Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Understanding The Role Of RAS Mutations In Thyroid Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$463,854.00
Summary
My fellowship will examine the association of RAS mutations in thyroid cancer. RAS proteins are the most mutated in cancer and I will investigate how they work in thyroid cancer. RAS mutated thyroid cancer is more likely to cause death. This grant will be based in the pioneering lab of Prof Fagin at Memorial Sloan Kettering Cancer Center and the Garvan Institute of Medical Research. It is hoped by understanding these mutations, new treatments for thyroid cancer can be developed.
Stabilisation of erodible and dispersive soils with natural wood processing by-products. Lignosulfonate is a by-product of paper and wood processing industry, which is an environmentally friendly organic compound with an immense potential for stabilising erodible and dispersive soils when mixed in small quantities. This project will deliver practical design guidelines and specifications for sustainable performance of road and rail embankments that are treated with lignosulfonates. Utilisation of ....Stabilisation of erodible and dispersive soils with natural wood processing by-products. Lignosulfonate is a by-product of paper and wood processing industry, which is an environmentally friendly organic compound with an immense potential for stabilising erodible and dispersive soils when mixed in small quantities. This project will deliver practical design guidelines and specifications for sustainable performance of road and rail embankments that are treated with lignosulfonates. Utilisation of lignosulfonates in soil stabilisation is not only cost-effective, but also has the benefit of eliminating a waste disposal problem. The proposed project will improve industrial competitiveness and Australia's export earnings through increased commercialisation and technology transfer in the region.Read moreRead less
Theoretically derived calibration of the neutron moisture meter. The moisture content of soils is of key importance in a wide range of situations including agriculture, engineering and land and water management. The measurement of soil moisture contents in the field is problematic, and even commonly used methods like the neutron probe give results of limited accuracy. This research will enable calibration curves for the neutron probe to be determined theoretically, thereby improving the accuracy ....Theoretically derived calibration of the neutron moisture meter. The moisture content of soils is of key importance in a wide range of situations including agriculture, engineering and land and water management. The measurement of soil moisture contents in the field is problematic, and even commonly used methods like the neutron probe give results of limited accuracy. This research will enable calibration curves for the neutron probe to be determined theoretically, thereby improving the accuracy of moisture content measurements and enhancing its usefulness to industry and research.Read moreRead less
Coal-ash as a resource for sustainable soil-management in plant production systems. Acidification and salinisation are major causes of land degradation in Australia, costing $1-2 billion to combat. Farmers used 1.9M t of lime and 1.0M t of gypsum to manage their soils in 2000. Power stations annually produce 12M t of coal-ash that have functional characteristics of lime and gypsum and can potentially ameliorate degraded land. Presently only 43% of the ash is used and almost entirely for constr ....Coal-ash as a resource for sustainable soil-management in plant production systems. Acidification and salinisation are major causes of land degradation in Australia, costing $1-2 billion to combat. Farmers used 1.9M t of lime and 1.0M t of gypsum to manage their soils in 2000. Power stations annually produce 12M t of coal-ash that have functional characteristics of lime and gypsum and can potentially ameliorate degraded land. Presently only 43% of the ash is used and almost entirely for construction with the rest going into landfills. This project will determine the sustainable use of coal-ash to improve structure and nutritive properties of the soil and to raise crop yield across several sites in Australia.Read moreRead less
Reducing export of acid sulfate soil products (particularly iron, aluminium, phosphorus, and organic carbon) as contaminants to coastal waters. Current Australian management of acid sulfate soils (ASS) emphasises the reduction of acidity in floodplain drainage. However this acidity is mainly from the dissolved metals, which can be increased by some management techniques. Dissolved metals can be biotoxic or encourage harmful coastal phytoplankton. Organic metal complexes can increase metal tran ....Reducing export of acid sulfate soil products (particularly iron, aluminium, phosphorus, and organic carbon) as contaminants to coastal waters. Current Australian management of acid sulfate soils (ASS) emphasises the reduction of acidity in floodplain drainage. However this acidity is mainly from the dissolved metals, which can be increased by some management techniques. Dissolved metals can be biotoxic or encourage harmful coastal phytoplankton. Organic metal complexes can increase metal transport but shading of soil and drain surfaces, and constructed wetlands offers a new management tool. Our research aims to reduce transport to coastal waters of these ASS products. A sustainable Australian coast requires that improvement of ASS floodplains must not be at the environmental expense of coastal waters. Read moreRead less
How do soils grow? Modelling soil development in the landscape. This project addresses the fundamental environmental issue of land degradation in Australia. The environment is both sensitive and diverse with uses from intensive agriculture, grazing, to large scale industrial. This project will build a model that will enable us to understand how soil forms and landscape evolves with time, to reconstruct the history of soil. The model will allow us to make the Australian populous aware of the frag ....How do soils grow? Modelling soil development in the landscape. This project addresses the fundamental environmental issue of land degradation in Australia. The environment is both sensitive and diverse with uses from intensive agriculture, grazing, to large scale industrial. This project will build a model that will enable us to understand how soil forms and landscape evolves with time, to reconstruct the history of soil. The model will allow us to make the Australian populous aware of the fragility of soil formation. This will lead to greater social awareness of our precarious position on the Australian landscape.Read moreRead less
Optimised field delineation of contaminated soils. This project seeks to cost-efficiently identify the contaminated areas of a soil site which will require remediation. There are many thousands of sites contaminated with metals and/or organics across urban and rural Australia and some tens of millions across the world. These sites pose a serious potential threat to human health. Detection (and remediation) of such sites is expensive. The project aims to deliver a cheaper method of detection thro ....Optimised field delineation of contaminated soils. This project seeks to cost-efficiently identify the contaminated areas of a soil site which will require remediation. There are many thousands of sites contaminated with metals and/or organics across urban and rural Australia and some tens of millions across the world. These sites pose a serious potential threat to human health. Detection (and remediation) of such sites is expensive. The project aims to deliver a cheaper method of detection through a novel combination of infra-red and X-ray spectroscopies combined with data-fused soil inference and optimised directed sampling and mapping. This is intended to reduce the economic barrier to detection and remediation, considerably hastening the removal of this health risk. Resulting novel technology could be transferred and commercialised internationally.Read moreRead less
Stabilization of hydrology at waste disposal sites through revegetation. Persistent drought in the past 20 years has increased the extraction of groundwater reserves by more than 2-fold to meet domestic water requirements throughout Australia. This water resource could be threatened from poorly managed waste disposal sites, where removal of pre-existing vegetation often exacerbates adverse hydrological processes of deep drainage. This study will provide information for the waste management indus ....Stabilization of hydrology at waste disposal sites through revegetation. Persistent drought in the past 20 years has increased the extraction of groundwater reserves by more than 2-fold to meet domestic water requirements throughout Australia. This water resource could be threatened from poorly managed waste disposal sites, where removal of pre-existing vegetation often exacerbates adverse hydrological processes of deep drainage. This study will provide information for the waste management industry that has achieved an annual turnover of more than $200 million in recent years. It will present recommendations on how vegetation can be employed to meet regulatory requirements by the industry.Read moreRead less
Chicken Litter Char for Soil Health and Carbon Sequestration. The project has considerable national benefit from a range of perspectives. The recycling of waste residues from farming to the rejuvenation the carbon in soil, through the application of chars, will promote sustainable land use and increase agricultural productivity. Further, an improved understanding of the mechanisms by which chars sequester carbon and nitrogen compounds will assist in the adaptation of Australian agriculture to th ....Chicken Litter Char for Soil Health and Carbon Sequestration. The project has considerable national benefit from a range of perspectives. The recycling of waste residues from farming to the rejuvenation the carbon in soil, through the application of chars, will promote sustainable land use and increase agricultural productivity. Further, an improved understanding of the mechanisms by which chars sequester carbon and nitrogen compounds will assist in the adaptation of Australian agriculture to the impact of climate change. Pyrolysis technology, in char generation, has the potential for primary producers to turn waste products into something of value, which may provide their businesses with an additional income stream.Read moreRead less