A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also ....Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also have significant spillover benefits into other complex system domains, where computational tools can be used to aid in design leading to high embedded-IP products for Australian industry. Furthermore, the proposal encompasses a strong research training aspect, with graduates exposed to leading edge industry and academia.Read moreRead less
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
Variable Structure Control Systems in Networked Environments. This project will be the first in the world to lay the foundation for a new theory for understanding and designing new variable structure control systems in the networked environments, which is in great need due to increasing use of shared communication networks in modern industrial systems. It will firmly place Australia at the forefront of this research by developing a cutting edge technology for improving reliability and efficiency ....Variable Structure Control Systems in Networked Environments. This project will be the first in the world to lay the foundation for a new theory for understanding and designing new variable structure control systems in the networked environments, which is in great need due to increasing use of shared communication networks in modern industrial systems. It will firmly place Australia at the forefront of this research by developing a cutting edge technology for improving reliability and efficiency of industrial variable structure control systems in the networked environments, hence resulting in cost-saving and improved productivity for industry. It will provide training for new leading researchers specialised in this new theory and technology.Read moreRead less
The social determinants of childhood injury. Child hood injury is a preventable problem of major importance. This project will provide a comprehensive, research-based policy solution that will minimise death and disability among children zero to three years of age.
Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle d ....Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle deposition in human lung through experimental studies and advanced modelling. The program will enhance and strengthen the existing collaboration between the universities and its outcome will be of significance in the vital area of human health and risk assessment.Read moreRead less
Adaptive ecotyping of the toxic cyanobacterium Cylindrospermopsis raciborskii to predict its invasive capacity. We change the world while other organisms adapt to these new conditions. Cyanobacteria (blue green algae) increasingly dominate water bodies that were previously free of these harmful blooms. To minimise the spread of these algae, this project will study the genetic basis that determines how rapidly they can evolve and adapt to a changing planet.
Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive pla ....Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive plant-soil-based biofilters for cost-effective removal of nitrogen from a range of polluted urban water sources. The project will open a potential for a new technological advancements in urban water management, while simultaneously providing benefits to the environment and community through greening and waterway protection.Read moreRead less
DEVELOPING SCIENTIFIC BASIS FOR THE RAPID DETECTION SYSTEM OF DIESEL VEHICLES WITH HIGH LEVEL OF EXHAUST EMISSIONS. Diesel vehicle exhaust is a significant source of air pollution leading to major human health problems. However, only a small fraction of vehicles with high exhaust emissions cause the majority of this pollution. Initially, this research will develop a model of dispersion of pollutants into the environment immediately after emission. This model will be the scientific foundation for ....DEVELOPING SCIENTIFIC BASIS FOR THE RAPID DETECTION SYSTEM OF DIESEL VEHICLES WITH HIGH LEVEL OF EXHAUST EMISSIONS. Diesel vehicle exhaust is a significant source of air pollution leading to major human health problems. However, only a small fraction of vehicles with high exhaust emissions cause the majority of this pollution. Initially, this research will develop a model of dispersion of pollutants into the environment immediately after emission. This model will be the scientific foundation for the development of an efficient and economical rapid detection system for those vehicles with high exhaust emissions. The major outcome is to improve air quality and lower the occurrence/severity of airborne pollution induced health effects.Read moreRead less