A New Paradigm For Class I Cytokine Receptor Activation
Funder
National Health and Medical Research Council
Funding Amount
$954,946.00
Summary
Class I cytokine receptors include around 30 receptors with diverse functions such as controlling metabolism and inflammation. Cytokine receptors are molecular switches on cells that receive signals from other cells and transmit this signal into the cell’s nucleus to control the regulation of genes. This project will determine the molecular mechanisms involved in class I cytokine receptors and use this knowledge to develop novel ways to modulate these receptors for clinical applications.
Macrophage Polarisation And Control Of Pulmonary Inflammation.
Funder
National Health and Medical Research Council
Funding Amount
$895,494.00
Summary
As key immune cells, macrophages are polarised to phenotypes that turn inflammation on or off. In cystic fibrosis, defective macrophage polarisation enhances inflammation and prevents lung repair. We are defining the molecules and cellular pathways that control this process and identifying targets for existing drugs that can be used to reprogram macrophages and restore lung repair to improve patient outcomes.
Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suic ....Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suicide risk; use these systems to investigate how different situational factors interact with different combinations of service interventions to influence suicide risk; and share the findings to reduce railway suicide in Australia and overseas.Read moreRead less
Service Ecosystems Management for Collaborative Process Improvement. Australian government agencies currently explore opportunities for streamlining their business processes. A promising approach relates to the improvement of cross-agency processes based on service-enabled technologies. This project will use requirements within Queensland Government for the design of a service ecosystem and methodological and management concepts to derive a general framework for intra-organisational ecosystems. ....Service Ecosystems Management for Collaborative Process Improvement. Australian government agencies currently explore opportunities for streamlining their business processes. A promising approach relates to the improvement of cross-agency processes based on service-enabled technologies. This project will use requirements within Queensland Government for the design of a service ecosystem and methodological and management concepts to derive a general framework for intra-organisational ecosystems. Though the focus will be on government processes, the project will generalise beyond this scope for a wider uptake of service ecosystems in Australian organisations. This will lead to reduced process costs and risks and will leverage the exploration of new revenue streams, e.g. shared services and reward schemes.Read moreRead less
Expressiveness Comparison and Interchange Facilitation between Business Process Execution Languages. Developments in the area of business process management are currently hindered by the plethora of diverse business process execution languages. This project will develop techniques for dealing with interoperability issues induced by this language heterogeneity. The project combines theoretical research, grounded in concurrency theory and workflow patterns, with pragmatic research focusing on lang ....Expressiveness Comparison and Interchange Facilitation between Business Process Execution Languages. Developments in the area of business process management are currently hindered by the plethora of diverse business process execution languages. This project will develop techniques for dealing with interoperability issues induced by this language heterogeneity. The project combines theoretical research, grounded in concurrency theory and workflow patterns, with pragmatic research focusing on languages supported by commercial tools. The outcome will be a framework for comparing the expressiveness of process execution languages and defining mappings between them. This will place Australia at the forefront of developments in business process management systems: a crucial technology in today's global, dynamic, and heterogeneous environments.
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UNLOCKING BENEFITS FROM ENTERPRISE SYSTEMS IN THE AUSTRALIAN PUBLIC SECTOR: Benefits Realisation in the Context of the Virtual Organisation. This study proposes to provide an innovative Virtual Organisation perspective to identify factors that can assist Australian government agencies to maximise the potential benefits from Enterprise System (ES) implementation. Study aims include: Identify and explicate major characteristics of the Virtual Organisation created through collaboration between gove ....UNLOCKING BENEFITS FROM ENTERPRISE SYSTEMS IN THE AUSTRALIAN PUBLIC SECTOR: Benefits Realisation in the Context of the Virtual Organisation. This study proposes to provide an innovative Virtual Organisation perspective to identify factors that can assist Australian government agencies to maximise the potential benefits from Enterprise System (ES) implementation. Study aims include: Identify and explicate major characteristics of the Virtual Organisation created through collaboration between government agency and (external) ES Implementation Partner; Identify and document features and constraints peculiar to ES implementation in the Australian public sector; Identify and explicate factors impacting on benefits realisation, relating these to theory from related fields; Highlight consensus and difference among stakeholders; Develop a validated, repeatable methodology for major impact studies; Inform ES research directions.Read moreRead less
Reconceptualising the information system as a service. Through parallel efforts in Australia and China, the study aims to propel 'IS-Impact', the Australia-originated and most extensively validated IS success measurement model, to become the Information Systems evaluation approach of choice globally, in both research and practice.
Mapping Trusted Systems Technologies to E-security Requirements. A new software based approach, strongly guided by national and international security standards based upon mandatory access control, is required to simplify for management the protection of their information infrastructure. This will be in the form of a security definition toolset aligned to trusted systems technologies currently under consideration internationally. No such trusted system has been developed to address current comme ....Mapping Trusted Systems Technologies to E-security Requirements. A new software based approach, strongly guided by national and international security standards based upon mandatory access control, is required to simplify for management the protection of their information infrastructure. This will be in the form of a security definition toolset aligned to trusted systems technologies currently under consideration internationally. No such trusted system has been developed to address current commercial IT product environments. The safety and security of information systems against attack and illicit usage form an essential component of ?National Information Infrastructure Protection (NIIP)?, a move to better ?e-security?. Existing commercial (untrusted) operating systems lack the critical security bases for e-security making e-applications vulnerable to tampering and bypass which can cause failures in overall system security.Read moreRead less
A theory of communicative practices within financial internet discussion site communities. This project aims to use online financial investment communities to identify factors that drive communication and influence knowledge co-creation, examine how systematic variations in these factors influence investor decision making, and develop a mid-range theory for explaining and predicting the influence of online communication patterns on individual decisions and market outcomes. By developing and vali ....A theory of communicative practices within financial internet discussion site communities. This project aims to use online financial investment communities to identify factors that drive communication and influence knowledge co-creation, examine how systematic variations in these factors influence investor decision making, and develop a mid-range theory for explaining and predicting the influence of online communication patterns on individual decisions and market outcomes. By developing and validating a new mid-range theory, initially in the financial investment context, this project will provide significant benefits, such as help to secure Australia’s place in a changing world through improved information flow.Read moreRead less