A pressure pulse may be felt at the wrist with every heart beat. New technology allows the analysis of this pulse and provides information that may help doctors make decisions about a patients risk related to blood pressure as well as the effect of drug treatment. The research aims to determine the clinical significance of pressure pulse analysis at rest and during light exercise. It is expected that the new technology will improve the way people with high blood pressure are treated.
Ultrasonic Blood Pressure Measurement On Implanted Biomedical Surfaces
Funder
National Health and Medical Research Council
Funding Amount
$170,250.00
Summary
The project would develop a prototype device reporting blood pressure on a biomedical implant surface. The device would extract data in real time from a standard ultrasound scanner that images the implant. The School of Mathematical Sciences at Monash University will be contracted to develop this ultrasound pressure sensor.
Renal AT2R Are A Therapeutic Target For The Treatment Of Hypertension In Women
Funder
National Health and Medical Research Council
Funding Amount
$605,939.00
Summary
Being female is associated with better renal function, resistenace to renal injury and hypertension, but it is not understood why. Our work demonstrates that women have more angiotensin type 2 receptors (AT2R) in the kidney then men. In men AT2R have been suggested to protect against hypertension and renal damage. We predict that the effects of AT2R stimulation will be greater in women and therefore the protective benefits greater.
How Does The Central Respiratory Generator Amplify Sympathetic Activity In Hypertension?
Funder
National Health and Medical Research Council
Funding Amount
$290,113.00
Summary
High blood pressure causes many life-threatening cardiovascular diseases, including heart failure and stroke. The cause of most high blood pressure is not known. Using an animal model of high blood pressure we have shown that an interaction, in the brain, between the nerve pathways that generate respiratory activity and regulate blood pressure is altered. This occurs early in life and our evidence strongly suggests this may be a cause of high blood pressure.
Respiratory Modulation Of RVLM Premotor Neurons: Role In The Sympathetic Over-activity Of Hypertension.
Funder
National Health and Medical Research Council
Funding Amount
$338,605.00
Summary
Hypertension is a common health disorder in all societies and is a major risk factor for the development of life threatening cardiovascular diseases, including heart failure and stroke. Whilst some effective therapies are available, many patients are not adequately treated or have reduced quality of life due to serious side effects. There is a great need for alternative therapies. The central nervous system is clearly involved in hypertension although the level of that involvement is not well un ....Hypertension is a common health disorder in all societies and is a major risk factor for the development of life threatening cardiovascular diseases, including heart failure and stroke. Whilst some effective therapies are available, many patients are not adequately treated or have reduced quality of life due to serious side effects. There is a great need for alternative therapies. The central nervous system is clearly involved in hypertension although the level of that involvement is not well understood- i.e. is it a causal factor or just a contributor to the maintenance of established hypertension? The experiments outlined in this application are based on the observation that modulation of nervous activity to blood vessels is more influenced by the respiratory system in people with high blood pressure, than in normotensive people. We aim to test whether this increased respiratory modulation might be involved in the generation of the high blood pressure.Read moreRead less
A Randomised Controlled Trial Of CPAP Versus Oral Appliance In Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$416,155.00
Summary
Obstructive sleep apnoea (OSA) is a very common disorder, affecting approximately 25% of women and 9% of men in the middle-aged workforce . It is characterised by repetitive, complete or partial closure of the throat passage during sleep, resulting in sleep disturbance and low oxygen levels. When associated with symptoms, termed Obstructive Sleep Apnoea Syndrome, it occurs in 4% of men and 2% of women in middle age. OSA is recognised as a serious public health problem. Continuous Positive Airway ....Obstructive sleep apnoea (OSA) is a very common disorder, affecting approximately 25% of women and 9% of men in the middle-aged workforce . It is characterised by repetitive, complete or partial closure of the throat passage during sleep, resulting in sleep disturbance and low oxygen levels. When associated with symptoms, termed Obstructive Sleep Apnoea Syndrome, it occurs in 4% of men and 2% of women in middle age. OSA is recognised as a serious public health problem. Continuous Positive Airway Pressure is the gold standard treatment, and has been demonstrated to produce major health benefits. However, there is growing evidence supporting the use of oral appliances to treat OSA, which are potentially simpler to use. It is thought that these work by enlarging the throat passage. Recent practice guidelines recommend their use as a first line treatment for mild to moderate OSA. The aim of this project is to directly compare the health benefits achievable with these therapies, taking into account patient compliance and preference, and will assist in the development of protocols for the use of these treatments in clinical practice.Read moreRead less