Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of profi ....Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of proficiency testing and continuing education vital for a vibrant, well regulated discipline. In addition, the project will contribute to our knowledge of the pathology assessed in the screening and diagnosis of cancers such as cervical, lung and bladder cancers.Read moreRead less
Improved detection and characterisation of breast cancer using magnetic resonance imaging, and novel image analysis and pattern recognition techniques. Breast cancer is a leading cause of death in Australian women. With no clear cause, one mainstay of management has been early detection. Newer medical imaging technologies such as magnetic resonance imaging require complex analysis to achieve their full benefit. Should the computationally demanding analyses of these images provide more sensitive ....Improved detection and characterisation of breast cancer using magnetic resonance imaging, and novel image analysis and pattern recognition techniques. Breast cancer is a leading cause of death in Australian women. With no clear cause, one mainstay of management has been early detection. Newer medical imaging technologies such as magnetic resonance imaging require complex analysis to achieve their full benefit. Should the computationally demanding analyses of these images provide more sensitive and specific detection of early cancers, the potential reductions in morbidity and mortality from breast cancer will be of immense value. Successful implementation of the proposed project will further enhance Australia's position as a world leader in biomedical research and application of computational technologies to health problems.Read moreRead less
Special Research Initiatives - Grant ID: SR0567196
Funder
Australian Research Council
Funding Amount
$55,000.00
Summary
Improved early detection of breast cancer enabled by grid-computing and advanced modelling and visualisation of MR images. This project will investigate the utility of grid computing in the detection of breast cancer from magnetic resonance (MR) images. The large quantity of data acquired using MR imaging is difficult for clinicians to review and the cost of missed or incorrect detection is high. To provide rapid visualisation and assessment of the acquired data, grid computing will be used in c ....Improved early detection of breast cancer enabled by grid-computing and advanced modelling and visualisation of MR images. This project will investigate the utility of grid computing in the detection of breast cancer from magnetic resonance (MR) images. The large quantity of data acquired using MR imaging is difficult for clinicians to review and the cost of missed or incorrect detection is high. To provide rapid visualisation and assessment of the acquired data, grid computing will be used in conjunction with interactive visualisation with haptic feedback. Grid computing experience and haptic device expertise will be achieved via Swedish collaborators. The successful outcome of this project will be software for the production of 3D colour-coded breast images in which suspicious regions are highlighted and can be physically interrogated using the haptic device.Read moreRead less
Intelligent Image Processing Techniques for Novel Biomarker Discovery. This project will make an impact on Australia's international research profile by seeking a solution to a worldwide challenging problem in biomarker discovery for the detection of diseases at an early stage which requires the incorporation of the skills and knowledge from biology, medicine, engineering, computer science, and information technology. The successful outcomes of this research will make an impact on Australia's e ....Intelligent Image Processing Techniques for Novel Biomarker Discovery. This project will make an impact on Australia's international research profile by seeking a solution to a worldwide challenging problem in biomarker discovery for the detection of diseases at an early stage which requires the incorporation of the skills and knowledge from biology, medicine, engineering, computer science, and information technology. The successful outcomes of this research will make an impact on Australia's engagement in using advanced image analysis and intelligent methods for the emerging research and development of targeted drug discovery. Read moreRead less
An Automated Bioimaging System for High-Content Cell-Cycle Screening. 1) Providing a better understanding of the biological complexities
that will advance knowledge in life science research and facilitate the development of new anti-cancer drugs.
2) Supporting Australian academic institutions in a challenging field of innovative research through international, interdisciplinary collaborations, and publications in journals of high quality scientific research.
3) Providing research training ....An Automated Bioimaging System for High-Content Cell-Cycle Screening. 1) Providing a better understanding of the biological complexities
that will advance knowledge in life science research and facilitate the development of new anti-cancer drugs.
2) Supporting Australian academic institutions in a challenging field of innovative research through international, interdisciplinary collaborations, and publications in journals of high quality scientific research.
3) Providing research training in a research venture that requires expertise and collaboration in the disciplines of biology, engineering, computer science, and mathematics.
4) Bringing economic and social benefits for Australia by enhancing important industries and existing technologies in medicine, and biotechnology.
Read moreRead less
Generalised Linear Mixed Models: Theory, Methods and New Areas of Application. This project will aid the analysis of complex data sets throughout Australia. The ensuing methodology and software products will be applicable to data arising from longitudinal and geo-referenced public health and biomedical studies being conducted in Australia. It will also aid analysis of complex survey data from the Australian Bureau of Statistics and other agencies. Part of this project is geared towards smart inf ....Generalised Linear Mixed Models: Theory, Methods and New Areas of Application. This project will aid the analysis of complex data sets throughout Australia. The ensuing methodology and software products will be applicable to data arising from longitudinal and geo-referenced public health and biomedical studies being conducted in Australia. It will also aid analysis of complex survey data from the Australian Bureau of Statistics and other agencies. Part of this project is geared towards smart information use in Australian industries and will help foster collaboration between mathematical scientists and members of the Australian business sector. Cancer research in Australia will also benefit from this project.Read moreRead less
Differential Isotope Proteome Mapping of Transforming Growth Factor Beta Cell Signalling. Our research will capitalise on Australia's expertise and prior infrastructure investments in frontier, proteomic technologies to elucidate novel intracellular signalling pathways that contribute to the development of cancer. New approaches will be developed using isotopes to provide sensitive and accurate measurements of changes in protein expression levels. This technology will allow us to define complex ....Differential Isotope Proteome Mapping of Transforming Growth Factor Beta Cell Signalling. Our research will capitalise on Australia's expertise and prior infrastructure investments in frontier, proteomic technologies to elucidate novel intracellular signalling pathways that contribute to the development of cancer. New approaches will be developed using isotopes to provide sensitive and accurate measurements of changes in protein expression levels. This technology will allow us to define complex intracellular signalling networks. This is an important step towards identifying new drug targets that are responsible for tumour growth. Australian science will benefit from the training of new scientists in modern, post-genome technologies where there is currently a world shortage of experienced personnel.Read moreRead less
The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with res ....The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561173
Funder
Australian Research Council
Funding Amount
$207,189.00
Summary
High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomics Workstation. As research in the biological sciences moves into post-genomics era, so attention has focused on the development of technologies capable of characterizing the molecular complexity inherent in the proteome. Recent technical innovations in this field have resulted in the advancement of mass spectrometers that are capable of exemplifying unknown proteins with great efficiency. These new technologies are ....High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomics Workstation. As research in the biological sciences moves into post-genomics era, so attention has focused on the development of technologies capable of characterizing the molecular complexity inherent in the proteome. Recent technical innovations in this field have resulted in the advancement of mass spectrometers that are capable of exemplifying unknown proteins with great efficiency. These new technologies are central to any institution committed to the development of a competitive research nexus in biological sciences. The purpose of this application is to upgrade the mass spectrometry facility at the University of Newcastle such that it is able to provide cutting edge support to the extensive scientific community within the Hunter region.Read moreRead less
Synchrotrons, wavelet analysis and novel imaging techniques - applying physics tools to the war against breast cancer. Breast cancer leads to the second highest number of person-years of life lost due to cancer in Australia, with little known about its transport around the body. Current screening methods for breast cancer are neither 100% sensitive or specific and are heavily dependent upon expert training. This project will contribute by yielding valuable information on the transport of breast ....Synchrotrons, wavelet analysis and novel imaging techniques - applying physics tools to the war against breast cancer. Breast cancer leads to the second highest number of person-years of life lost due to cancer in Australia, with little known about its transport around the body. Current screening methods for breast cancer are neither 100% sensitive or specific and are heavily dependent upon expert training. This project will contribute by yielding valuable information on the transport of breast cancer and contribute to the development of an automated diagnostic method, with the possibility of its application to other diseases. The project will also involve members of the regional community, train regional scientists and provide synchrotron experience for Australian scientists in time for Australia's first synchrotron.Read moreRead less