Stress-induced Genomic Instability As A Driver Of Adaptive Responses In Human Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$690,426.00
Summary
Growing experimental evidence suggests human cancer cells use evolutionary conserved programs to regulate their mutation rates in response to pharmacological agents, accelerating adaptation and the emergence of resistance. The purpose of our study is to identify the common molecular pathways and genetic mechanisms driving the regulation of mutation rates. Targeting of these pathways using a new generation of “anti-evolution” drugs is an attractive possibility for novel therapeutic approaches.
Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings in ....Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings into the blueprint for a next-generation infectious disease surveillance system for Australia. We will use a simulation-evaluation approach, coupling methods from infectious disease modelling with those from information theory optimal design. Outcomes will enable more tailored and effective pandemic response.Read moreRead less
Norovirus Infection At The Stress Granule-PKR-p-elF2α Axis
Funder
National Health and Medical Research Council
Funding Amount
$505,967.00
Summary
This project application will aim to investigate and understand how viruses that cause vomiting and diarrhoea are able to infect, proliferate and spread within the human body. It aims to address how viruses are able to avoid and replicate in the presence of an effective immune response. We have evidence showing that Noroviruses are able to exploit certain antiviral proteins to paradoxically aid in virus replication and survival.
THE EFFECT OF STRESS AND ENVIRONMENTAL ENRICHMENT ON DISEASE PROGRESSION IN MESIAL TEMPORAL LOBE EPILEPSY
Funder
National Health and Medical Research Council
Funding Amount
$578,201.00
Summary
Mesial temporal lobe epilepsy, the most common form of drug-resistant epilepsy in adults, is a progressive neurodegenerative condition for which there is currently no effective disease modifying treatment. This proposal will explore whether co-morbid stress accelerates disease progression in MTLE, and whether targeting stress pathways by medical and environmental manipulations can mitigate against this.
Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitab ....Microanalysis of novel carbon thin films. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. Electrical devices can be fabricated with these films suitable for use in compact electrical devices requiring high current density. This project will add to the techniques used for the analysis of carbon coatings being developed in Australia. Read moreRead less
Single atom defined nanostructures: atom-electronics beyond the miniaturization limit. The emerging era of atom-electronics promises to revolutionise microelectronics in the 21st century by going beyond the conventional miniaturization limit of microelectronics. Emerging atom level fabrication and control techniques offer the promise of building devices whose fundamental components are built atom-by-atom and function under completely new rules. This Discovery Project will apply critical new theo ....Single atom defined nanostructures: atom-electronics beyond the miniaturization limit. The emerging era of atom-electronics promises to revolutionise microelectronics in the 21st century by going beyond the conventional miniaturization limit of microelectronics. Emerging atom level fabrication and control techniques offer the promise of building devices whose fundamental components are built atom-by-atom and function under completely new rules. This Discovery Project will apply critical new theoretical tools, in partnership with leading experimental groups, to enable the exploration of this technology and the creation of new and innovative applications which will have far reaching implications in all areas of society and significant national benefit.Read moreRead less
Braiding Dynamics of Majorana Modes. The project aims to investigate Majorana modes, exotic quantum particles which can be found in the new material class of Topological Superconductivity. In particular, they can be utilised to construct fault-tolerant quantum bits. Quantum logic gates are enabled by moving these Majorana modes around each other, i.e., by braiding them, leading to an error-free quantum performance. This project will deliver cutting-edge simulations to analyse the braiding proces ....Braiding Dynamics of Majorana Modes. The project aims to investigate Majorana modes, exotic quantum particles which can be found in the new material class of Topological Superconductivity. In particular, they can be utilised to construct fault-tolerant quantum bits. Quantum logic gates are enabled by moving these Majorana modes around each other, i.e., by braiding them, leading to an error-free quantum performance. This project will deliver cutting-edge simulations to analyse the braiding process in condensed matter systems and benchmark how these fault-tolerant quantum bits operate under real-world conditions. By providing the theory for advanced structures and devices, this project will inform experiments and pave the way for future technology based on topological phenomena.Read moreRead less
Imaging surface topography using Lloyd's Mirror in photo-emission electron microscopy. The wide-ranging and innovative nature of the proposal will significantly raise Australia's international profile in condensed matter physics through high impact publications and invited presentations at major international conferences. Researchers will be trained in cutting-edge electron microscopy and synchrotron science. A spin-off company will be formed to commercialise software for reconstructing surface ....Imaging surface topography using Lloyd's Mirror in photo-emission electron microscopy. The wide-ranging and innovative nature of the proposal will significantly raise Australia's international profile in condensed matter physics through high impact publications and invited presentations at major international conferences. Researchers will be trained in cutting-edge electron microscopy and synchrotron science. A spin-off company will be formed to commercialise software for reconstructing surface topography and generating movies of dynamic events. The development of new synchrotron based electron microscopy techniques will establish the expertise for the future creation of a dedicated nanotechnology beamline equipped with photo-emission electron microscopy which will have far reaching national benefit in the physical sciences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347797
Funder
Australian Research Council
Funding Amount
$263,000.00
Summary
A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also b ....A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also be used for high-resolution texture analysis and surface reflectivity measurements on numerous types of materials. Thus chemists, geologists, and materials scientists with interests outside of the semiconductor growth community will gain substantial benefit from this instrument for the investigation of materials of technological and economic importance.Read moreRead less
Quantum Dot Self-Assembly via Langmuir Decomposition. We will develop a new capability to precisely position quantum structures on surfaces in large-scale patterns, solving a key problem in nanotechnology. We expect to generate patents governing key lithographic technology which will underpin the fabrication of the next generation of devices and we anticipate the generation of spin-off companies in this area. The ability to integrate new quantum structures into optoelectronics will impact everyd ....Quantum Dot Self-Assembly via Langmuir Decomposition. We will develop a new capability to precisely position quantum structures on surfaces in large-scale patterns, solving a key problem in nanotechnology. We expect to generate patents governing key lithographic technology which will underpin the fabrication of the next generation of devices and we anticipate the generation of spin-off companies in this area. The ability to integrate new quantum structures into optoelectronics will impact everyday life from communications and lighting to environmental sensing and medical care. The project will generate key expertise and high level training for post-doctoral fellows and post-graduate students in materials physics and nanotechnology.Read moreRead less