Directed Molecular Evolution Of G Protein-coupled Receptors For Stable And Functional Expression In Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$383,479.00
Summary
Approximately half of all prescription drugs on the market act on G protein coupled receptors (GPCRs). The mechanisms underlying GPCR function are mainly unknown due to a lack of structural information. No solved structures exist for any of the estimated 800 human GPCRs, making it difficult to design new drugs. By applying advanced protein engineering techniques I aim to produce human GPCRs in bacteria to ultimately acquire structural information, which will enable novel drug development.
Assembly And Function Of Two Interacting Oncogenic Scaffolds
Funder
National Health and Medical Research Council
Funding Amount
$705,585.00
Summary
Aberrant signaling by the protein kinase superfamily is a known driving force for many cancers and inflammatory diseases. Recently, a subset of kinase-like proteins, termed pseudokinases, have emerged as crucial regulators of kinase signalling pathways. This proposal focuses on elucidating the scaffolding function and assembly of two pseudokinases, termed SgK223 and SgK269, which display oncogenic properties and aims to understand how their signalling abilities are subverted in a disease state.
Design And Engineering Of Adnectins For Diagnosis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$803,152.00
Summary
This project aims to engineer a naturally-occurring human protein, called an adnectin, to produce molecules that are able to bind specific targets in the human body, and as such may be used in the diagnosis and therapy of a range of diseases.
Alzheimer’s disease (AD), is the most common form of dementia, accounting for between 50-70% of all cases. There is general agreement that current treatments for AD/dementia are inadequate so new treatment strategies are desperately needed. I am addressing these challenges by developing new technologies to generate next generation treatments for AD.
Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitab ....Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitable for use in compact electrical devices requiring high current density. This project will add to the techniques used for the analysis of carbon coatings being developed in Australia. Read moreRead less
Single atom defined nanostructures: atom-electronics beyond the miniaturization limit. The emerging era of atom-electronics promises to revolutionise microelectronics in the 21st century by going beyond the conventional miniaturization limit of microelectronics. Emerging atom level fabrication and control techniques offer the promise of building devices whose fundamental components are built atom-by-atom and function under completely new rules. This Discovery Project will apply critical new theo ....Single atom defined nanostructures: atom-electronics beyond the miniaturization limit. The emerging era of atom-electronics promises to revolutionise microelectronics in the 21st century by going beyond the conventional miniaturization limit of microelectronics. Emerging atom level fabrication and control techniques offer the promise of building devices whose fundamental components are built atom-by-atom and function under completely new rules. This Discovery Project will apply critical new theoretical tools, in partnership with leading experimental groups, to enable the exploration of this technology and the creation of new and innovative applications which will have far reaching implications in all areas of society and significant national benefit.Read moreRead less
Braiding Dynamics of Majorana Modes. The project aims to investigate Majorana modes, exotic quantum particles which can be found in the new material class of Topological Superconductivity. In particular, they can be utilised to construct fault-tolerant quantum bits. Quantum logic gates are enabled by moving these Majorana modes around each other, i.e., by braiding them, leading to an error-free quantum performance. This project will deliver cutting-edge simulations to analyse the braiding proces ....Braiding Dynamics of Majorana Modes. The project aims to investigate Majorana modes, exotic quantum particles which can be found in the new material class of Topological Superconductivity. In particular, they can be utilised to construct fault-tolerant quantum bits. Quantum logic gates are enabled by moving these Majorana modes around each other, i.e., by braiding them, leading to an error-free quantum performance. This project will deliver cutting-edge simulations to analyse the braiding process in condensed matter systems and benchmark how these fault-tolerant quantum bits operate under real-world conditions. By providing the theory for advanced structures and devices, this project will inform experiments and pave the way for future technology based on topological phenomena.Read moreRead less
Crosstalk Between The Repressive Histone Methyltransferases PRC2 And G9A: Structure-function Investigation To Open New Therapeutic Opportunities
Funder
National Health and Medical Research Council
Funding Amount
$595,205.00
Summary
The gene expression programs need to be precisely regulated and the misregulation of these programs can cause a broad range of human diseases. My research will focus on two protein complexes, which heavily contribute to the regulation of gene expression. My study will open a new path for developing new therapeutic strategies.
Imaging surface topography using Lloyd's Mirror in photo-emission electron microscopy. The wide-ranging and innovative nature of the proposal will significantly raise Australia's international profile in condensed matter physics through high impact publications and invited presentations at major international conferences. Researchers will be trained in cutting-edge electron microscopy and synchrotron science. A spin-off company will be formed to commercialise software for reconstructing surface ....Imaging surface topography using Lloyd's Mirror in photo-emission electron microscopy. The wide-ranging and innovative nature of the proposal will significantly raise Australia's international profile in condensed matter physics through high impact publications and invited presentations at major international conferences. Researchers will be trained in cutting-edge electron microscopy and synchrotron science. A spin-off company will be formed to commercialise software for reconstructing surface topography and generating movies of dynamic events. The development of new synchrotron based electron microscopy techniques will establish the expertise for the future creation of a dedicated nanotechnology beamline equipped with photo-emission electron microscopy which will have far reaching national benefit in the physical sciences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347797
Funder
Australian Research Council
Funding Amount
$263,000.00
Summary
A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also b ....A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also be used for high-resolution texture analysis and surface reflectivity measurements on numerous types of materials. Thus chemists, geologists, and materials scientists with interests outside of the semiconductor growth community will gain substantial benefit from this instrument for the investigation of materials of technological and economic importance.Read moreRead less