Approach To Address Socioeconomic Inequality In Oral Health
Funder
National Health and Medical Research Council
Funding Amount
$773,033.00
Summary
This research program is expected to contribute to filling significant gaps in the understanding of factors determining the oral health of Australian preschool children. The inter-relationship between factors potentially important for child oral health and their effect on oral health will be evaluated. The findings will help to re-evaluate the effectiveness and safety of oral health preventive programs used for children and to explain inequality in oral health of children.
Determinants Of Inequality In Child Oral Health At School Age–A Prospective Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$1,229,853.00
Summary
This study aims to examine effects of socioeconomic circumstances as determinants of child oral health conditions, which can be mediated by dietary patterns, use of fluoride and dental service.
Understanding Influences On Oral Health Of Contemporary Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
This study will contribute to an understanding of the factors affecting child oral health. Findings will have scientific value and relevance for the policy-making process in developing new methods of oral health prevention to target modifiable factors that will lead to improvement of oral health of children
Randomised Control Trial Of Effectiveness Of Silver Fluoride In Managing Deciduous Dental Caries In Remote Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$695,220.00
Summary
This study seeks to test a non-invasive treatment for dental decay in young children which may prevent the progression of the decay further into the tooth. This treatment is currently used in some areas. Dental decay is very common in young children in remote communities where access to dental care is often limited. The treatment may reduce pain and oral and facial infections sometimes leading to hospitalisation.
Impact Of Health Policy On The Delivery Of Dental Services And Child Oral Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$1,304,799.00
Summary
This project will study the use of dental services by children and adolescents in Australia and how use relates to oral health outcomes. Variation in the support for the use of private dentists and the organisation and delivery of school dental services will be compared both within and across all states and territories so as to inform policy discussions on how to best improve child oral health.
A New Target For Allergic Inflammation: The Sphingolipid Pathway
Funder
National Health and Medical Research Council
Funding Amount
$588,617.00
Summary
Collectively, allergic diseases contribute immensely to the burden of health care in Australia. Notably, allergic reactions are symptomatic responses to a normally innocuous environmental antigen. Allergic diseases include asthma, hay fever, food allergy, anaphylaxis, insect sting and drug allergy. This project aims to understand the underlying mechanisms associated with allergic reactions such that it may aid in the identification of novel targets for the development of new treatments.
Role Of Zinc In The Respiratory Epithelium And Asthma
Funder
National Health and Medical Research Council
Funding Amount
$224,250.00
Summary
This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example ....This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example, asthma affects 12% of adults and amongst these, 15% waken weekly or more often with their asthma while 6% are hospitalized annually. There is a need to understand the basic mechanisms underlying these diseases so that new strategies can be developed to modify bronchocondtriction and inflammation. The project will provide new knowledge concerning the physiology of Zn in the respiratory epithelium and interactions between Zn deficiency and oxidants on injury in the respiratory tract. The usefulness of easily accessible nasal epithelial cells as a measure of Zn and Zn transporter levels deeper in the respiratory tract will be assessed. The project encompasses a number of fields and utilizes in vitro cellular and animal models, as well as tissues from human subjects.Read moreRead less