Time dependent stratified flows in a differentially heated cavity under realistic conditions. Flows driven by the application of a horizontal temperature gradient has applications in nature and engineering. Although much progress has been made in the analysis of the case of a sudden application of temperature differences to the vertical walls of a container with insulating horizontal walls containing an isothermal fluid, the reality is that neither the insulated walls nor the initially isotherma ....Time dependent stratified flows in a differentially heated cavity under realistic conditions. Flows driven by the application of a horizontal temperature gradient has applications in nature and engineering. Although much progress has been made in the analysis of the case of a sudden application of temperature differences to the vertical walls of a container with insulating horizontal walls containing an isothermal fluid, the reality is that neither the insulated walls nor the initially isothermal fluid can be achieved. This project will, by analytical, numerical and experimental methods, make a preliminary investigation of the influence of conducting horizontal walls and an initially stratified fluid.Read moreRead less
Enhancing natural convection heat transfer using a single horizontal non-metallic fin. This project will develop the basis for a simple design to improve the energy efficiency of natural convection heat exchangers. Heat exchangers are widely adopted in many electronic devices and industrial processes as they require no external power input, additional space, and are quiet, reliable and economical. The research will exploit the interaction between two flows to trigger turbulence, and will result ....Enhancing natural convection heat transfer using a single horizontal non-metallic fin. This project will develop the basis for a simple design to improve the energy efficiency of natural convection heat exchangers. Heat exchangers are widely adopted in many electronic devices and industrial processes as they require no external power input, additional space, and are quiet, reliable and economical. The research will exploit the interaction between two flows to trigger turbulence, and will result in an increase of the overall capacity and performance of engineering systems. This will contribute significantly to reductions in power consumption and improvements in productivity and work environment, leading ultimately to reductions in greenhouse gas emissions and to economic benefits.Read moreRead less
Design tools for optimising data centre layout to minimise energy usage. Data centres are major consumers of energy worldwide, mainly through the need to cool the equipment. It has become imperative to develop the science for reducing this consumption. Rising computing demand, increasing power density, and increasing infrastructure and energy costs are major issue for data centres around the world. Our research will provide a powerful alternative to conventional thermal management techniques for ....Design tools for optimising data centre layout to minimise energy usage. Data centres are major consumers of energy worldwide, mainly through the need to cool the equipment. It has become imperative to develop the science for reducing this consumption. Rising computing demand, increasing power density, and increasing infrastructure and energy costs are major issue for data centres around the world. Our research will provide a powerful alternative to conventional thermal management techniques for cooling high-density heat loads in mixed-density environments. We will address the key issue of energy minimisation through a detailed flow analyses by the use of numerical simulations and optimisation algorithms.Read moreRead less
Modelling of unsteady natural convection in a reservoir sidearm. Horizontal exchange flows induced by daytime heating and night-time cooling through water surface play an important role in the transport of water properties in the shoreline regions of reservoirs. This project is aimed at exploring the driving mechanisms of these flows through a closely linked experimental, numerical and analytical research program. At the completion of this project, significant advance in experimental methodology ....Modelling of unsteady natural convection in a reservoir sidearm. Horizontal exchange flows induced by daytime heating and night-time cooling through water surface play an important role in the transport of water properties in the shoreline regions of reservoirs. This project is aimed at exploring the driving mechanisms of these flows through a closely linked experimental, numerical and analytical research program. At the completion of this project, significant advance in experimental methodology will be achieved, and reliable experimental and theoretical data will be available that can be used to estimate the heat and mass transfer in the coastal regions which is important for water quality management and environmental planning.Read moreRead less
Bacterial Pathogenomics: Whole-genome Sequencing To Investigate Infection Transmission, Pathogenesis And Antibiotic Resistance
Funder
National Health and Medical Research Council
Funding Amount
$475,946.00
Summary
As bacterial superbugs – resistant to multiple antibiotics – dominate the headlines, the pipeline for new antibiotics has all but dried up. High-throughput DNA sequencing heralds a golden opportunity for infectious disease research. By studying the entire collection of genes - the genome - of large numbers of multidrug resistant bacterial strains, we aim to better understand the genetic changes that govern the emergence and global spread of superbugs and translate these findings into the clinic.
Natural convection induced exchange flows between near shore and central regions of reservoirs. Inland discharges into reservoirs often carry rich nutrients, pollutants and biological species into the coastal regions, which are redistributed across the central regions of reservoirs through dynamical mixing processes. One of the important mixing processes is the horizontal exchange flow between the near shore and central regions induced by diurnal heating and cooling through the water surface, wh ....Natural convection induced exchange flows between near shore and central regions of reservoirs. Inland discharges into reservoirs often carry rich nutrients, pollutants and biological species into the coastal regions, which are redistributed across the central regions of reservoirs through dynamical mixing processes. One of the important mixing processes is the horizontal exchange flow between the near shore and central regions induced by diurnal heating and cooling through the water surface, which is classified as a natural convection process. This process will be investigated in this project through a closely linked analytical, experimental and numerical research program. The output from this research will have direct application in water quality management and environmental planning.Read moreRead less
Transport by Natural Convection in Reservoir Sidearms. This project is a first step in developing models of the distribution of water quality parameters in reservoirs by a range of small scale dynamical processes not included in commercial water quality models. Specifically, the project will investigate the transport of suspended materials from the shore to the deeper parts resulting from the interaction of the meteorological forcing and the topography. This will contribute to the development of ....Transport by Natural Convection in Reservoir Sidearms. This project is a first step in developing models of the distribution of water quality parameters in reservoirs by a range of small scale dynamical processes not included in commercial water quality models. Specifically, the project will investigate the transport of suspended materials from the shore to the deeper parts resulting from the interaction of the meteorological forcing and the topography. This will contribute to the development of improved water quality models, and therefore to better management of water quality of Australia's water resources.Read moreRead less
Evolution And Pathogenicity Of NDM-1 Positive Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$643,275.00
Summary
Antibiotic resistance (AR), as highlighted by the WHO, is the most pressing medical need of the 21C – some infections are now untreatable. Our research will focus on the new "superbug" NDM-1 positive E. coli. We will correlate AR and pathogenicity and explore the evolution of these "superbugs" using state-of-the-art sequencing. This research will benefit Australian medicine by predicting timelines of AR epidemics and by conducting the first analyses on the virulence potential of these strains.
Understanding The Role Of The Two Major Bacterial Pathogens In The Upper And Lower Airways Of Indigenous Children With Chronic Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$743,282.00
Summary
Lung infections are a major disease burden worldwide. Indigenous Australians are affected more; adults with severe lung disease can die in their 30s and 40s. These diseases start early, yet no in-depth studies of bacteria causing lung infections in children have been done. Our expert team proposes to use existing lung fluids from nearly 500 children with chronic lung disease (58% Indigenous), and state-of-the-art laboratory methods, to inform the design of vaccines to prevent lung disease.
Use Of Molecular Resistance Assays To Provide Alterative Oral Treatment Strategies For Gonorrhoea In Indigenous And Other High-risk Populations; A Randomised Cluster Trial
Funder
National Health and Medical Research Council
Funding Amount
$828,671.00
Summary
Gonorrhoea has now developed resistance to almost all antibiotics that have been used to treat it. In this study, we will investigate a new treatment approach that selects antibiotics on a patient-by-patient basis. We will use new molecular assays to first test if a gonorrhoea strain infecting a patient is susceptible to an antibiotic, and will then treat on the basis of this result. By doing so, we will optimize our use of antibiotics and improve treatment strategies for gonorrhea.