Minimally invasive monitoring of sleep for disease management. Sleep, diet and exercise are the three pillars of wellbeing with poor sleep associated with medical issues such as obesity and congestive heart failure. This project will advance sleep analysis by researching new ways of monitoring that are highly accurate and convenient, enabling physicians to improve the monitoring of significant health issues.
Smart metering founding a holistic evidence-based performance evaluation framework and demand forecasting model for diversified water supply schemes. The Australian water industry faces the challenge of catering for the potable water demand of a rapidly expanding population with reduced reliability on supply imposed by an increasingly variable climate. Diversified water supply schemes (DWSS) incorporating decentralised systems or reuse sources are touted as a means to handle the inherent weaknes ....Smart metering founding a holistic evidence-based performance evaluation framework and demand forecasting model for diversified water supply schemes. The Australian water industry faces the challenge of catering for the potable water demand of a rapidly expanding population with reduced reliability on supply imposed by an increasingly variable climate. Diversified water supply schemes (DWSS) incorporating decentralised systems or reuse sources are touted as a means to handle the inherent weaknesses of centralised urban water supply schemes by potentially drawing 30-50 per cent less demand on their reserves. This research study will provide evidence to support the implementation of best practice DWSS based on an evidence based holistic assessment of their performance considering potable water savings, capital and operation costs, energy demand, as well as environmental and community impacts.Read moreRead less
The role of oxytocin in attachment patterns and socio-emotional development. The role of oxytocin in attachment patterns and socio-emotional development. This project aims to better understand how oxytocin mediates links between maternal sensitivity and attachment and child socio-emotional outcomes. The child's emotional health is the most powerful childhood predictor of adult life satisfaction, and evidence points to the pivotal role of the oxytocin system on mother-child interactions and attac ....The role of oxytocin in attachment patterns and socio-emotional development. The role of oxytocin in attachment patterns and socio-emotional development. This project aims to better understand how oxytocin mediates links between maternal sensitivity and attachment and child socio-emotional outcomes. The child's emotional health is the most powerful childhood predictor of adult life satisfaction, and evidence points to the pivotal role of the oxytocin system on mother-child interactions and attachment representations that affect children's socio-emotional development. As a longitudinal study of oxytocin function in mother-child dyads, it examines how genetic, epigenetic and parenting factors determine socio-emotional and temperamental outcomes.Read moreRead less
Metal-air batteries with improved rate capability and safety for hearing applications. Hearing impairment affects on average 20% of the adult population in western society, with the impact being as high as 50% in older adults. Effective hearing devices require a significant amount of power, supplied by a battery, to support their function. Current batteries require very frequent replacement and represent a significant impediment to advances in the technology. This project will develop improved ....Metal-air batteries with improved rate capability and safety for hearing applications. Hearing impairment affects on average 20% of the adult population in western society, with the impact being as high as 50% in older adults. Effective hearing devices require a significant amount of power, supplied by a battery, to support their function. Current batteries require very frequent replacement and represent a significant impediment to advances in the technology. This project will develop improved energy and power density batteries which will lead to immediate implementation of more powerful signal processing algorithms, making hearing aids much more effective and appealing to the user. This, in turn, will improve recipient compliance and thus the quality of life for those with severe hearing impairment. Read moreRead less
A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
A Randomised Control Trial Of Non-specific Clinical Management Versus CBT In Chronic Anorexia Nervosa
Funder
National Health and Medical Research Council
Funding Amount
$555,843.00
Summary
Anorexia nervosa (AN) is a serious mental illness that usually starts in adolescence and often runs a chronic course. With an estimated prevalence rate between 0.5% and 3.7% of women, and up to 50% remaining chronically ill, the illness poses a disproportionate burden on health and social services. AN has inpatient costs alone that exceed that for schizophrenia. Chronic AN has the highest mortality rate of any mental illness. Chronic AN patients are known for their ambivalence about engaging in ....Anorexia nervosa (AN) is a serious mental illness that usually starts in adolescence and often runs a chronic course. With an estimated prevalence rate between 0.5% and 3.7% of women, and up to 50% remaining chronically ill, the illness poses a disproportionate burden on health and social services. AN has inpatient costs alone that exceed that for schizophrenia. Chronic AN has the highest mortality rate of any mental illness. Chronic AN patients are known for their ambivalence about engaging in treatment and poor motivation to change their eating disorder behaviours. They often fail to respond to traditional treatments and develop a history of negative treatment experiences and repeated treatment failures. A new approach is needed to reduce both the personal suffering and the burden of the illness on social and medical services. To date, there has been little scientific investigation into the development of specific treatment for those patients with chronic AN. This study will trial a recently manualised therapy - non-specific supportive clinical management - which initial evidence suggests may hold promise for chronic AN because it offers a more indirect, motivationally-matched approach. This treatment will be compared to the establishment therapy Cognitive Behavioural Therapy. Patients will be randomly allocated to one of the two treatment conditions and will receive 40 sessions over 12 months. They will be thoroughly assessed prior to during and after they have completed treatment and followed up for 6 months. This is the worlds first trial of a psychological treatment for chronic AN; it is hoped the study will establish an effective treatment for this debilitating and expensive illness. Further, as the project aims to explore the core, but often over-looked, feature of AN - poor motivation for recovery - it will also be in a position to shed light on the deep psychological processes that maintain this illness.Read moreRead less
Advancing water pollution emissions modelling in cities of the future. Advancing water pollution emissions modelling in cities of the future. This project aims to advance stormwater pollution modelling and enhance its link with urban development. Management of stormwater pollution by industry often results in inadequate strategies and, crucially, sub-optimal financial investments. Since this is unlikely to improve in light of urban growth and climate change, addressing decade-old pollution model ....Advancing water pollution emissions modelling in cities of the future. Advancing water pollution emissions modelling in cities of the future. This project aims to advance stormwater pollution modelling and enhance its link with urban development. Management of stormwater pollution by industry often results in inadequate strategies and, crucially, sub-optimal financial investments. Since this is unlikely to improve in light of urban growth and climate change, addressing decade-old pollution modelling knowledge gaps and the lack of a multidisciplinary approach to stormwater pollution management is urgent. The anticipated outcome is a modelling tool which industry can use to manage stormwater pollution in changing cities through smarter and economic technology and policy.Read moreRead less
Synthetic Biology Derived Electroactive Whole Cell Microbial Biosensors. The aim of this project is to develop, using synthetic biology, electrically integrated microbial biosensors for the detection of heavy metals in the environment. Building on our existing technology, this project aims to produce novel ‘biobricks’ capable of electrically integrating electric microbes into real time environmental monitors for heavy metal contaminants. This expansion of synthetic biology, and integration of el ....Synthetic Biology Derived Electroactive Whole Cell Microbial Biosensors. The aim of this project is to develop, using synthetic biology, electrically integrated microbial biosensors for the detection of heavy metals in the environment. Building on our existing technology, this project aims to produce novel ‘biobricks’ capable of electrically integrating electric microbes into real time environmental monitors for heavy metal contaminants. This expansion of synthetic biology, and integration of electric bacteria into sensor systems, will result in a new platform technology that expands our abilities to protect the ecology, agriculture and health of terrestrial, marine and agricultural at risk areas from economic and environmental damage.Read moreRead less
Deeper and broader life cycle risk assessment - extending the frontier for hybrid methodologies. This project is about combining detailed and global perspectives of environmental health risk from different fields of planning practice. It aims to improve the depth and breadth of the types of information used by government regulators and the community in decisions about the development of capital works.