A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
New Bayesian methodology for understanding complex systems using hidden Markov models and expert opinion, environmental, robotics and genomics applications. This project aims to merge four areas of intense international interest in describing complex systems: hidden Markov models and mixtures, semi-parametric and nonparametric approaches, true combination of expert opinion with data, and new Bayesian computational methods based on perfect sampling and particle sampling. The project will signific ....New Bayesian methodology for understanding complex systems using hidden Markov models and expert opinion, environmental, robotics and genomics applications. This project aims to merge four areas of intense international interest in describing complex systems: hidden Markov models and mixtures, semi-parametric and nonparametric approaches, true combination of expert opinion with data, and new Bayesian computational methods based on perfect sampling and particle sampling. The project will significantly contribute to statistical methodology and its ability to inform about real-world problems. A strong focus on applications to genomics, robotics and environmental modelling will bring immediate research and monetary benefit for industry. Expected outcomes include enhanced cross-disciplinary and international linkages, publications, industry-funded projects and highly trained graduates.Read moreRead less
Volatile Organic Compound removal from indoor air environments by an integrated photocatalytic/filtration system. This project promotes the development of technology for providing improved air quality in indoor environments. Mentoring by internationally renowned experts of young Australian researchers on this issue of high importance will be undertaken by the Chief and Partner Investigators. Success from this project will place Australia as a leader in the global community for developing technol ....Volatile Organic Compound removal from indoor air environments by an integrated photocatalytic/filtration system. This project promotes the development of technology for providing improved air quality in indoor environments. Mentoring by internationally renowned experts of young Australian researchers on this issue of high importance will be undertaken by the Chief and Partner Investigators. Success from this project will place Australia as a leader in the global community for developing technology in air pollution quality control.Read moreRead less
Adaptive ecotyping of the toxic cyanobacterium Cylindrospermopsis raciborskii to predict its invasive capacity. We change the world while other organisms adapt to these new conditions. Cyanobacteria (blue green algae) increasingly dominate water bodies that were previously free of these harmful blooms. To minimise the spread of these algae, this project will study the genetic basis that determines how rapidly they can evolve and adapt to a changing planet.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775548
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Advanced characterisation facilities for functional nanostructured materials. A critical factor that enhances frontier research is a set of advanced core research experimental facilities for material characterisation purposes. The proposed equipment aims to: (1) provide research facilities for advanced nanomaterial research; (2) improve national competitiveness and growth in a knowledge-based economy; and (3) foster local talented researchers in order to meet the strategic needs of the nation fo ....Advanced characterisation facilities for functional nanostructured materials. A critical factor that enhances frontier research is a set of advanced core research experimental facilities for material characterisation purposes. The proposed equipment aims to: (1) provide research facilities for advanced nanomaterial research; (2) improve national competitiveness and growth in a knowledge-based economy; and (3) foster local talented researchers in order to meet the strategic needs of the nation for a sustainable environment. These activities will revitalise Australia's leading role in creating new technologies with particular relevance to using advanced nanostructures for the production of clean air and water, and sustainable energy alternatives.Read moreRead less
CKD-FIX: A Randomised, Controlled Trial Of Allopurinol In The Slowing Of Kidney Disease Progression
Funder
National Health and Medical Research Council
Funding Amount
$1,917,147.00
Summary
Chronic kidney disease (CKD) is a major public health problem affecting over 1.5 million Australians and is associated with increased risk of death, heart disease and progression to end-stage kidney disease (ESKD). Current treatments to slow progression to ESKD are limited. The CKD-FIX trial aims to find out whether treatment with allopurinol, a commonly used drug for gout prevention, safely and effectively slows CKD progression. This could lead to significant health and economic benefits.
Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive pla ....Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive plant-soil-based biofilters for cost-effective removal of nitrogen from a range of polluted urban water sources. The project will open a potential for a new technological advancements in urban water management, while simultaneously providing benefits to the environment and community through greening and waterway protection.Read moreRead less
Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, ....Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, unprecedented in scope and resolution. Outcomes include an open access database to quantify and visualise intra-urban air pollution and human exposure and develop air quality maps and smoke pollution management tools. It is expected to advance the evidence-based management of air as a resource, increasing economic prosperity and enhancing human health and quality of life.Read moreRead less