Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100121
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Three-dimensional super-resolution nanophotonic fabrication facility. This stimulated emission depletion microscopy nanophotonic fabrication facility will be the first nanophotonic fabrication facility that is able to achieve optical resolution far beyond the diffraction limit, which will facilitate breakthroughs in cutting-edge nanotechnology research areas.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100199
Funder
Australian Research Council
Funding Amount
$367,900.00
Summary
Advanced Synthesis System for Two-Dimensional Nanomaterials. Advanced synthesis system for two-dimensional nanomaterials:
This project aims to establish the first synthesis facility in Australia for growing large-area and atomically thin two-dimensional (2-D) nanomaterials including graphene, boron nitride, metal dichalcogenides, metal oxide and nitride nanosheets. Such materials are emerging and innovative materials that possess many properties desirable for energy, electronic, biological, and ....Advanced Synthesis System for Two-Dimensional Nanomaterials. Advanced synthesis system for two-dimensional nanomaterials:
This project aims to establish the first synthesis facility in Australia for growing large-area and atomically thin two-dimensional (2-D) nanomaterials including graphene, boron nitride, metal dichalcogenides, metal oxide and nitride nanosheets. Such materials are emerging and innovative materials that possess many properties desirable for energy, electronic, biological, and environmental related applications. This facility is designed to underpin breakthrough science by providing high-quality large-sized materials to researchers for both fundamental and application research. This new synthesis capability would foster advances in the fundamental understanding of 2-D nanostructures and the development of devices with broad applications in energy conversion and storage, environmental protection, and life sciences.Read moreRead less
Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Prion-like Behaviour In Immunity: Super-sized Signalling Platforms?
Funder
National Health and Medical Research Council
Funding Amount
$611,995.00
Summary
Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.
Nonlinear near-field nanophotonics. This project aims to develop nanostructures which employ both high intrinsic nonlinearities and high indices of refraction to create nanophotonic devices. Silicon photonics promises a technological leap forward through efficient photon-photon interactions within lossless dielectric nanoparticles. Light-controlling-light devices open new ways to control light-matter interaction at the nanoscale, which form the basis for many applications from all-optical inform ....Nonlinear near-field nanophotonics. This project aims to develop nanostructures which employ both high intrinsic nonlinearities and high indices of refraction to create nanophotonic devices. Silicon photonics promises a technological leap forward through efficient photon-photon interactions within lossless dielectric nanoparticles. Light-controlling-light devices open new ways to control light-matter interaction at the nanoscale, which form the basis for many applications from all-optical information processing to biomedical sensing. The expected outcomes will provide Australia with advanced technologies of integrated optical circuits with applications in optical communication networks, bioimaging, solar cells and quantum information technologies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100592
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Fabrication strategies for nanophotonic devices. The project will develop novel strategies to engineer nanophotonic entities to control and guide light at the nanoscale. These nanostructures will open up new avenues for integrated multifunctional devices spanning sensing, light emission and quantum communications, positioning Australia at the frontier of nanoscience and quantum technologies.
Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Next generation material imaging, spectrometry and fabrication techniques. This project aims to solve a common, fundamental problem limiting the performance of mass spectrometers and high resolution electron microscopes: surface modification caused by unintended chemical reactions due to electron impact. The intended project outcomes will advance current understanding of electron restructuring of surfaces and open the door to next-generation material imaging, spectrometry and fabrication techniq ....Next generation material imaging, spectrometry and fabrication techniques. This project aims to solve a common, fundamental problem limiting the performance of mass spectrometers and high resolution electron microscopes: surface modification caused by unintended chemical reactions due to electron impact. The intended project outcomes will advance current understanding of electron restructuring of surfaces and open the door to next-generation material imaging, spectrometry and fabrication techniques. It will develop a superior detector for mass spectrometry and improve the imaging and nanofabrication capabilities of state-of-the-art electron microscopes. Read moreRead less