Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Economically efficient green logistics through cyber physical systems. Economically efficient green logistics through cyber physical systems. This project aims to realize green logistics by researching how to run diesel-powered heavy-duty milk trucks economically and efficiently on liquefied natural gas (LNG) and demonstrating to logistics companies that LNG conversion will reduce operating costs and emissions. Transportation systems account for 18% of Australia's carbon emissions, and diesel-po ....Economically efficient green logistics through cyber physical systems. Economically efficient green logistics through cyber physical systems. This project aims to realize green logistics by researching how to run diesel-powered heavy-duty milk trucks economically and efficiently on liquefied natural gas (LNG) and demonstrating to logistics companies that LNG conversion will reduce operating costs and emissions. Transportation systems account for 18% of Australia's carbon emissions, and diesel-powered logistics vehicles are a major contributor. However, converting these trucks to LNG requires strong evidence to convince logistics companies of the benefits of shifting to green logistics. An increase in logistics productivity is expected to increase Australia’s gross domestic product by $2 billion, while this research should also provide vital data on sustainability issues and LNG conversions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100035
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Hyperpolarised gas functional lung and molecular imaging. This project will produce a polariser to generate magnetised gas for research with magnetic resonance imaging (MRI). This allows imaging of normal and abnormal lung ventilation and circulation in animal and humans. The use of these hyperpolarised gases can also be used to tag specific molecules and increase understanding of lung metabolism.
Diseases caused by the pneumococcus represent the largest cause of vaccine preventable death in the world today, mainly pneumonia and meningitis. In 2011, 16 developing countries will introduce pneumococcal conjugate vaccines, none in east Asia. Lack of research has been a major barrier to their use in the region. We have established an international centre of excellence in the field and we seek support to extend the capacity of this group and to transfer the technology to Vietnam.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
Impact Of DTP Schedules On The Immunogenicity Of 2 Doses Of 13v-PCV Followed By An Early Booster
Funder
National Health and Medical Research Council
Funding Amount
$2,651,687.00
Summary
This project aims to come up with a vaccination schedule to make pneumococcal vaccines more effective and affordable for Fiji and other developing countries. We will evaluate schedules involving a 2 dose primary series in early infancy with a booster at 9 months of age. We will compare the immune responses to 3 different primary series and 2 booster options. The results of this project will be used to provide advice, at global and country levels, regarding introduction of pneumococcal vaccines.
Digitally-Integrated Smart Sensing of Diverse Airborne Grass Pollen Sources. Grass pollen is the main outdoor allergen source globally, triggering hayfever and asthma in up to 500 million people. With over 10,000 species, the influence of grass type, location and climate on pollen in the air is not yet known. This is a key issue since subtropical and temperate grasses differ in response to environmental factors. The project aims to use artificial intelligence on digital camera images to learn to ....Digitally-Integrated Smart Sensing of Diverse Airborne Grass Pollen Sources. Grass pollen is the main outdoor allergen source globally, triggering hayfever and asthma in up to 500 million people. With over 10,000 species, the influence of grass type, location and climate on pollen in the air is not yet known. This is a key issue since subtropical and temperate grasses differ in response to environmental factors. The project aims to use artificial intelligence on digital camera images to learn to see local grass flowers and integrate this with air sensors trained to detect grass pollen types. The expected outcomes are new capacities to track airborne grass pollen types. These outcomes can transform how pollen can be monitored to reduce the burden of allergies, and provide evidence of changing airborne pollen loads.
Read moreRead less