The Role Of Interleukin-21 In The Pathogenesis Of Autoimmune Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$489,060.00
Summary
Interleukin-21 (IL-21) is a soluble protein that is produced by cells enabling them to communicate with other cells. IL-21 helps cells to clear viruses and bacteria from the body. However, our studies show that IL-21 also generates T cells that destroy beta cells and cause diabetes. IL-21 is produced at abnormally high levels in an important murine model of spontaneous type-1 diabetes (T1D) and if we block IL-21 we prevent diabetes. This projects' aims assess IL-21 as therapeutic target for T1D.
Discovery And Validation Of Alzheimer�s Disease Biomarkers In Human Plasma
Funder
National Health and Medical Research Council
Funding Amount
$365,126.00
Summary
With life expectancy increasing Alzheimer�s disease (AD) poses a rising medical and socioeconomic challenge, emphasising the need for the development of prevention and treatment strategies. Such strategies will be most effective if administered early in the disease process, making early diagnosis critical to their success. The identification of biomarkers in this project, which are altered during the development of AD, will lead to the development of such a means to diagnosis AD at an early stag ....With life expectancy increasing Alzheimer�s disease (AD) poses a rising medical and socioeconomic challenge, emphasising the need for the development of prevention and treatment strategies. Such strategies will be most effective if administered early in the disease process, making early diagnosis critical to their success. The identification of biomarkers in this project, which are altered during the development of AD, will lead to the development of such a means to diagnosis AD at an early stage, when interventions will have the most impact.Read moreRead less