Preconception Predictors Of Health, Behaviour And Emotional Adjustment At Seven Years
Funder
National Health and Medical Research Council
Funding Amount
$1,170,830.00
Summary
An understanding of the importance of a healthy start to life has underpinned major health policies including Australia’s National Agenda for Early Childhood. The capacity of parents to provide that healthy start has received little study. The present project investigates the extent to which parental lifestyle, social and emotional adjustment prior to conception predictor emotional problems, disruptive behaviour and health in their children at seven years.
The Women’s Wellness After Cancer Program: A National Multisite Randomised Clinical Trial Of An E-Health Enabled Lifestyle Modification Intervention To Improve The Health And Wellness Of Women After Cancer Treatment
Funder
National Health and Medical Research Council
Funding Amount
$1,209,031.00
Summary
Advances in diagnostics, treatment and clinical practice have transformed some cancers from fatal to chronic and sometimes curable diseases. Many Australian women now live with the effects of cancer treatment and are at risk of cancer recurrence, chronic disease and poor quality of life. The Womens Wellness After Cancer Program aims to maximise the wellbeing of women treated for cancer, utilising internet and Smartphone technology to support them to live healthier lifestyles.
Substance abuse is a significant social and economic burden upon Australian societies and on societies around the world. Treatment remains problematic due to the multi-layer nature of the disease, difficulties with treatment compliance and less than ideal treatment regimes. The present study aims to improve treatments for alcohol and drug abuse using pre-clinical models to identify and characterize a new brain system implicated in drug-seeking.
Enhancing And Integrating Addiction Neuroscience Knowledge With Clinical Practice, By Transforming The Approach To Assessment And Classification Protocols, And Improving Outcomes By Using Neurocognitive Phenotypes For Tailored Treatments
Funder
National Health and Medical Research Council
Funding Amount
$838,845.00
Summary
Brain research has reshaped the way we understand addiction, but has not yet led to more effective treatments. This Fellowship will facilitate the creation of a neuroscience- and technology-inspired research clinic that will conduct world-leading research into the fundamental underpinnings of how lifestyle and psychological interventions affect brain and mental health, as well as translate this knowledge into effective, safe and accessible treatments tailored to those affected by addiction.
Modelling Of Clinic And Ambulatory Blood Pressure On Cardiovascular Risk And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$133,957.00
Summary
Whilst ambulatory blood pressure monitoring data has been shown to be a good predictor of cardiovascular events, there remains controversy as to its utility in clinical practice. This project will use data from existing population and clinical cohort studies to examine the role of ambulatory blood pressure in risk assessment and hypertension management in Australia and around the globe. The findings are likely to have a major impact on clinical guidelines for hypertension management.
Young Onset Colorectal Cancer: Genetics Pathology And Environment
Funder
National Health and Medical Research Council
Funding Amount
$439,180.00
Summary
There has been a steady increase since 2002, in the age-standardised incidence of CRC in males under 45 years in Australia, contrasting with the stabilisation in incidence of CRC in males of age 45 years and over. Persons under 50 years are not routinely screened unless they have a significant family history of CRC. Young-onset rectal cancer is associated with late presentations and with a higher mortality. This proposal will address the possible risk factors for young-onset CRC.
An inability to resist a temptation or repeated failures of self-regulation can lead to 'impulsive' and 'compulsive' behaviours that relate to a host of personal and social problems (eg., excessive eating, gambling, and substance use). Despite this, very little research has studied the neural and psychological underpinnings of these behaviours. My research will take advantage of recent innovations and approaches to fill this void and have implications for diagnosis and treatment.
Exploring The Meaning And Experience Of Cardiovascular Health Of People Who Live With Severe And Persistent Mental Illness.
Funder
National Health and Medical Research Council
Funding Amount
$89,114.00
Summary
People with serious mental illness die up to 25 years before their peers, mostly from cardiovascular disease. Despite extensive research, we have made little impact on addressing this health inequity. By exploring the experience and meaning of personal cardiovascular health to people with severe mental illness, this study aims to generate new knowledge that will inform the tailoring of cardiovascular health promotion interventions that meet the unique requirements of this vulnerable population.
New High-risk Variants For Colorectal Cancer: The Post-GWAS Era
Funder
National Health and Medical Research Council
Funding Amount
$710,105.00
Summary
Our aim is to discover new genes that greatly increase bowel cancer risk. If we can identify these carriers we may be able to prevent them getting cancer. By studying DNA related to bowel cancer, using a novel family design, we will identify families most likely to carry the new genes. We will focus genetic testing, using new techniques, to look for mutations in these prioritised families. Identified mutations will be tested in a 3,500 bowel cancer cases to see how important they are.