Role Of The Ets-family Transcription Factor Erg In Haematopoiesis
Funder
National Health and Medical Research Council
Funding Amount
$100,621.00
Summary
Development of blood cells is controlled by specific molecules called transcription factors. Transcription factors are important in developing mature white cells, red cells and platelets from blood stem cells. We have discovered that a transcription factor, Erg, is important in control of blood stem cells and blood cell development as well as being implicated in human cancers, including acute leukaemia. This project will characterise how this molecule is involved in these specific processes.
The Role Of BMP Signalling During Chronic Demyelination And Myelin Repair
Funder
National Health and Medical Research Council
Funding Amount
$67,381.00
Summary
Multiple sclerosis (MS) is the most common neurodegenerative disease affecting young adults. It is a disease that kills myelin cells, which are important support cells for neurons and critical for neuronal function. This research investigates the role of a specific signaling pathway with respect to myelin cell production and repair with the ultimate aim of identifying regenerative therapeutics for MS.
Microvascular Complications Of Diabetes - Potential Role Of Regenerative Therapies
Funder
National Health and Medical Research Council
Funding Amount
$32,003.00
Summary
The global burden of diabetes is projected to reach more than 366 million by 2025. According to the AusDiab 2005 study, each year 0.8% of Australians develop diabetes. Diabetes is the leading cause of end-stage kidney disease in Australia. Current treatments slow damage to the kidney, but do not reverse kidney damage. We will explore the potential for adult progenitor cells (endothelial progenitor cells) to reverse damage to the kidney and restore its function.