Does Pneumococcal Vaccination Protect Against Cardiovascular Disease? A Randomised Placebo-controlled Double Blind Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,849,245.00
Summary
Australian researchers have set up a novel multi-centre trial to investigate the effects of the pneumococcal vaccination in reducing heart attacks and stroke. People aged 55 to 61 from 6 sites around Australia will be invited to participate in the study. The selected participants will attend a clinic in their area and will be randomly given the pneumococcal vaccine or a placebo vaccine. Outcomes on the expected 6000 participants will be ascertained by health record linkage with government databa ....Australian researchers have set up a novel multi-centre trial to investigate the effects of the pneumococcal vaccination in reducing heart attacks and stroke. People aged 55 to 61 from 6 sites around Australia will be invited to participate in the study. The selected participants will attend a clinic in their area and will be randomly given the pneumococcal vaccine or a placebo vaccine. Outcomes on the expected 6000 participants will be ascertained by health record linkage with government databases after 4 years.Read moreRead less
Randomised Controlled Trial Of Multimedia Patient Education Approaches To Preventing In-hospital Falls
Funder
National Health and Medical Research Council
Funding Amount
$524,137.00
Summary
In hospital falls are one of the most frequently occurring adverse events in Australian hospitals. They are the cause of considerable patient morbidity, stress to family members and care givers, and health care resource use. However, there are many potential causes of in-hospital falls which has made minimising them a difficult task for hospitals around the country. Recent evidence has indicated that a patient intervention strategy is useful for preventing in-hospital falls as a part of a multi- ....In hospital falls are one of the most frequently occurring adverse events in Australian hospitals. They are the cause of considerable patient morbidity, stress to family members and care givers, and health care resource use. However, there are many potential causes of in-hospital falls which has made minimising them a difficult task for hospitals around the country. Recent evidence has indicated that a patient intervention strategy is useful for preventing in-hospital falls as a part of a multi-factorial falls prevention program. This research aims to investigate the effectiveness and economic benefit of two approaches to providing patient education for the prevention of in-hospital falls. Patients at high risk for falls will be recruited from the Princess Alexandra Hospital and be randomly allocated to either a DVD + 4 sessions of face-to-face education with an occupational therapist program, to a DVD alone education program, or to a usual care with no additional education control condition. Patients will be followed up until their discharge from hospital and the number of in-hospital falls they incur will be compared between groups. It is expected that both the DVD + 4 sessions of face-to-face education with an occupational therapist program, to a DVD alone education program will be effective in reducing falls and that the DVD alone education program will demonstrate the greater cost-effectiveness in reducing falls. Stemming from this research, it is anticipated that a cost-effective resource for preventing in-hospital falls will be developed and evaluated such that it can be used in hospitals Australia wide.Read moreRead less
Case-control Studies Of Completed And Attempted Suicide In Young People In NSW
Funder
National Health and Medical Research Council
Funding Amount
$819,000.00
Summary
Youth suicide rates have been increasing dramatically over the last three to four decades. The causes and determinants of these suicide rate changes remain unclear, as do the causes and determinants of the suicides themselves. Despite a range of risk factors being identified by researchers, predicting an individual suicide is difficult due to the range of factors involved and the complex interactions between them. This study will investigate associations between individual and environmental fact ....Youth suicide rates have been increasing dramatically over the last three to four decades. The causes and determinants of these suicide rate changes remain unclear, as do the causes and determinants of the suicides themselves. Despite a range of risk factors being identified by researchers, predicting an individual suicide is difficult due to the range of factors involved and the complex interactions between them. This study will investigate associations between individual and environmental factors for both completed suicides and suicide attempts in young people aged 18-34 years living in NSW. The study will be undertaken in Sydney, Newcastle and in identified rural areas. The study is embedded in existing treatment, counselling and support services and will aid their improvement and augmentation. Cases of suicide and attempted suicide will be compared with community controls, and also completed suicides with attempted suicides, to identify potentially modifiable risk factors associated with suicidal behaviour. This will provide more comprehensive information relating to how various risk factors interact and influence suicidal behaviour, including in rural areas with significant Aboriginal and Torres Strait Islander communities. Information from this study will improve prevention initiatives and assist with community strategic development and provide evidence to enhance current health service and coronial interventions.Read moreRead less
Mechanisms Of Escape From Progesterone-induced Suppression: Role In Normal And Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$547,970.00
Summary
Prematurity caused by preterm birth is the leading cause of death and disease among newborns in Australia. Here we will define how the length of pregnancy is determined by the opposing actions of progesterone, which maintains pregnancy, and prostaglandins, which induce labour. We will demonstrate the mechanism by which the actions of the two hormones are balanced in normal pregnancy and disrupted in preterm labour. We will show that preterm birth can be prevented by correcting the disorder.
Treatment Of Asymptomatic Candidiasis In Pregnant Women For The Prevention Of Preterm Birth: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,120,373.00
Summary
Being born too early is a leading cause of perinatal death and morbidity. This trial seeks to determine whether screening for and treating candidiasis in pregnancy reduces the risk of this serious health problem. The trial will discover whether a simple treatment in pregnancy can reduce preterm birth. If positive, the results will be relevant to the management of every pregnancy.