increased knowledge of the palaeoecology and geology of the economically-important Adelaide geosyncline, and benefit rural SA communities through ecotourism, a rural schools education program, and public outreach.Read moreRead less
How climate-resilient are our temperate fisheries species? This project assesses the resilience of our temperate fisheries species to climate change. Using natural warming hotspots and volcanic CO2 vents we study populations of fisheries species that are already pre-adapted to future climate, and therefore could act as key populations for replenishment of future fisheries stocks. An innovative and interdisciplinary approach combines the ecology, genetics, behaviour, and physiology of fisheries s ....How climate-resilient are our temperate fisheries species? This project assesses the resilience of our temperate fisheries species to climate change. Using natural warming hotspots and volcanic CO2 vents we study populations of fisheries species that are already pre-adapted to future climate, and therefore could act as key populations for replenishment of future fisheries stocks. An innovative and interdisciplinary approach combines the ecology, genetics, behaviour, and physiology of fisheries species to evaluate their climate resilience. An advanced food web model will be developed to forecast changes to fisheries production in a future world. This provides a much-improved forecast of climate adaptation and managing future biodiversity and fisheries species through resilient genes and populations.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less