Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Prion-like Behaviour In Immunity: Super-sized Signalling Platforms?
Funder
National Health and Medical Research Council
Funding Amount
$611,995.00
Summary
Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.
Assembly And Transport Of Herpes Simplex Virus Within Neurones
Funder
National Health and Medical Research Council
Funding Amount
$475,500.00
Summary
Herpes simplex virus (HSV) enters the human body via the skin before entering the termini of nerve cell processes. It is transported along these processes to the body of the nerve cell. HSV lies dormant within these nerve cell bodies near the spinal cord in most people. Intermittently the virus reactivates and is transported back down the nerve cell processes to the skin where it causes blisters-ulcers or is shed without causing symptoms. The aim of this grant is to determine how HSV is transpor ....Herpes simplex virus (HSV) enters the human body via the skin before entering the termini of nerve cell processes. It is transported along these processes to the body of the nerve cell. HSV lies dormant within these nerve cell bodies near the spinal cord in most people. Intermittently the virus reactivates and is transported back down the nerve cell processes to the skin where it causes blisters-ulcers or is shed without causing symptoms. The aim of this grant is to determine how HSV is transported and assemblied within nerve cells at the molecular level. Recent discoveries have shown how virus transport in nerve cells is dependent on interactions between specific viral proteins and cellular motor proteins. Such information on viral transport and assembly mechanisms will allow development of inhibitors of these processes which may be candidates for use as antivirals for control of recurrent herpes simplex. In addition, this information will allow the virus to be exploited for use in gene therapy to introduce DNA into human nerve cells to correct genetic abnormalities.Read moreRead less
Large-scale highly dynamic wireless networks: architecture and communication strategies design. This project will develop novel techniques for the modelling, design and management of highly dynamic networks, with wireless vehicular networks for autonomous vehicles being a typical but not sole example. Social and economical benefits are expected in the areas of road traffic management and road safety, communication and environment protection.
Development of fundamental perception technology and algorithms for mining safety. The project will push the boundaries of mining safety research to deliver innovative and powerful tools to understand and control the level of risk of an operation. This knowledge will be used to develop algorithms to best assess safety issues in different scenarios, to design safety procedures and to develop operator training.
Discovery Early Career Researcher Award - Grant ID: DE150101704
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Cloud-based Massive MIMO Design for Future 5G Cellular Networks. As the radio spectrum for cellular services is quickly running out, the next generation cellular networks require some fundamental technology advances to meet the exponentially growing traffic demand. This project aims to produce a cloud-based massive multiple-input-multiple-output cellular system to achieve a substantially higher system capacity without additional spectrum. Key research issues will be addressed by developing novel ....Cloud-based Massive MIMO Design for Future 5G Cellular Networks. As the radio spectrum for cellular services is quickly running out, the next generation cellular networks require some fundamental technology advances to meet the exponentially growing traffic demand. This project aims to produce a cloud-based massive multiple-input-multiple-output cellular system to achieve a substantially higher system capacity without additional spectrum. Key research issues will be addressed by developing novel interference suppression techniques based on joint signal processing and cloud-based resource allocations. The project aims to leverage recent advances in cloud-based optimisation and utilise interference cancellation to provide fundamentally new approaches in increasing the capacity of cellular systems.Read moreRead less
Efficient signal transmission techniques for large scale antenna systems. This project aims to design efficient signal transmission techniques for large scale antenna wireless systems that can significantly improve network capacity and radio spectrum efficiency. Large scale antenna arrays deployed in cellular networks is a promising technique to accommodate the dramatically increasing data demands for next generation wireless communications. The intended outcome of the project will bring revolut ....Efficient signal transmission techniques for large scale antenna systems. This project aims to design efficient signal transmission techniques for large scale antenna wireless systems that can significantly improve network capacity and radio spectrum efficiency. Large scale antenna arrays deployed in cellular networks is a promising technique to accommodate the dramatically increasing data demands for next generation wireless communications. The intended outcome of the project will bring revolutionary change in mobile wireless communications and benefit billions of people in the world. It will significantly lift productivity and economic growth in Australia.Read moreRead less
Inter-cell interference modelling and control in future cellular systems. Small cells and frequency reuse are the key concepts in increasing the capacity of wireless cellular networks. However, the deployment of dense cells increases interference and limits the network capacity. This project will deliver novel interference control methods, capable of improving the spectral and energy efficiency in cellular networks.
Overcoming the wireless throughput bottleneck: new heterogeneous architectures and algorithms for high data rate mobile broadband. Mobile communication networks are facing a rapid increase in broadband data with traffic forecast to increase by 18 times over the next five years. This project will create novel techniques for the design of a new wireless multi-layered network architecture that will scale to meet this demand whilst minimising the energy footprint of the network.
Overseeing the internet: new paradigms of network measurement. Like the electricity network, the internet is a core infrastructure, and so must be reliable and efficient. A gap in bandwidth supply is like a blackout in terms of lost business and productivity. This project will provide the measurement breakthroughs to ensure that network behaviour can be accurately and comprehensively monitored.