CKD-FIX: A Randomised, Controlled Trial Of Allopurinol In The Slowing Of Kidney Disease Progression
Funder
National Health and Medical Research Council
Funding Amount
$1,917,147.00
Summary
Chronic kidney disease (CKD) is a major public health problem affecting over 1.5 million Australians and is associated with increased risk of death, heart disease and progression to end-stage kidney disease (ESKD). Current treatments to slow progression to ESKD are limited. The CKD-FIX trial aims to find out whether treatment with allopurinol, a commonly used drug for gout prevention, safely and effectively slows CKD progression. This could lead to significant health and economic benefits.
Enhancing Erythropoietin Therapy In Ischaemia-reperfusion Injury Of Heart And Kidney
Funder
National Health and Medical Research Council
Funding Amount
$361,021.00
Summary
Heart attacks and kidney disease from a lack of blood flow are common causes of morbidity and have poor treatment options. Erythropoietin (epo) is a useful new treatment, but there remain some caveats to its use in humans: eg. it may cause excessive scarring during repair. Use of epo with an anti-inflammatory drug may decrease scarring and provide benefit to long-term health. We plan to carefully define the biomolecular pathways of injury and repair, to better plan this therapy for human use.
AusDiab 3: Emerging Risk Factors For And Long-term Incidence Of Cardio-metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,616,397.00
Summary
This study will track 11,000 Australian adults over 12 years to determine how many develop diabetes, obesity, kidney and heart disease. The study will develop ways to best predict those who are going to develop these conditions before they have arisen, and will explore a range of novel risk factors to better understand these conditions.
Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Enhancing aquaculture production of the tropical abalone using complementary genetic and environmental approaches. While temperate abalone are one of our most valuable seafoods, there is a growing demand worldwide for the ?cocktail?-sized tropical abalone Haliotis asinina. Australia is well positioned to capture the market for this rapidly growing species. We propose to enhance the already favourable growth rates of Haliotis asinina in aquaculture by delineating critical environmental and geneti ....Enhancing aquaculture production of the tropical abalone using complementary genetic and environmental approaches. While temperate abalone are one of our most valuable seafoods, there is a growing demand worldwide for the ?cocktail?-sized tropical abalone Haliotis asinina. Australia is well positioned to capture the market for this rapidly growing species. We propose to enhance the already favourable growth rates of Haliotis asinina in aquaculture by delineating critical environmental and genetic factors that effect production. This proposal uniquely melds commercial production practices at MG Kailis Export Pty Ltd with expertise in aquaculture and marine biotechnology present at The University of Queensland and CSIRO Marine Research. This knowledge will enhance the development of this new aquaculture industry in tropical Australia.Read moreRead less
Improving likelihood estimators: theory and applications to analysing productivity and efficiency and forecasting of probability of economic recession. This project aims to improve one of the most popular statistical methods to empower applied researchers with a more reliable analytical tool. This project will develop mathematical theory and use it to analyse patterns of economic growth, productivity and efficiency of countries. This can be used to forecast probability of entering economic reces ....Improving likelihood estimators: theory and applications to analysing productivity and efficiency and forecasting of probability of economic recession. This project aims to improve one of the most popular statistical methods to empower applied researchers with a more reliable analytical tool. This project will develop mathematical theory and use it to analyse patterns of economic growth, productivity and efficiency of countries. This can be used to forecast probability of entering economic recession, with a focus on Australia.Read moreRead less