Host-tumour interplay in Tasmanian devils with devil facial tumour disease: can immune cells be harnessed for therapy? Tasmanian devils only exist naturally in Tasmania and Devil Facial Tumour Disease, an infectious cancer, could cause the extinction of the Tasmanian devil. This project will determine if Devil Facial Tumour Disease reduces the effectiveness of the devil's immune system and test if activated immune cells can protect against this disease.
Natural selection and the Tasmanian devil. This project aims to explain evolution of immune capabilities in response to disease threats in the wild by assessing the immune adaptive capabilities of Tasmanian devils in response to facial tumour disease. It plans to determine how the expression of immune genes differs between wild and captive populations. The project will combine immunology, epidemiology and evolutionary biology, to understand the role of host genetic and phenotypic adaptations to ....Natural selection and the Tasmanian devil. This project aims to explain evolution of immune capabilities in response to disease threats in the wild by assessing the immune adaptive capabilities of Tasmanian devils in response to facial tumour disease. It plans to determine how the expression of immune genes differs between wild and captive populations. The project will combine immunology, epidemiology and evolutionary biology, to understand the role of host genetic and phenotypic adaptations to disease threats. The project will assist in the development of diagnostic tools for managing this and other threatened species and for screening disease resistance markers across wild and captive insurance populations.Read moreRead less
Female multiple mating and the evolutionary origins of complex societies. This project plans to connect micro-evolutionary processes with macro-evolutionary change to provide a unified understanding of why animals live together. Evolutionary transitions to and from complex social behaviour appear linked to female multiple mating (polyandry). However, the causal pathway by which variation in polyandry results in the emergence and diversification of sociality is yet to be established. Using a vert ....Female multiple mating and the evolutionary origins of complex societies. This project plans to connect micro-evolutionary processes with macro-evolutionary change to provide a unified understanding of why animals live together. Evolutionary transitions to and from complex social behaviour appear linked to female multiple mating (polyandry). However, the causal pathway by which variation in polyandry results in the emergence and diversification of sociality is yet to be established. Using a vertebrate system we aim to integrate empirical, theoretical and comparative approaches to show: the ecological causes of individual variation in female polyandry; its effect on social behaviours that promote social complexity at the population level; and how this corresponds to divergence in social complexity across species.Read moreRead less
Immunisation to protect against transmissible cancers in Tasmanian devils. This project aims to identify the immune escape mechanisms that the transmissible cancers, Devil Facial Tumour Disease (DFTD) use to avoid being killed by the immune system. Since the discovery of the second transmissible cancer (DFT2) mystery surrounds whether the devils immune system can respond to this cancer, hence this project will investigate the immune response to DFT2. The final aims are to develop a vaccine with ....Immunisation to protect against transmissible cancers in Tasmanian devils. This project aims to identify the immune escape mechanisms that the transmissible cancers, Devil Facial Tumour Disease (DFTD) use to avoid being killed by the immune system. Since the discovery of the second transmissible cancer (DFT2) mystery surrounds whether the devils immune system can respond to this cancer, hence this project will investigate the immune response to DFT2. The final aims are to develop a vaccine with the potential to protect healthy devils and cure devils with DFTD.Read moreRead less
Using guardian dogs to protect threatened species. This project explores whether guardian dogs can be used to reduce predation on threatened native wildlife. Guardian dogs are ancient breeds of dogs that live with livestock and protect them from wild predators. The project aims to measure the impacts of guardian dogs on distribution and behaviour of feral cats and red foxes, and monitor trial reintroductions of eastern barred bandicoots in the presence of guardian dogs. It aims to provide an inn ....Using guardian dogs to protect threatened species. This project explores whether guardian dogs can be used to reduce predation on threatened native wildlife. Guardian dogs are ancient breeds of dogs that live with livestock and protect them from wild predators. The project aims to measure the impacts of guardian dogs on distribution and behaviour of feral cats and red foxes, and monitor trial reintroductions of eastern barred bandicoots in the presence of guardian dogs. It aims to provide an innovative solution to one of Australia's most significant conservation problems: the persistent failure of attempts to reintroduce threatened species to open landscapes with invasive predators.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100118
Funder
Australian Research Council
Funding Amount
$159,450.00
Summary
Sensor calibration facility for spectral and thermal remote sensing. This project aims to establish a calibration facility for the radiometric and spectral correction of hyperspectral and thermal sensors for ultrahigh-resolution remote sensing. Sensor calibration and characterisation is critical to the accuracy of hyperspectral and thermal data products, however, there is no central facility in Australia for this purpose. This project will provide significant benefits, such as growing our capaci ....Sensor calibration facility for spectral and thermal remote sensing. This project aims to establish a calibration facility for the radiometric and spectral correction of hyperspectral and thermal sensors for ultrahigh-resolution remote sensing. Sensor calibration and characterisation is critical to the accuracy of hyperspectral and thermal data products, however, there is no central facility in Australia for this purpose. This project will provide significant benefits, such as growing our capacity in ultrahigh-resolution remote sensing for ecosystem science, biosecurity, and disaster response.Read moreRead less
Developing a wildlife health intelligence and vaccine distribution system. This project aims to establish an industry-linked pipeline for vaccines to be delivered to animals in edible baits and a near real-time monitoring system for assessing the impact of management actions. This project will develop ultrasensitive diagnostic tests and incorporate biomarkers into baits from Australia's leading pest animal control company. Bait uptake and disease status in the field will be monitored using artif ....Developing a wildlife health intelligence and vaccine distribution system. This project aims to establish an industry-linked pipeline for vaccines to be delivered to animals in edible baits and a near real-time monitoring system for assessing the impact of management actions. This project will develop ultrasensitive diagnostic tests and incorporate biomarkers into baits from Australia's leading pest animal control company. Bait uptake and disease status in the field will be monitored using artificial intelligence technology developed in Tasmania. This integrated wildlife health intelligence and scalable vaccine platform can help protect the iconic Tasmanian devil from disease and increase Australia's preparedness for looming threats to the livestock industry such as African swine fever.Read moreRead less
The role of leaf veins in vascular plant evolution. Leaves are continuously irrigated by a system of internal plumbing that defines their maximum photosynthetic output, and angiosperms are the most productive plants on earth largely by virtue of a uniquely efficient system of leaf plumbing. This project will identify how such an important modification of leaf water transport came to evolve.
ARC Centre of Excellence for Australian Biodiversity and Heritage. The ARC Centre of Excellence of Australian Biodiversity and Heritage will create a world-class interdisciplinary research programme to understand Australia’s unique biodiversity and heritage. The Centre will track the changes to Australia’s environment to examine the processes responsible for the changes and the lessons that can be used to continue to adapt to Australia’s changing environment. The Centre will support connection ....ARC Centre of Excellence for Australian Biodiversity and Heritage. The ARC Centre of Excellence of Australian Biodiversity and Heritage will create a world-class interdisciplinary research programme to understand Australia’s unique biodiversity and heritage. The Centre will track the changes to Australia’s environment to examine the processes responsible for the changes and the lessons that can be used to continue to adapt to Australia’s changing environment. The Centre will support connections between the sciences and humanities and train future generations of researchers to deal with future global challenges and inform policy in an interdisciplinary context. Read moreRead less
Restoring resilience in wildlife populations. This project will be the first to develop landscape models of habitat quality for wildlife that are based on a mechanistic, animal-centric approach to quantifying habitat. This will be an important step in understanding the habitat elements that wildlife need to live in altered landscapes, with implications central to restoration and revegetation.