We will conduct a survey of respiratory symptoms, lung function, smoking status, occupational exposures, and other risk factors among 3200 people aged 40 years and over living in five Australian communities: Melbourne, Sydney, Tasmania, Busselton (WA), and the Kimberley region (WA). In the Kimberley we will survey 400 Aboriginal people and 400 non-Aboriginal people. We will use a survey methodology that has been developed by an international expert panel and has been implemented in many other co ....We will conduct a survey of respiratory symptoms, lung function, smoking status, occupational exposures, and other risk factors among 3200 people aged 40 years and over living in five Australian communities: Melbourne, Sydney, Tasmania, Busselton (WA), and the Kimberley region (WA). In the Kimberley we will survey 400 Aboriginal people and 400 non-Aboriginal people. We will use a survey methodology that has been developed by an international expert panel and has been implemented in many other countries (in North and South America, Asia, and Europe). This study will provide the first nationally-representative information on the burden of chronic obstructive pulmonary disease (COPD) and the opportunities for health gain by improving the management of this illness. In Australia, COPD is a relatively silent and under-recognised disease but nevertheless is the third most important contributor to the burden of disease and the third leading cause of hospital admission as well as being the underlying cause of 4.2% of all deaths. The information we will collect is needed to form a basis for prevention and disease management interventions to reduce the burden of COPD, particularly among population sub-groups who are disproportionately affected, either due to greater exposure to risk factors (mainly tobacco smoking and occupation), greater susceptibility, under-recognition and under-diagnosis, or inadequate disease management. Importantly, the study will serve to raise awareness about the hazards of smoking for all Australians. By identifying target groups, prevalent exposures and management deficiencies, it will lead the way towards policy-relevant randomised controlled trials testing community-based interventions to prevent COPD and-or manage it more effectively. The information collected will help advance knowledge of the prevalence, burden and treatment of COPD that will be relevant to communities throughout the world.Read moreRead less
SCALE-C: Strategies For Hepatitis C Testing And Treatment In Aboriginal Communities That Lead To Elimination
Funder
National Health and Medical Research Council
Funding Amount
$2,175,170.00
Summary
Prevalence of hepatitis C infection within the Aboriginal population is among the highest of any identifiable population in Australia. Highly effective, direct-acting antiviral (DAA) therapy, and their listing on the PBS in 2016 has revolutionised HCV clinical management in Australia. The SCALE-C study will evaluate an established test and treat model to rapidly scale-up DAA within four Aboriginal communities to determine both impact on community prevalence and ongoing transmission.
The prevalence of asthma in Australia is amongst the highest in the world yet no trials of primary prevention have been conducted which address the most common known causative agent (housedust mite allergens) and the most common known protective factor (dietary omega-3 fatty acids). Until the effectiveness of interventions which address these factors is certain, the value of the wide array of advice given to asthmatics by various health institutions will not be known. We are applying to continue ....The prevalence of asthma in Australia is amongst the highest in the world yet no trials of primary prevention have been conducted which address the most common known causative agent (housedust mite allergens) and the most common known protective factor (dietary omega-3 fatty acids). Until the effectiveness of interventions which address these factors is certain, the value of the wide array of advice given to asthmatics by various health institutions will not be known. We are applying to continue the Childhood Asthma Prevention Study (CAPS) which has been underway since mid-1997. CAPS is a randomised controlled trial in which 616 infants at high risk of developing asthma because of a family history have been enrolled. The interventions include allergen reduction and dietary supplementation with omega-3 fatty acids. The interventions are designed to have maximum effect but be simple to implement by parents. Several measures of compliance are being collected and regular contact is maintained though telephone calls and frequent home visits. Objective and subjective measurements of exposures, atopy, diet and asthmatic symptoms are being collected at 3 month intervals and at medical assessments when the children are 18 months, 3 and 5 years old. It is essential that we continue the study until all children are aged 5 and we will be able to test conclusively whether the interventions have had a positive effect. If so, CAPS will form the basis for a nationwide public health campaign which will have the potential to reduce the incidence of childhood asthma in Australia.Read moreRead less
A Survey Of The Sexual Behaviour And Sexual Health Of Australian Prisoners
Funder
National Health and Medical Research Council
Funding Amount
$591,000.00
Summary
The Australian Study of Health and Relationships telephone survey recently reported on the sexual attitudes, knowledge, health and behaviour of over 19,000 Australians. One of the groups that was omitted from that survey was prisoners. Yet prisoners are a high-risk group for sexual ill health. Prisoners are mostly drawn from the most disadvantaged groups in society: they are more likely to be unemployed, they have less education and lower incomes than other Australians, and many suffer from mino ....The Australian Study of Health and Relationships telephone survey recently reported on the sexual attitudes, knowledge, health and behaviour of over 19,000 Australians. One of the groups that was omitted from that survey was prisoners. Yet prisoners are a high-risk group for sexual ill health. Prisoners are mostly drawn from the most disadvantaged groups in society: they are more likely to be unemployed, they have less education and lower incomes than other Australians, and many suffer from minor intellectual disabilities and-or mental illness. This proposed survey of inmates in Australian prisons will fill in this missing data. Prisoners are the forgotten population in many countries. Only a few surveys of prisoners' health have been performed. There are some surveys of sexual behaviour in particular prisons overseas, though most of them concentrate on HIV risks and do not explore the sexual lives of prisoners in the same way as the major national sex surveys in the US, the UK and France did for people living outside prison. Prison is itself a dangerous place for people's sexual health. In prison, much of the sex that occurs is not voluntary. Sexual assault in prisons can lead to serious physical injury as well as risk of sexually transmitted diseases including HIV-AIDS. Although some of these injuries can be sufficiently serious to require surgery, only a small proportion are reported to the authorities. Younger prisoners (aged 18-25) and those who are small, slightly built or gay, are at higher risk of being assaulted. This study will explore the factors surrounding sexual assault in prison and make recommendations for preventing it.Read moreRead less
Impact Of An Ivermectin Mass Drug Administration Program Against Endemic Scabies And Strongyloidiasis
Funder
National Health and Medical Research Council
Funding Amount
$1,289,786.00
Summary
Overseas studies suggest sustainable and long term benefits can be obtained through the use of ivermectin in mass drug administration programs to control parasitic infections. Our study will be a critical first step in establishing if such a program can be successful in a remote Indigenous community setting, where the disease burden from scabies and strongyloidiasis (threadworm infections) is very high.
Resilience of eucalypts to future droughts. This project aims to examine how resilient Eucalyptus species are to future droughts by combining data synthesis, manipulative experiments and modelling. Climate change is expected to increase the frequency, magnitude and duration of future droughts, with major environmental and socio-economic consequences for Australia. Current predictive capacity is extremely limited: experiments are limited in scale and cannot capture important global change interac ....Resilience of eucalypts to future droughts. This project aims to examine how resilient Eucalyptus species are to future droughts by combining data synthesis, manipulative experiments and modelling. Climate change is expected to increase the frequency, magnitude and duration of future droughts, with major environmental and socio-economic consequences for Australia. Current predictive capacity is extremely limited: experiments are limited in scale and cannot capture important global change interactions, whilst models do not represent the functional characteristics and adaptions of eucalypts. This project will develop a strong evidence- and process-based understanding to quantify the functional behaviour of drought-adapted Eucalyptus species and leverage this insight to make future model projections.Read moreRead less
Local climate changes caused by large bushfire burnt areas. This project aims to quantify the impact on local climate produced by large burnt areas after extreme bushfires. This project expects to generate new knowledge on these previously unexplored fire-scar induced changes to local climate. It will extend an innovative approach that combines satellite based earth observation with very high resolution regional climate modelling to quantify the impacts on land-atmosphere feedbacks and local cli ....Local climate changes caused by large bushfire burnt areas. This project aims to quantify the impact on local climate produced by large burnt areas after extreme bushfires. This project expects to generate new knowledge on these previously unexplored fire-scar induced changes to local climate. It will extend an innovative approach that combines satellite based earth observation with very high resolution regional climate modelling to quantify the impacts on land-atmosphere feedbacks and local climate. Expected outcomes of this project include enhanced methods to quantify local climate changes after extreme fires and their effect on vegetation recovery. This should provide significant benefits to the planning for, and management of, vegetation recovery after extreme fires.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100116
Funder
Australian Research Council
Funding Amount
$1,200,000.00
Summary
Facilities for Atmospheric Boundary Layer Evaluation and Testing. This proposal aims to establish state-of-the-art stationary and mobile facilities for atmospheric wind, dust and plume measurements with unique capability to quantify the effect of climate change, surface topography and urbanisation on near-surface microclimate where humans live. To better predict microclimate, mitigate air pollution impacts and exploit local conditions for improved urban planning and agricultural yield, high qual ....Facilities for Atmospheric Boundary Layer Evaluation and Testing. This proposal aims to establish state-of-the-art stationary and mobile facilities for atmospheric wind, dust and plume measurements with unique capability to quantify the effect of climate change, surface topography and urbanisation on near-surface microclimate where humans live. To better predict microclimate, mitigate air pollution impacts and exploit local conditions for improved urban planning and agricultural yield, high quality observations of the near-surface atmosphere at fine temporal and spatial resolutions are required. The proposed Facilities for Atmospheric Boundary Layer Evaluation and Testing (FABLET) will advance Australia’s capability to make these difficult measurements of atmospheric boundary layer.Read moreRead less
Are proposed land-based sinks for greenhouse gases resilient to climate change and natural variability? One strategy to reduce the scale of future climate change is to enhance the storage of carbon in vegetation and soils. Evidence suggests carbon stored in vegetation and soils is itself vulnerable to climate change, placing this stored carbon at risk; this project will assess this risk to advise on the reliability of using terrestrial systems as carbon sinks.
How do humans affect the nature and impacts of Australian heatwaves? This project aims to provide more accurate information on the human signal behind heatwaves and their impacts, by deriving a comprehensive approach of the detection and attribution of climate extremes. The project expects to generate robust estimates of the human signal behind high-impact events, and an innovative, versatile methodology that can be applied to any extreme event and its impacts. With the specific application to A ....How do humans affect the nature and impacts of Australian heatwaves? This project aims to provide more accurate information on the human signal behind heatwaves and their impacts, by deriving a comprehensive approach of the detection and attribution of climate extremes. The project expects to generate robust estimates of the human signal behind high-impact events, and an innovative, versatile methodology that can be applied to any extreme event and its impacts. With the specific application to Australian heatwave impacts on human health, key knowledge should support more targeted and accurate mitigation policies, minimising the strain on resources when future heatwaves occur. This should help in safeguarding future generations from deadly impacts of heatwaves.Read moreRead less