Does Palliative Chemotherapy Improve Symptoms In Women With Recurrent Ovarian Cancer?
Funder
National Health and Medical Research Council
Funding Amount
$521,878.00
Summary
This is a study in women who have relapsed ovarian cancer, and who are about to start further chemotherapy. Subjects will answer questions about their quality of life in order to measure any improvement in their symptoms and well being in response to palliative treatment. The study will relate subjects own reporting of improvement with their actual clinical response. The aim of this study is to develop an optimal palliative chemotherapy regime for use in future clinical trials.
Physiological And Neurophysiological Assessment Of Lip And Tongue Function For Speech In Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$356,250.00
Summary
Speech difficulties are commonly experienced by people with multiple sclerosis (MS) and can have a devastating, restrictive effect on social interactions, work and education opportunities, ultimately reducing quality of life. Research has shown that a major factor underlying impaired speech in MS is disturbed functioning of the structures that articulate speech, particularly the tongue and lips. In order to effectively treat these speech disturbances, it is imperative that the nature and severit ....Speech difficulties are commonly experienced by people with multiple sclerosis (MS) and can have a devastating, restrictive effect on social interactions, work and education opportunities, ultimately reducing quality of life. Research has shown that a major factor underlying impaired speech in MS is disturbed functioning of the structures that articulate speech, particularly the tongue and lips. In order to effectively treat these speech disturbances, it is imperative that the nature and severity of the tongue and lip impairments be identified, so that specific treatment methods can be employed to directly target those impairments. The present project will use state-of-the-art technology to track and record movements of the tongue and lips during speech and to investigate how well the neural command pathways leading from the brain to the lip and tongue muscles are functioning in persons with MS. The results of the study will direct the development of more specific and effective speech therapy procedures that will empower persons with MS with intelligible speech.Read moreRead less
Evaluation Of A Rapid Behavioural Treatment For Sleep Onset Insomnia
Funder
National Health and Medical Research Council
Funding Amount
$268,500.00
Summary
Chronic insomnia is a prevalent health problem that affects 5-10% of the population. It is associated with significant physical and mental health problems as well as lowered quality of life. By far the most common treatment for insomnia continues to be sleeping tablets despite the problems of drug dependence, daytime impairment and long term loss of effect. It is also despite the evidence that behavioural therapies are more effective in the long term. In clinical experiments stimulus control the ....Chronic insomnia is a prevalent health problem that affects 5-10% of the population. It is associated with significant physical and mental health problems as well as lowered quality of life. By far the most common treatment for insomnia continues to be sleeping tablets despite the problems of drug dependence, daytime impairment and long term loss of effect. It is also despite the evidence that behavioural therapies are more effective in the long term. In clinical experiments stimulus control therapy (SCT) is consistently the most effective of the behavioural therapies. However, SCT is difficult to carry out over the 4-6 week period necessary for effective treatment. If the treatment process could be shortened, it may increase the number of successful treatments. We have developed a laboratory procedure which includes the effective elements of SCT. These elements include sleep restriction and the experience of one rapid sleep onset each night. Our procedure involves some sleep deprivation and the experience of many (over 40) rapid sleep onsets over just one day. Therefore, it condenses 40 nights of the re-training benefits of SCT into just one day. A preliminary study has shown this procedure to be as effective as normal SCT. However, with no follow-up therapy to the procedure the initial gains tended to diminish with time. Our proposal is to test and extend the possible benefits of this new treatment procedure. We will compare it with the standard SCT as well as combine it with SCT. We feel that the greatest benefit may be to use the laboratory procedure as a kick start to SCT, which will by-pass the most difficult first 2--3 weeks of SCT. This will greatly reduce the time as well as absolutely improve the outcome. In further studies the laboratory procedure may be transferred to the patient s home, thereby further increasing its effectiveness. We feel the proposal will lead to a significant improvement in the non-drug treatment of insomnia.Read moreRead less
Comparison Of Cognitive-behavioural Treatments For Children With PTSD Following An Accidental Injury: A Multi-site RCT.
Funder
National Health and Medical Research Council
Funding Amount
$359,111.00
Summary
Children who experience a traumatic event are at increased risk of developing Post traumatic stress disorder (PTSD). Despite the significant consequences, and the poor prognosis of this disorder, few evaluations of interventions for PTSD in children exist. This project will compare two active treatments (child vs. family-focused cognitive behaviour therapy) for children experiencing PTSD following an accidental injury (the most common category of traumatic events experienced by children).
Developing A Standard Dyspnea Challenge To Explore Mechanisms And Therapies In Clinical Populations
Funder
National Health and Medical Research Council
Funding Amount
$454,383.00
Summary
COPD is Australia's most burdensome respiratory disease with over 200,000 new cases diagnosed each year. Shortness of breath is a cardinal feature of this disease.This project will examine the mechanisms of this symptom in patients with chronic lung disease. Four studies will be completed in total, each exploring different factors that may contribute to shortness of breath observed in patients. This research is likely to lead to improved management of this distressing condition into the future.
This study proposes to examine the quality of procedural medical care provided by rural doctors who are not specialists. The disciplines of Anaesthetics, Surgery and Obstetrics will be included. Most of these services in rural Australia are not provided by specialist medical practitioners, but rather by rural general practitioners who have obtained additional training, albeit shorter than that undertaken by specialist trainees, and who are supported by skilled nurses and other health professiona ....This study proposes to examine the quality of procedural medical care provided by rural doctors who are not specialists. The disciplines of Anaesthetics, Surgery and Obstetrics will be included. Most of these services in rural Australia are not provided by specialist medical practitioners, but rather by rural general practitioners who have obtained additional training, albeit shorter than that undertaken by specialist trainees, and who are supported by skilled nurses and other health professionals in relatively small rural hospitals. Patients and rural doctors often have little choice but to manage urgent cases locally and in some cases experienced and skilled local teams are able to offer a wider range of services, including a limited number of elective procedures. Despite underlying assumptions that the quality of the services cannot match that of specialist care in larger hospitals, there is no agreement on what constitutes quality of rural procedural care and little evidence that the quality is different. This issue is important as substantial government funds are spent on recruiting, training and retaining a qualified rural medical workforce, and yet fewer rural doctors are providing these services and fewer rural hospitals have the facilities to support those rural doctors still providing the services. Further, measuring the quality of care is a complex issue on which different stakeholders may have different views. This study proposes a multi-perspective approach to assessing the quality of care through a number of case studies provided by rural doctors.Read moreRead less
A Randomised Control Trial Of Non-specific Clinical Management Versus CBT In Chronic Anorexia Nervosa
Funder
National Health and Medical Research Council
Funding Amount
$555,843.00
Summary
Anorexia nervosa (AN) is a serious mental illness that usually starts in adolescence and often runs a chronic course. With an estimated prevalence rate between 0.5% and 3.7% of women, and up to 50% remaining chronically ill, the illness poses a disproportionate burden on health and social services. AN has inpatient costs alone that exceed that for schizophrenia. Chronic AN has the highest mortality rate of any mental illness. Chronic AN patients are known for their ambivalence about engaging in ....Anorexia nervosa (AN) is a serious mental illness that usually starts in adolescence and often runs a chronic course. With an estimated prevalence rate between 0.5% and 3.7% of women, and up to 50% remaining chronically ill, the illness poses a disproportionate burden on health and social services. AN has inpatient costs alone that exceed that for schizophrenia. Chronic AN has the highest mortality rate of any mental illness. Chronic AN patients are known for their ambivalence about engaging in treatment and poor motivation to change their eating disorder behaviours. They often fail to respond to traditional treatments and develop a history of negative treatment experiences and repeated treatment failures. A new approach is needed to reduce both the personal suffering and the burden of the illness on social and medical services. To date, there has been little scientific investigation into the development of specific treatment for those patients with chronic AN. This study will trial a recently manualised therapy - non-specific supportive clinical management - which initial evidence suggests may hold promise for chronic AN because it offers a more indirect, motivationally-matched approach. This treatment will be compared to the establishment therapy Cognitive Behavioural Therapy. Patients will be randomly allocated to one of the two treatment conditions and will receive 40 sessions over 12 months. They will be thoroughly assessed prior to during and after they have completed treatment and followed up for 6 months. This is the worlds first trial of a psychological treatment for chronic AN; it is hoped the study will establish an effective treatment for this debilitating and expensive illness. Further, as the project aims to explore the core, but often over-looked, feature of AN - poor motivation for recovery - it will also be in a position to shed light on the deep psychological processes that maintain this illness.Read moreRead less