High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Translating Genetic Determinants Of Glaucoma Into Better Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$9,466,000.00
Summary
Glaucoma is the leading cause of irreversible blindness worldwide. By 2020, it will affect 80 million people, and in Australia over the next decade, the overall cost of glaucoma will reach $4.3 billion per annum. This Program will use genetic advances to personalise treatment. Blindness will be prevented in individuals at highest risk, new ways to treat patients will be developed, and better outcomes for patients will result from less treatment and monitoring of low risk cases.
Translation Of Glaucoma Blindness Genes To Improve Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$856,795.00
Summary
Glaucoma is a common cause of irreversible blindness. It is currently difficult to predict which patients with the earliest signs of glaucoma will develop blinding stages of the disease. This study will investigate how genes and eye measurements can be used to predict the risk of developing severe glaucoma in people with early signs of disease. This will ensure that high risk individuals can access treatment early, while those at low risk can be spared unnecessary treatment and seen less often.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
Connecting and generalising arithmetic into powerful abstract systems: Year 2 to 5 children's cognitive development with respect to algebraic reasoning. Algebra is a fundamental area of mathematical thinking. In spite of the wealth of research at both the national and international level, algebraic thinking still persists as a barrier to secondary and tertiary mathematics. This project will develop new research integrating alegbra and arithmetic at the primary level as a key for access to higher ....Connecting and generalising arithmetic into powerful abstract systems: Year 2 to 5 children's cognitive development with respect to algebraic reasoning. Algebra is a fundamental area of mathematical thinking. In spite of the wealth of research at both the national and international level, algebraic thinking still persists as a barrier to secondary and tertiary mathematics. This project will develop new research integrating alegbra and arithmetic at the primary level as a key for access to higher levels of algebra. The investigators will engage teachers and students from 5 primary schools to construct a model of Year 2 to 5 children's cognitive development with regard to algebraic reasoning and develop instructional strategies and teaching episodes to facilitate this.Read moreRead less
Inquiry Teaching in Mathematics: Accelerating the process of change. Inquiry-based learning in mathematics immerses students in solving authentic, complex problems. As a nation, Australia spends too much time on repetitive, isolated procedural problems which inhibit creativity and higher-order thinking and contribute to the sharp decline in student interest in studying mathematics. Research has shown that teachers require support over time to become proficient in engaging students in inquiry of ....Inquiry Teaching in Mathematics: Accelerating the process of change. Inquiry-based learning in mathematics immerses students in solving authentic, complex problems. As a nation, Australia spends too much time on repetitive, isolated procedural problems which inhibit creativity and higher-order thinking and contribute to the sharp decline in student interest in studying mathematics. Research has shown that teachers require support over time to become proficient in engaging students in inquiry of real-life problems. This study expands successful longitudinal research on teachers' adoption of inquiry methods in mathematics and works to study ways to accelerate the process of developing teachers' confidence and expertise in teaching mathematics with inquiry. Read moreRead less
Mathematical Modelling in Early Education. This study is about enhancing children's and teachers' capacities to engage in basic mathematical modelling, which lays the foundation for working with complex systems. New and innovative learning experiences will provide all children with future-oriented mathematical understandings and social skills that are essential for effective participation in a knowledge-based society, but are underrepresented in current curricula. A new research approach, multil ....Mathematical Modelling in Early Education. This study is about enhancing children's and teachers' capacities to engage in basic mathematical modelling, which lays the foundation for working with complex systems. New and innovative learning experiences will provide all children with future-oriented mathematical understandings and social skills that are essential for effective participation in a knowledge-based society, but are underrepresented in current curricula. A new research approach, multilevel collaboration, will be adopted involving children, teachers, research students, and researchers in an international learning community. The outcomes will include explanatory models of children's and teachers' modelling developments, the training of new research scholars, the documentation of innovative curriculum, and advancements in teacher education.Read moreRead less
Primary classroom teacher-student interactions, cultural learning environments and their relationships with students' attitudes and understanding of science concepts. This project examines associations between teacher-student interactions and primary students' perceptions of cultural factors of learning environments with students' attitudes towards science and their understanding of science concepts. In the tradition of classroom environment research, the study will use interviews and questionna ....Primary classroom teacher-student interactions, cultural learning environments and their relationships with students' attitudes and understanding of science concepts. This project examines associations between teacher-student interactions and primary students' perceptions of cultural factors of learning environments with students' attitudes towards science and their understanding of science concepts. In the tradition of classroom environment research, the study will use interviews and questionnaires to obtain students' perceptions of their primary classrooms. In-depth studies will then be made of particular classrooms with the aim of enhancing the description of primary school science teaching. The project will lead to a systematic understanding of what is happening in primary school science and a direction for teachers to implement desirable changes in their teaching.Read moreRead less
The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These f ....The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These findings will inform the current debate about the appropriate models of teacher education and the balance of emphasis on content knowledge and pedagogical knowledge. Secondly, given a number of attempts to attract mid career professionals with high qualifications to teaching, the study will provide evidence on how these people transition to their new careers and what support is needed.Read moreRead less