Large-scale Data To Understand Person-centred Outcomes In Cancer Survivors
Funder
National Health and Medical Research Council
Funding Amount
$1,163,471.00
Summary
Although the majority of people with cancer in Australia now survive long-term, little is known about long-term “person-centred outcomes” for cancer survivors - including mental health, disability, pain and quality of life. This project will use data from >70,000 cancer survivors and >190,000 people without cancer from the general population to generate new knowledge on person-centred outcomes, for different cancer types and over time, to inform and improve health and healthcare.
Genetic And Environmental Risk Factors For Colorectal Cancer: Anatomic Site Specificity
Funder
National Health and Medical Research Council
Funding Amount
$560,000.00
Summary
Cancer of the large bowel (colorectal cancer) is the second most common cancer in Australians and is becoming more common. Despite this, there is still much uncertainty about what causes some people to develop this cancer. We believe that some of this uncertainty arises because there are actually different causes of cancer for different sections of the colon and rectum. This study aims to collect information from 1000 people with colorectal cancer and 1000 people without colorectal cancer, and c ....Cancer of the large bowel (colorectal cancer) is the second most common cancer in Australians and is becoming more common. Despite this, there is still much uncertainty about what causes some people to develop this cancer. We believe that some of this uncertainty arises because there are actually different causes of cancer for different sections of the colon and rectum. This study aims to collect information from 1000 people with colorectal cancer and 1000 people without colorectal cancer, and compare various factors such as their genetic makeup, diet, AND lifestyle. We expect to find that some factors are more common in people with cancer in the upper parts of the bowel, while other factors are more common in people with cancer in the lower parts of the bowel. This kind of information can be used to design programs to prevent colorectal cancer. For example, we might advise people to exercise more or eat more fish in order to decrease their chances of developing this cancer.Read moreRead less
Novel Genetic And Environmental Modifiers Of The Risk Of Iron Overload-related Disease In HFE-associated Hereditary Haemochromatosis In Cohort Of Middle-aged Australians
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
People who carry mutations in the HFE gene are pre-disposed to body iron overload but not all of them developed subsequent disease. According to the investigators of the “HealthIron” study in Melbourne, only 28% of men and 1% of women with faulty HFE genes go on to develop disease. This study has recruited more than 1,000 people from the community, and will determine which environmental and genetic risk factors stop people with iron overload from getting symptoms of disease.
An Individual-level Study Of Suicide Method Substitution Over Time
Funder
National Health and Medical Research Council
Funding Amount
$218,122.00
Summary
This study will explore patterns of suicide methods _ e.g., whether people who attempt suicide by hanging make subsequent attempts in the following month, and, if so, whether they use the same or different methods. It will track anonymised patients who have been hospitalised for a suicide attempt in 3 Australian states to determine the extent, method and outcome of any subsequent attempts. The study will inform questions about ïbest betsÍ in terms of restricting access to means of suicide.
Novel Molecular Markers Of Lung Cancer Risk And Survival
Funder
National Health and Medical Research Council
Funding Amount
$824,765.00
Summary
Lung cancer remains the most lethal cancer worldwide, yet little is known of the risk factors beyond that of tobacco smoking and certain occupational exposures. We have assembled a large international consortium comprising 24 cohort studies and over 10,000 to validate associations between B-vitamins and lung cancer risk particularly in never and former smokers. We propose to expand this study and use the Melbourne Collaborative Cohort Study and the rest of the consortium to identify novel biomar ....Lung cancer remains the most lethal cancer worldwide, yet little is known of the risk factors beyond that of tobacco smoking and certain occupational exposures. We have assembled a large international consortium comprising 24 cohort studies and over 10,000 to validate associations between B-vitamins and lung cancer risk particularly in never and former smokers. We propose to expand this study and use the Melbourne Collaborative Cohort Study and the rest of the consortium to identify novel biomarkers of risk and survival.Read moreRead less
Genetic Epidemiology Of Endometrial Cancer: Towards Understanding Aetiology And Improving Risk Prediction.
Funder
National Health and Medical Research Council
Funding Amount
$353,573.00
Summary
Studies investigating thousands of genetic markers have revolutionised our understanding of genes involved in cancer, and shown that a single gene can be associated with multiple cancers. We will conduct the largest ever study to find new genes for endometrial cancer, the most common gynaecological cancer. Our unique approach will examine >11million markers across the genome, some specifically in regions known to be important for other cancers. Findings will be used for risk prediction models ....Studies investigating thousands of genetic markers have revolutionised our understanding of genes involved in cancer, and shown that a single gene can be associated with multiple cancers. We will conduct the largest ever study to find new genes for endometrial cancer, the most common gynaecological cancer. Our unique approach will examine >11million markers across the genome, some specifically in regions known to be important for other cancers. Findings will be used for risk prediction models.Read moreRead less
Clinical, Environmental And Genetic Factors And The Risk Of Oesophageal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$145,685.00
Summary
Oesophageal cancer is a rapidly fatal disease which is becoming more common in Australia, the United States and other industrialised nations. This study will examine the mechanisms leading to the development of oesophageal cancer and aims to measure the effects of genes and environment on the burden of cancer. Ultimately, this research will help target persons at highest risk so that screening, prevention and surveillance efforts can be directed more effectively.
The structure and dynamics of social contact for human disease transmission models. The methodological advances of this project will enable new insights in important social research. They will not only add significantly to national capacity in the modelling of complex social systems but they will also yield practical scientific outcomes in a significant policy domain in Australia and overseas. In Australia, response to diseases such as HIV, HCV and TB need new approaches, and the threat of pan ....The structure and dynamics of social contact for human disease transmission models. The methodological advances of this project will enable new insights in important social research. They will not only add significantly to national capacity in the modelling of complex social systems but they will also yield practical scientific outcomes in a significant policy domain in Australia and overseas. In Australia, response to diseases such as HIV, HCV and TB need new approaches, and the threat of pandemic influenza is significant. Read moreRead less
POPULATION-LEVEL RELEVANCE OF RISK FACTORS FOR CANCER
Funder
National Health and Medical Research Council
Funding Amount
$319,692.00
Summary
This research will provide novel up-to-date evidence-based information on the population-level relevance of lifestyle-related risk factors for cancer in Australia, by applying an advanced disease burden measure to established Australian cohort studies. This knowledge on the national cancer burden is essential for targeting cancer interventions for those at highest risk and evaluating their effectiveness.