Murray Basin: A unique archive of late Neogene global change. Salinization, soil erosion, groundwater depletion and surface water degradation are but a few of the inter-related environmental problems facing the Murray-Darling Basin. These problems require an understanding of the way in which shallow groundwater, salts and surface water interact with near-surface sediments. This project is aimed at a better understanding the nature of those near-surface sediments in the Murray Basin and how th ....Murray Basin: A unique archive of late Neogene global change. Salinization, soil erosion, groundwater depletion and surface water degradation are but a few of the inter-related environmental problems facing the Murray-Darling Basin. These problems require an understanding of the way in which shallow groundwater, salts and surface water interact with near-surface sediments. This project is aimed at a better understanding the nature of those near-surface sediments in the Murray Basin and how they were formed. If we can understand how the basin came to be the way it is (in the modern setting), we may better understand the way it might behave when subject to man-made changes like increased groundwater usage, etc.Read moreRead less
Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead ....Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead to a better understanding of the geological record of greenhouse-icehouse change. Knowledge of the nature of this change in the past is critical to predicting how our climate is going to behave in the future.Read moreRead less
Seismic velocity problems associated with Cretaceous-Tertiary carbonate sediments that overlie oil and gas fields of the North West Shelf. The major aim of this collaborative study between Partner Oil Companies and The University of Melbourne is to understand seismic velocity problems associated with tropical carbonate sediments on Australias? North West Shelf. These problems can hinder the hydrocarbon exploration efforts below these carbonates. The project is a multi faceted study and will invo ....Seismic velocity problems associated with Cretaceous-Tertiary carbonate sediments that overlie oil and gas fields of the North West Shelf. The major aim of this collaborative study between Partner Oil Companies and The University of Melbourne is to understand seismic velocity problems associated with tropical carbonate sediments on Australias? North West Shelf. These problems can hinder the hydrocarbon exploration efforts below these carbonates. The project is a multi faceted study and will involve integration of seismic stratigraphy with sedimentological, micropaleontological, and geophysical data. The methods outlined below would underpin any seismic depth migration applications, thereby assisting with the delineation of new gas and oil fields, and help with the estimation of reserves in existing fields.
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Oxygenation of the oceans and the origin of animals. This research project will investigate newly discovered ancient reefs and fossils from the Flinders Ranges that may represent the oldest known animals on Earth. Results from the project will help understand the early evolution of animal life on Earth and will contribute to a greater appreciation of Australia's geological heritage.
The climate evolution of high latitude 140 to 90 million year old hydrocarbon prospective strata of Southeast Australia. Melbourne University and the Royal Botanic Gardens will collaborate with three companies to investigate climate variability in a 140 to 90 million year old greenhouse record in southeast Australia. Spore, pollen & algal studies integrated with wood & plant analyses and zircon dating will improve age estimates of hydrocarbon reservoirs in Gippsland where Lakes Oil and Nexus E ....The climate evolution of high latitude 140 to 90 million year old hydrocarbon prospective strata of Southeast Australia. Melbourne University and the Royal Botanic Gardens will collaborate with three companies to investigate climate variability in a 140 to 90 million year old greenhouse record in southeast Australia. Spore, pollen & algal studies integrated with wood & plant analyses and zircon dating will improve age estimates of hydrocarbon reservoirs in Gippsland where Lakes Oil and Nexus Energy are exploring in one of Australia's premier oil & gas producing regions. This work will lead to a better understanding of climate change in long-term greenhouse conditions. Knowledge of this in the past is critical to prediction of climate change into the futureRead moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102245
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Comparison of early mesozoic sedimentary provenances of both sides of the YarlungTsangpo suture zone and the evolution of the neotethys. This project aims to develop a new, more geologically-consistent evolution of the Neotethys and test the affinity of southern Lhasa terrane with Australian terranes. The work will provide new constraints on the early evolution of the Himalayan-Tibetan continental collision.
Directed Molecular Evolution Of G Protein-coupled Receptors For Stable And Functional Expression In Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$383,479.00
Summary
Approximately half of all prescription drugs on the market act on G protein coupled receptors (GPCRs). The mechanisms underlying GPCR function are mainly unknown due to a lack of structural information. No solved structures exist for any of the estimated 800 human GPCRs, making it difficult to design new drugs. By applying advanced protein engineering techniques I aim to produce human GPCRs in bacteria to ultimately acquire structural information, which will enable novel drug development.
Identifying Key Players In The Spread Of Antimicrobial Resistance
Funder
National Health and Medical Research Council
Funding Amount
$817,448.00
Summary
Antibiotic drugs are essential to treat bacterial infections. However some bacteria have genes that allow them to resist certain drugs, which can be transferred among bacteria to create 'superbugs' that can resist nearly all the drugs we have. This project investigates the transfer of drug resistance genes between Gram negative bacteria (common agents of food poisoning, hospital infection, UTI, etc) and aims to identify the bacteria and genes most important in the spread of superbugs in Australi ....Antibiotic drugs are essential to treat bacterial infections. However some bacteria have genes that allow them to resist certain drugs, which can be transferred among bacteria to create 'superbugs' that can resist nearly all the drugs we have. This project investigates the transfer of drug resistance genes between Gram negative bacteria (common agents of food poisoning, hospital infection, UTI, etc) and aims to identify the bacteria and genes most important in the spread of superbugs in Australia.Read moreRead less
Assembly And Function Of Two Interacting Oncogenic Scaffolds
Funder
National Health and Medical Research Council
Funding Amount
$705,585.00
Summary
Aberrant signaling by the protein kinase superfamily is a known driving force for many cancers and inflammatory diseases. Recently, a subset of kinase-like proteins, termed pseudokinases, have emerged as crucial regulators of kinase signalling pathways. This proposal focuses on elucidating the scaffolding function and assembly of two pseudokinases, termed SgK223 and SgK269, which display oncogenic properties and aims to understand how their signalling abilities are subverted in a disease state.