Clinical Outcomes, Safety And Incremental Cost Effectiveness Of Multi-level Airway Surgery In Patients With Moderate-severe Obstructive Sleep Apnea (OSA) Who Have Failed Medical Management
Funder
National Health and Medical Research Council
Funding Amount
$652,794.00
Summary
Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to ....Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to improved patient outcomes.Read moreRead less
Airway Epithelial IAPs And Their Interaction With Zn Ions
Funder
National Health and Medical Research Council
Funding Amount
$260,779.00
Summary
The air we breathe contains a variety of harmful substances. Damage to the lining involves death of the ciliated cells that line the airways. We have shown that zinc protects these cells from premature death. This application focuses on a family of proteins called IAPs which bind zinc and regulate cell death in other tissues. This project focusses on how the IAPs and Zn may act together to mainitain healthy airways and how abnormalities of these may occur in people with asthma.
Role Of Zinc In The Respiratory Epithelium And Asthma
Funder
National Health and Medical Research Council
Funding Amount
$224,250.00
Summary
This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example ....This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example, asthma affects 12% of adults and amongst these, 15% waken weekly or more often with their asthma while 6% are hospitalized annually. There is a need to understand the basic mechanisms underlying these diseases so that new strategies can be developed to modify bronchocondtriction and inflammation. The project will provide new knowledge concerning the physiology of Zn in the respiratory epithelium and interactions between Zn deficiency and oxidants on injury in the respiratory tract. The usefulness of easily accessible nasal epithelial cells as a measure of Zn and Zn transporter levels deeper in the respiratory tract will be assessed. The project encompasses a number of fields and utilizes in vitro cellular and animal models, as well as tissues from human subjects.Read moreRead less
Groundwater flow age distributions: Understanding open pit mine hydrology. This project aims to improve the estimation of the age of groundwater. Understanding groundwater age is critical for sustainable management and environmental tracers are increasingly used for this purpose. However, groundwater samples are inevitably mixtures of water of different ages. Since for most tracers the relationship between tracer concentration and age is not linear, different tracers can produce different mean a ....Groundwater flow age distributions: Understanding open pit mine hydrology. This project aims to improve the estimation of the age of groundwater. Understanding groundwater age is critical for sustainable management and environmental tracers are increasingly used for this purpose. However, groundwater samples are inevitably mixtures of water of different ages. Since for most tracers the relationship between tracer concentration and age is not linear, different tracers can produce different mean ages for the sample. This project aims to determine whether it is possible to determine moments of the groundwater age distributions from measurements made with different environmental tracers. The project also aims to examine whether the degree of heterogeneity within the aquifer can be determined from the disparity between ages obtained with different tracers. This project aims to tackle the largest problem with using groundwater chemistry to estimate water age – that mixing processes in the subsurface are never known. Solving this problem will allow much more accurate estimates of groundwater velocity and aquifer recharge rates. The groundwater industry contributes an estimated $6.8 billion per annum to the Australian economy, and this project will contribute to the sustainable management of the groundwater resource.Read moreRead less
Unlocking the secrets of the groundwater cycle using Si and Li isotopes. This project aims to determine how non-conventional lithium and silicon isotopes can be used to understand groundwater processes using an innovative source-to-target approach. The project aims to apply these isotope tracers to trace the water cycle within a well constrained system: an island aquifer with a dense borefield which has been analysed using traditional isotopic techniques. Supporting hydrochemical data will be us ....Unlocking the secrets of the groundwater cycle using Si and Li isotopes. This project aims to determine how non-conventional lithium and silicon isotopes can be used to understand groundwater processes using an innovative source-to-target approach. The project aims to apply these isotope tracers to trace the water cycle within a well constrained system: an island aquifer with a dense borefield which has been analysed using traditional isotopic techniques. Supporting hydrochemical data will be used to determine the relationship of the isotopes with environmental processes. The project impact will be the development of new methods to help understand our groundwater resource. The improved process understanding will be translated to groundwater management in general. The projects' focus on carbonate aquifer systems typical of coastal regions of southern, eastern and western Australia will have relevance to groundwater management in urban areas such as Perth and in rural areas for tourism and viticulture, and for management of natural resources in National Parks.Read moreRead less
East Australian climate extremes through the Holocene. The project aims to document climate variability in eastern Australia over the Holocene, the last 11,500 years. It seeks to develop Australia’s two highest-resolution Holocene climate records using novel techniques to infer past rainfall, temperature and evaporation. The project will combine the expertise of international drought and climate specialists with novel techniques developed by the Australian investigators to derive an unparalleled ....East Australian climate extremes through the Holocene. The project aims to document climate variability in eastern Australia over the Holocene, the last 11,500 years. It seeks to develop Australia’s two highest-resolution Holocene climate records using novel techniques to infer past rainfall, temperature and evaporation. The project will combine the expertise of international drought and climate specialists with novel techniques developed by the Australian investigators to derive an unparalleled record of drought duration, frequency and intensity. In particular, the project aims to determine the frequency, duration and causes of mega-droughts in eastern Australia, of which little is known. Expected project outcomes include improved decision making capacity for natural resource management, and planning.Read moreRead less
Revolutionising The Diagnosis And Monitoring Of CF Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$818,391.00
Summary
Cystic fibrosis (CF) lung disease starts early in childhood and relentlessly progresses, with early death a common outcome. There is currently no method capable of detecting very early disease onset nor directly assessing the effectiveness of putative treatments. This project will apply our globally unique X-ray imaging tools, which are capable of imaging lung function at any point across the entire lung, for the very early detection of CF and assessment of clinically applicable treatments.
Meals on Wheels: building towards a new social experiment for our times. This project contributes directly to the National Research Priority, promoting and maintaining good health: ageing well, ageing productively, through developing evidence-based knowledge on which to build future volunteer business models. With the rapid ageing of the Australian population, it is imperative that volunteer-based organisations, such as Meals on Wheels, innovate to continue to deliver essential community service ....Meals on Wheels: building towards a new social experiment for our times. This project contributes directly to the National Research Priority, promoting and maintaining good health: ageing well, ageing productively, through developing evidence-based knowledge on which to build future volunteer business models. With the rapid ageing of the Australian population, it is imperative that volunteer-based organisations, such as Meals on Wheels, innovate to continue to deliver essential community services in a sustainable and cost-effective way. Meals on Wheels is integral within community care for frail, older people and those with disabilities, keeping people in their own homes and out of institutional care. Using national and international examples, the research has the potential to be adopted by the broad community services sector in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100047
Funder
Australian Research Council
Funding Amount
$540,000.00
Summary
A multi-frequency microwave radiometer system for environmental research. A multi-frequency microwave radiometer system for environmental research: A new capability for airborne remote sensing of key environmental variables will be established. The unique P-, Ku- and Ka-band passive microwave radiometer system will provide information on soil moisture, surface temperature and vegetation, and allow for a new satellite concept to be demonstrated. By combining with an existing L-band radiometer, da ....A multi-frequency microwave radiometer system for environmental research. A multi-frequency microwave radiometer system for environmental research: A new capability for airborne remote sensing of key environmental variables will be established. The unique P-, Ku- and Ka-band passive microwave radiometer system will provide information on soil moisture, surface temperature and vegetation, and allow for a new satellite concept to be demonstrated. By combining with an existing L-band radiometer, data can be collected simultaneously at P-, L-, Ku- and Ka-bands, with increased spatial resolutions accordingly. The shorter wavelength, but higher spatial resolution data can be used to enhance the spatial resolution of the longer wavelength data, resulting in a capability to derive long wavelength observations from space at unprecedented spatial resolution.Read moreRead less