The role of human single-stranded binding protein (hSSB1) in DNA damage repair and tumorogenesis. Cancer is a leading cause of disease related death world wide, accounting for over 13% of all deaths in 2007. Approximately 38,000 people died in Australia from cancer in 2005. Cancer results from a single cell losing a vital part of its genetic information, this results in the cell losing its normal programming and initiates a process of rapid growth and multiplication. This research project aims t ....The role of human single-stranded binding protein (hSSB1) in DNA damage repair and tumorogenesis. Cancer is a leading cause of disease related death world wide, accounting for over 13% of all deaths in 2007. Approximately 38,000 people died in Australia from cancer in 2005. Cancer results from a single cell losing a vital part of its genetic information, this results in the cell losing its normal programming and initiates a process of rapid growth and multiplication. This research project aims to look at the mechanisms that exist to prevent this initial loss of genetic material within an individual cell. It further aims to translate theses discoveries into the clinic, providing new tools for diagnosis and prognosis of specific cancers and to establish links with major pharmaceutical companies to develop novel anticancer therapies.Read moreRead less
Enabling Automatic Graph Learning Pipelines with Limited Human Knowledge. This project aims to develop an automatic graph learning system for complex graph data analysis. Machine learning for graph data commonly requires significant human knowledge from both domain professionals as well as algorithm experts, rendering existing systems ineffective and unexplainable. This project expects to design novel graph learning techniques which automatically infer graph relations, learn graph models, adapts ....Enabling Automatic Graph Learning Pipelines with Limited Human Knowledge. This project aims to develop an automatic graph learning system for complex graph data analysis. Machine learning for graph data commonly requires significant human knowledge from both domain professionals as well as algorithm experts, rendering existing systems ineffective and unexplainable. This project expects to design novel graph learning techniques which automatically infer graph relations, learn graph models, adapts existing knowledge to new domains, and provide explanations to the graph learning system. The research results should provide benefit to governments and businesses in many critical applications, such as bioassay activity prediction, credit assessment, and drug discovery and vaccine development in response to the pandemic.Read moreRead less
Multi-modal virtual microscopy for quantitative diagnostic pathology. This project will contribute to the next generation of virtual microscopy systems that provide innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of diagnostic pathology. These tools will especially contribute to the screening and diagnosis of cervical, lung and bladder cancer.
Molecular basis of glutamate receptor trafficking in neuronal plasticity . Neurons communicate via synapses, where chemicals (such as glutamate) are released to transmit neuronal signals. This proposal is aimed at understanding the molecular mechanisms of neuronal communication and adaptive plasticity, which are essential for normal brain function. The proposed research will combine biophysical, biochemical, molecular and cell biological assays to elucidate how the trafficking of glutamate recep ....Molecular basis of glutamate receptor trafficking in neuronal plasticity . Neurons communicate via synapses, where chemicals (such as glutamate) are released to transmit neuronal signals. This proposal is aimed at understanding the molecular mechanisms of neuronal communication and adaptive plasticity, which are essential for normal brain function. The proposed research will combine biophysical, biochemical, molecular and cell biological assays to elucidate how the trafficking of glutamate receptors is regulated in neurons during plasticity and learning. The outcomes will enhance our understanding of how neural plasticity is generated and maintained, knowledge that is critical for our understanding of the cellular correlates of information, sensory and motor processing, as well as learning, memory and cognition.Read moreRead less
Interrogating a novel protein scaffold that coordinates signal transduction and molecular motor function. The inside of a cell is an extremely crowded environment and the precise location of each component is carefully controlled. This project will unravel the protein machinery involved in transporting cargos in cells as they divide and identify new protein targets for the development of next generation anti-cancer drugs.
High throughput engineering of genetically encodable fluorescent sensors of intracellular signalling networks. Understanding of biochemical processes in living organisms is central to biological research and drug discovery. At present, the field suffers from a chronic paucity of adequate observation methods. The proposed project represents an interdisciplinary effort to create approaches for real-time monitoring of complex cellular chemistries. This work will deliver novel technologies for use i ....High throughput engineering of genetically encodable fluorescent sensors of intracellular signalling networks. Understanding of biochemical processes in living organisms is central to biological research and drug discovery. At present, the field suffers from a chronic paucity of adequate observation methods. The proposed project represents an interdisciplinary effort to create approaches for real-time monitoring of complex cellular chemistries. This work will deliver novel technologies for use in diagnostics and drug development. It will provide vital information on the changes in cellular processes induced by malignant transformation, viral infection and aging. This work will generate both health and economic benefits for the community and have a positive impact on the international visibility of Australian biomedical research.Read moreRead less
Model checking Multi-Agent System and its applications. This research project directly addresses two of the Australian Government's four National Research Priorities: National Research Priorities 3 and 4. It will develop an enabling technology that is applicable to the development of safety-intensive and highly dependable software systems like medical equipment and airport controlling systems. The security protocol analysis technologies developed by this project can be useful for providing impro ....Model checking Multi-Agent System and its applications. This research project directly addresses two of the Australian Government's four National Research Priorities: National Research Priorities 3 and 4. It will develop an enabling technology that is applicable to the development of safety-intensive and highly dependable software systems like medical equipment and airport controlling systems. The security protocol analysis technologies developed by this project can be useful for providing improved ways of military operation flows, and for making Australian security communication systems more dependable.Read moreRead less
Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowle ....Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowledge of previously intractable developmental processes, training of future scientists and development of international collaborations. This should provide enhanced imaging capacity, a higher quality scientific workforce and position Australia at the forefront of developmental biology.
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The role of strong duality in computer vision. This project aims to undertake research in the fields of computer vision and optimization that will have a significant impact on the design of numerical algorithms for solving a wide range of problems in Computer Vision, Virtual Reality and Robotic Navigation. This project will advance understanding of a broad class of problems related to how computers interpret images. An expected outcome is the generation of novel mathematical theory and numerical ....The role of strong duality in computer vision. This project aims to undertake research in the fields of computer vision and optimization that will have a significant impact on the design of numerical algorithms for solving a wide range of problems in Computer Vision, Virtual Reality and Robotic Navigation. This project will advance understanding of a broad class of problems related to how computers interpret images. An expected outcome is the generation of novel mathematical theory and numerical algorithms capable of fundamentally changing the way problems relevant to a wide range of vision-related applications are solved. This should offer Australia a strong competitive advantage as a leader in scientific innovation in the areas of Computer Vision, Virtual Reality and Robotics and Autonomous Systems.Read moreRead less
A pictorial communication framework for inclusion. A picture can tell a thousand words; many people with an intellectual disability can only communicate with pictures and are otherwise isolated. This project will research how computers can understand and facilitate a rich pictorial communication between people and person to machine, thereby supporting inclusion. This will be achieved by inclusively co-designing with people with ID and members of the community: a) an audio-visual accessible searc ....A pictorial communication framework for inclusion. A picture can tell a thousand words; many people with an intellectual disability can only communicate with pictures and are otherwise isolated. This project will research how computers can understand and facilitate a rich pictorial communication between people and person to machine, thereby supporting inclusion. This will be achieved by inclusively co-designing with people with ID and members of the community: a) an audio-visual accessible search tool, b) a pictorial communication device, and c) a visual inclusive social network. These applications will inform future innovations for everyone, and allow citizens with ID to access online information, participate in community activities and be included in the workplace.Read moreRead less