Protein Kinases Regulate Salt Reabsorption In The Kidney
Funder
National Health and Medical Research Council
Funding Amount
$531,696.00
Summary
This proposal is designed to determine how the kidney senses the level of salt in the body and monitors blood pressure. This is critical for diseases such as hypertension, kidney and heart failure, where salt is retained inappropriately. We propose that the kidney uses proteins called kinases that are activated by salt in the kidney. When it is too low, they detect this and cause the kidney to absorb more salt to correct the deficiency. The way that they are able to do this has profound implicat ....This proposal is designed to determine how the kidney senses the level of salt in the body and monitors blood pressure. This is critical for diseases such as hypertension, kidney and heart failure, where salt is retained inappropriately. We propose that the kidney uses proteins called kinases that are activated by salt in the kidney. When it is too low, they detect this and cause the kidney to absorb more salt to correct the deficiency. The way that they are able to do this has profound implications for human heart and kidney disease, and biology in general.Read moreRead less
The Role Of Fatty Acid Metabolism In Renin Secretion
Funder
National Health and Medical Research Council
Funding Amount
$582,294.00
Summary
People who are overweight often have high blood pressure. This project aims to find out why. By showing that the kidneys, which control blood pressure, use fat as an important controller of their function, we may be able to work out ways to modify the relationship between obesity and high blood pressure. The project wil be performed in genetically modified mice, but we expect that the findings will be applicable to humans.