Developing Personalised Treatment For Retinal Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$262,220.00
Summary
Dr Chen seeks a clinical CDF1 to support his ambition in combining his expertise in clinical management of retinal diseases with a growing track record of clinical trials and laboratory science to develop treatment for retinal degeneration. This is achieved through a patient-centred translational platform that he has established. In the next 5 years, He will identify the most suitable method for measuring progression and develop personalised therapy for a phase I clinical trial.
Structural And Drug Discovery Studies Of Medically Important Protein Complexes
Funder
National Health and Medical Research Council
Funding Amount
$438,577.00
Summary
My research is focused on structural studies of medically important biological systems, where specific protein complex formation contributes to human illnesses. I use X-ray crystallography to visualize the whole complex at atomic resolution as well as to determine whether binding partners have undergone changes in shape upon complex formation. This structural information then helps me in drug design with goals to either disrupt or modulate the complex.
Understanding Allosteric Modulation And Biased Signalling At Family B GPCRs
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Family B GPCRs are therapeutic targets for drugs treating osteoporosis, hypercalcaemia, Paget’s disease, type II diabetes and are being actively pursued for other diseases that represent major global health burdens. Despite huge financial input, there are no orally available drugs that act on these receptors. This speaks to a lack of mechanistic understanding of how they work. My research focuses on addressing this question and how to exploit these receptors to design and identify better drugs.
Assembly Of Mitochondrial Respiratory Chain Complexes And Their Defects Associated With Disease.
Funder
National Health and Medical Research Council
Funding Amount
$413,431.00
Summary
Mitochondrial “respiratory chain complexes are multi-subunit assemblies that function to produce most of our cellular energy. Defects in the assembly of these complexes can result in mitochondrial disease, including infant death. The assembly of the respiratory complexes is a complicated procedure and the mechanisms involved in disease remain elusive. This work will aid in our understanding of how these protein complexes are built and how defects in their assembly can cause disease.
Structural And Mechanical Determinants Of Airway Hyperresponsiveness
Funder
National Health and Medical Research Council
Funding Amount
$415,219.00
Summary
In asthma and chronic obstructive pulmonary disease, the capacity for airway passages to narrow is increased which limits airflow in and out of the lung and contributes to disease severity. The aim of this project is to identify the underlying physiological abnormalities producing the increased narrowing capacity. The investigations will focus on the role of the airway smooth muscle and epithelial layers that are widely implicated in driving the increased narrowing response, but for which the ev ....In asthma and chronic obstructive pulmonary disease, the capacity for airway passages to narrow is increased which limits airflow in and out of the lung and contributes to disease severity. The aim of this project is to identify the underlying physiological abnormalities producing the increased narrowing capacity. The investigations will focus on the role of the airway smooth muscle and epithelial layers that are widely implicated in driving the increased narrowing response, but for which the evidence remains circumstantial.Read moreRead less