Benefit Of 2D-strain Surveillance In Improving Cardiovascular Outcomes In Cancer Patients Undergoing Cardiotoxic Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$2,391,979.00
Summary
Cancer survivors are susceptible to heart failure (HF) caused by heart muscle damage from chemotherapy. The current testing for this problem is based on a measure that cannot identify minor changes of cardiac function. Cardiac strain is a sensitive new marker of cardiac function which is predictive of overt dysfunction & HF. This study seeks to identify whether strain can be used to assign treatments that lead to improved cardiac function and are eventually associated with a reduction in HF.
Discovery Early Career Researcher Award - Grant ID: DE240100822
Funder
Australian Research Council
Funding Amount
$383,887.00
Summary
Haloalkaliphilic sulphur oxidising bacteria in dealkalising bauxite residue. This project aims to establish breakthrough technology for neutralising bauxite refinery wastes by creating new knowledge about the taxonomic composition and molecular metabolism of sulphur oxidising bacteria capable of oxidising low-cost element sulphur in extremely haloalkaline niches. The findings will be translated into field feasible ecological engineering technology in partnership with industry partners. This DECR ....Haloalkaliphilic sulphur oxidising bacteria in dealkalising bauxite residue. This project aims to establish breakthrough technology for neutralising bauxite refinery wastes by creating new knowledge about the taxonomic composition and molecular metabolism of sulphur oxidising bacteria capable of oxidising low-cost element sulphur in extremely haloalkaline niches. The findings will be translated into field feasible ecological engineering technology in partnership with industry partners. This DECRA project will also contribute to the net zero waste strategy in Australia and could significantly contribute to global problems of mining waste, carbon emission, and soil depletion if implemented. The commercialisation of the technology package will increase economic advantages and employment in Australia.Read moreRead less
Detection And Management Of Depression In General Practice Patients With Chronic Manifestations Of Ischaemic Heart Disea
Funder
National Health and Medical Research Council
Funding Amount
$499,797.00
Summary
This research will investigate the impact of ischemic heart disease on the prevalence and severity of patients with depression. This will be done via a 12 month general practice based program of 1) systematic screening for depression 2) informing general practitioners of best-practice guidelines for management of depression in these patients, and 3) providing the treating general practitioner with patient-specific, psychiatric advice.
Mid-Career Industry Fellowships - Grant ID: IM230100184
Funder
Australian Research Council
Funding Amount
$1,034,832.00
Summary
A new catchment gully erosion model for a healthier Great Barrier Reef . Sediment impacts Great Barrier Reef water quality and coral health. Erosion of gullies within a river catchment are the dominant source of sediment. This project aims to develop a novel catchment level modelling tool, allowing land managers to compare rehabilitation options and identify optimal actions. The project will generate new knowledge in applied mathematics, using innovative model emulation techniques to bring proce ....A new catchment gully erosion model for a healthier Great Barrier Reef . Sediment impacts Great Barrier Reef water quality and coral health. Erosion of gullies within a river catchment are the dominant source of sediment. This project aims to develop a novel catchment level modelling tool, allowing land managers to compare rehabilitation options and identify optimal actions. The project will generate new knowledge in applied mathematics, using innovative model emulation techniques to bring process insights to the catchment scale. Expected outcomes include a validated land rehabilitation decision making tool, benefiting both natural resource managers by increasing ability to meet Reef 2050 policy targets and landowners though development of Natural Capital Markets.Read moreRead less
Mineral Biosequestration of Organic Carbon in Early Pedogenesis of Tailings. Upcycling tailings into soil (technosols developed from technogenic parent materials) offers a sustainable approach to overcome severe topsoil shortage that limits the progress of ecological rehabilitation of tailings across mine sites. This project aims to establish new knowledge on mineral bioweathering, organic carbon (OC) sequestration in rapidly formed mineral phases, and OC turnover driven by colonising microbes a ....Mineral Biosequestration of Organic Carbon in Early Pedogenesis of Tailings. Upcycling tailings into soil (technosols developed from technogenic parent materials) offers a sustainable approach to overcome severe topsoil shortage that limits the progress of ecological rehabilitation of tailings across mine sites. This project aims to establish new knowledge on mineral bioweathering, organic carbon (OC) sequestration in rapidly formed mineral phases, and OC turnover driven by colonising microbes and plant roots, in the early pedogenesis of tailings initiated by inputs of organic and inorganic materials. This new knowledge is required for developing eco-engineering technology adaptable to a wide range of tailings of diverse mineralogy, to achieve sustainable tailings rehabilitation and organic carbon sequestration.Read moreRead less
Repurposing urban construction waste to create diverse wildflower meadows. Wildflower meadows have been planted extensively in European cities for aesthetic and biodiversity benefits. In SE Australia, they are stunning, but rare, features of critically endangered grassy woodlands because most native wildflowers cannot cope with intense grazing and high soil nutrients associated with agriculture. This project aims to develop a novel process for establishing native wildflower meadows in urban park ....Repurposing urban construction waste to create diverse wildflower meadows. Wildflower meadows have been planted extensively in European cities for aesthetic and biodiversity benefits. In SE Australia, they are stunning, but rare, features of critically endangered grassy woodlands because most native wildflowers cannot cope with intense grazing and high soil nutrients associated with agriculture. This project aims to develop a novel process for establishing native wildflower meadows in urban parks and degraded grassy woodlands by repurposing low nutrient mineral waste from the construction industry. It will have multiple benefits including restoring urban biodiversity, increasing people's mental well-being, developing new markets for recycled construction waste and reducing the amount of waste going to landfill. Read moreRead less
I-HEART - Implementation Of HEArt Failure Guidelines In Regional AusTralia
Funder
National Health and Medical Research Council
Funding Amount
$1,266,173.00
Summary
Heart failure (HF) is a common disease of the heart with a high rehospitalisation and mortality rate. Regional HF patients rarely receive the full benefits of evidence-based care simply due to inaccessibility to a HF specialist team. This translational project will implement key recommendations from clinical guidelines in regional health services and improve access to specialist services. It has the potential to keep patients out of hospital and save lives.
Integration Of Risk Evaluation In Cardiovascular Disease Management Programs.
Funder
National Health and Medical Research Council
Funding Amount
$5,162,176.00
Summary
This study will determine the feasibility of a coordinated health care team approach to the treatment of cardiovascular disorders. It will examine a range of issues – who would most benefit from this approach, its value for money, the relative importance of health care services to consumers, and where to invest additional health funds. Built on strong collaborations between expert researchers in advanced diagnostic techniques, coordinated health care, community health care and health economics, ....This study will determine the feasibility of a coordinated health care team approach to the treatment of cardiovascular disorders. It will examine a range of issues – who would most benefit from this approach, its value for money, the relative importance of health care services to consumers, and where to invest additional health funds. Built on strong collaborations between expert researchers in advanced diagnostic techniques, coordinated health care, community health care and health economics, this provides a unique opportunity to benefit millions of Australians.Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Multi-service assessment of intertidal treatment wetlands. This project aims to investigate the use of constructed intertidal wetlands to reduce nitrogen pollution while providing co-benefits including carbon sequestration and biodiversity. This research will generate a holistic assessment of the services, disservices, and cost-effectiveness of intertidal treatment wetlands compared to traditional wastewater treatment approaches. Expected outcomes include a full-scale multi-disciplinary environm ....Multi-service assessment of intertidal treatment wetlands. This project aims to investigate the use of constructed intertidal wetlands to reduce nitrogen pollution while providing co-benefits including carbon sequestration and biodiversity. This research will generate a holistic assessment of the services, disservices, and cost-effectiveness of intertidal treatment wetlands compared to traditional wastewater treatment approaches. Expected outcomes include a full-scale multi-disciplinary environmental and economic assessment of a constructed treatment wetland in a new urban development, providing industry and government partners the knowledge required to broaden uptake of intertidal wetlands as a cost-effective solution to growing levels of coastal anthropogenic pollution.Read moreRead less