mTOR signalling in serous ovarian cancer. Serous ovarian cancer is the most aggressive and lethal gynaecological cancer in Australian women. Activation of Mammalian Target of Rapamycin (mTOR) is frequently observed and associated with poor prognosis in ovarian cancer patients. However, the mechanisms dysregulating mTOR in the pathogenesis of ovarian cancer are unknown. In preliminary studies, deletion of genes regulating mTOR signalling in up to 60 per cent of human serous ovarian cancer patien ....mTOR signalling in serous ovarian cancer. Serous ovarian cancer is the most aggressive and lethal gynaecological cancer in Australian women. Activation of Mammalian Target of Rapamycin (mTOR) is frequently observed and associated with poor prognosis in ovarian cancer patients. However, the mechanisms dysregulating mTOR in the pathogenesis of ovarian cancer are unknown. In preliminary studies, deletion of genes regulating mTOR signalling in up to 60 per cent of human serous ovarian cancer patients was observed. This project will provide mechanistic details of involvement of mTOR signalling in pathogenesis of the serous ovarian carcinoma, and develop a rationale for targeting mTOR pathway in these patients. Read moreRead less
Innovative solutions to primary care management of back pain. Each year in Australia over $1billion is spent on low back pain treatment. Part of the reason for this massive expenditure is that back pain is extremely common. Most existing treatments involve highly skilled practitioners and considerable cost to the patient. This program of research will look at evaluating simple, low-cost care for patients with back pain. It will also consider the delivery of back pain care by community pharmacist ....Innovative solutions to primary care management of back pain. Each year in Australia over $1billion is spent on low back pain treatment. Part of the reason for this massive expenditure is that back pain is extremely common. Most existing treatments involve highly skilled practitioners and considerable cost to the patient. This program of research will look at evaluating simple, low-cost care for patients with back pain. It will also consider the delivery of back pain care by community pharmacists, an approach not previously evaluated. Prevention of recurrent back pain will also be studied. Such methods of delivering care will provide enormous savings to the health system while still ensuring best practice care for the patient.Read moreRead less
The critical role of the class III histone deacetylase SIRT2 in stabilizing N-Myc oncoprotein. Cancer is the commonest cause of death from disease in children. Neuroblastoma is the commonest solid tumor in early childhood. This project will investigate the critical roles of SIRT2 protein in increasing the expression of N-Myc oncoprotein and consequently inducing neuroblastoma, and SIRT2 inhibitors as anticancer agents.
Identification of novel therapeutic targets for selectively eliminating cancer stem cells in paediatric leukaemia. Leukaemia is the most common form of cancer in children, and while the majority of children can be cured, those who relapse face a dire prognosis. It is widely believed that leukemic stem cells are responsible for relapse and this project will aim to unravel their underlying biology and identify new targets for therapeutic approaches to the disease.
Understanding endocrine tumorigenesis - opportunities for new diagnostics and therapies. This project will generate new knowledge significant for improving cancer diagnosis and designing new therapies for cancer patients as we embrace the personalised medicine era. Specific focus is on endocrine tumours. This research has as its aim improved survival for people diagnosed with cancer.
Unravelling early self-regulation: A longitudinal study. National data show persistent issues in Australian children's social-emotional vulnerability. Research shows we have had limited success shifting these trajectories through current education and intervention efforts. In short, we understand enough about self-regulation to establish it as a priority target in early childhood, yet not enough to meaningfully alter current trajectories. This project will develop a ‘big picture’ theory of child ....Unravelling early self-regulation: A longitudinal study. National data show persistent issues in Australian children's social-emotional vulnerability. Research shows we have had limited success shifting these trajectories through current education and intervention efforts. In short, we understand enough about self-regulation to establish it as a priority target in early childhood, yet not enough to meaningfully alter current trajectories. This project will develop a ‘big picture’ theory of children’s self-regulation abilities and change, supported by Australia’s first longitudinal study of early self-regulation, from preschool into early primary school (ages 4 to 6). This robust theory of change is expected to better position ongoing education and intervention efforts to succeed.Read moreRead less
Vesicles stabilised by compressed carbon dioxide as nanoreactors and templates for radical polymerisation. A new environmentally friendly method for synthesis of surfactant vesicles involving stabilisation using low pressure carbon dioxide will be applied to the synthesis of hollow polymeric nanoparticles and polymer of well-defined structure. The resulting polymeric structures will have applications in drug delivery and nano-engineered materials.
Engaging the forgotten public health workforce. This Fellowship project aims to provide the first in-depth, coordinated, critical public health examination and application of consumer behaviour-informed methodology to examine health promotion and complementary medicine. The project aims to build on novel analyses and critical engagement with community members, health professionals and policymakers to advance public health scholarship of health information-seeking and chronic illness prevention. ....Engaging the forgotten public health workforce. This Fellowship project aims to provide the first in-depth, coordinated, critical public health examination and application of consumer behaviour-informed methodology to examine health promotion and complementary medicine. The project aims to build on novel analyses and critical engagement with community members, health professionals and policymakers to advance public health scholarship of health information-seeking and chronic illness prevention. It seeks to identify challenges and opportunities to improve Australian health promotion initiatives; provide an evidence-base to inform coordinated implementation of the National Preventive Health Strategy; and optimise the primary care workforce to benefit health promotion for Australians.Read moreRead less
Enhanced algal biofuel production: optimising photosynthesis in Australian strains of marine algae. Algal biofuel produces a sustainable liquid fuel to help meet our future energy needs. This project will pioneer a multifaceted approach in molecular biology and photophysiology to engineer the best biofuel producers from Australian marine algae and will advance innovation in Australia's biofuel biotechnology development.
Determination of cellular mechanisms underpinning cancer cell metastasis through integrated in vivo imaging approaches. Understanding key steps that drive the spread of cancer is critical to improve current treatment strategies. Using cutting-edge imaging technology and in vivo model systems that mimic the disease, this project will pinpoint key events that are susceptible to drug intervention and identify new therapeutic targets.