Treating tuberculosis: targeted delivery of multidrug nano-suspensions. Tuberculosis (TB) is a lung disease of worldwide prevalence. Treatment times are long and mortality is high in children and the elderly. Current treatments are ineffective and drug resistant TB is a real pandemic threat. The project will develop a cost-effective nano-particle system that can be incorporated into conventional nebulisers for use worldwide.
Enabling aerosol delivery of phages to defeat antibiotic-resistant bacteria. This project aims to explore the use of bacteriophages towards producing a safe, natural, and highly effective alternative to traditional antibiotics. Respiratory infections caused by multidrug-resistant Gram-negative bacteria are a major health problem worldwide, and cost Australia over $150 million annually. Some 5,000 Australians die each year from antibiotic resistant infections. The project aims to produce efficac ....Enabling aerosol delivery of phages to defeat antibiotic-resistant bacteria. This project aims to explore the use of bacteriophages towards producing a safe, natural, and highly effective alternative to traditional antibiotics. Respiratory infections caused by multidrug-resistant Gram-negative bacteria are a major health problem worldwide, and cost Australia over $150 million annually. Some 5,000 Australians die each year from antibiotic resistant infections. The project aims to produce efficacious and stable formulations of bacteriophages for easy delivery by inhalation as aerosols with a long shelf-life, making them a commercially viable product. The expected research outcome can lead to an economic and efficient technology to produce phage powders for novel treatment strategies of infections by inhalation.Read moreRead less
Future Industries Research - Biotechnology and Nanotechnology: Small talk: Communication networks in microbes. We will use the Australian Proteome Analysis Facility to address the multifaceted mechanisms of microbial interactions and produce new knowledge about the pathogen Pseudomonas aeruginosa, a common cause of death in cystic fibrosis patients. We will characterise the interactions between P. aeruginosa and the emerging fungal pathogen Scedosporium aurantiacum as a proactive step towards be ....Future Industries Research - Biotechnology and Nanotechnology: Small talk: Communication networks in microbes. We will use the Australian Proteome Analysis Facility to address the multifaceted mechanisms of microbial interactions and produce new knowledge about the pathogen Pseudomonas aeruginosa, a common cause of death in cystic fibrosis patients. We will characterise the interactions between P. aeruginosa and the emerging fungal pathogen Scedosporium aurantiacum as a proactive step towards better understanding of pathogen communication. Improved understanding of pathogen interactions should facilitate the development of novel anti-adhesives as therapeutics. Our project will train young scientists in a new integrated approach to biology.Read moreRead less