Mineralocorticoid Receptors - Mechanisms Of Ligand- And Tissue- Specific Activation
Funder
National Health and Medical Research Council
Funding Amount
$126,848.00
Summary
Heart disease is a major cause of death and economic burden in Australia and throughout the world. The steroid hormone aldosterone controls salt and water balance, blood pressure and has a significant role in heart failure. Although drugs that block the aldosterone receptor significantly help patients with heart failure, their use is limited by side effects. This work will identify the profile of proteins that promote aldosterone effects and enable the development of heart-specific blockers.
The Role Of Angiotensin-(1-7), Angiotensin Converting Enzyme-2 And The Mas Receptor In Liver Fibrosis And The Development And Maintenance Of Portal Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Chronic liver disease is widespread in our community, and is increasing due to fatty liver disease and viral hepatitis. Liver disease leads to permanent liver scarring, liver cancer and other life-threatening complications. This research investigates the role of a hormone system called the renin-angiotensin system in liver disease, and investigated the use of drugs that act on this system for the prevention and treatment of liver scarring and these complications.
Microvascular Complications Of Diabetes - Potential Role Of Regenerative Therapies
Funder
National Health and Medical Research Council
Funding Amount
$32,003.00
Summary
The global burden of diabetes is projected to reach more than 366 million by 2025. According to the AusDiab 2005 study, each year 0.8% of Australians develop diabetes. Diabetes is the leading cause of end-stage kidney disease in Australia. Current treatments slow damage to the kidney, but do not reverse kidney damage. We will explore the potential for adult progenitor cells (endothelial progenitor cells) to reverse damage to the kidney and restore its function.