Chip liquid chromatography-inductively coupled plasma-mass spectrometry: a new hyphenated microfluidic instrument for metallomics. An alliance of two Australian universities and a world-leading scientific instrument company will develop innovative technology that will enable new reliable, sensitive and patient-specific medical tests, as well as being used to probe causes of significant diseases that appear to involve trace levels of metals in the body.
Integrating Economic Valuation and Water Quality Modelling for Improving Management of Coastal Catchments. This project will apply and integrate water quality models and economic assessment techniques to assist policy makers and catchment managers balance competing development pressures and environmental concerns in coastal catchments. The research is fundamental to underpinning the sustainable management of coastal catchments which provide major economic, environmental and community benefits. T ....Integrating Economic Valuation and Water Quality Modelling for Improving Management of Coastal Catchments. This project will apply and integrate water quality models and economic assessment techniques to assist policy makers and catchment managers balance competing development pressures and environmental concerns in coastal catchments. The research is fundamental to underpinning the sustainable management of coastal catchments which provide major economic, environmental and community benefits. The project will provide robust tools to predict water quality impacts under a range of conditions and it will develop techniques for the economic valuation of market and non-market impacts. The project will demonstrate the integration of water quality and economic modelling and how it can influence policy and investment in conservation and remediation.Read moreRead less
Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for l ....Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for liposomes. This provides a significant PhD training opportunity and brings an international focus to the development of planar patch-clamp electrophysiology in Australia. The project has significant commercial potential by developing both the planar patch-clamp electrophysiology techniques for liposomes and producing a novel biomimetic mechanosensitive biosensor.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100060
Funder
Australian Research Council
Funding Amount
$638,853.00
Summary
High speed multi modal in-situ Transmission Electron Microscopy platform. This project aims to establish an in situ transmission electron microscope that will allow the atomic scale imaging of materials, while simultaneously measuring physical, chemical, electrical and optical properties, using a novel combination of cutting edge in-situ sample holders and an instrument mounted laser system. The instrument will be optimised for imaging of dynamic phenomena and the combination of spatial resoluti ....High speed multi modal in-situ Transmission Electron Microscopy platform. This project aims to establish an in situ transmission electron microscope that will allow the atomic scale imaging of materials, while simultaneously measuring physical, chemical, electrical and optical properties, using a novel combination of cutting edge in-situ sample holders and an instrument mounted laser system. The instrument will be optimised for imaging of dynamic phenomena and the combination of spatial resolution in the picometre scale, with microsecond level temporal resolution will be unique. The instrument will accelerate research into hydrogen production and carbon dioxide transformation, and thus support Australia's move to a more sustainable economy. Read moreRead less
Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100229
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A prototype Scanning Helium Atom Microscope (SHeM) for soft materials. The scanning helium atom microscope (SHeM) has been a tantalising prospect since the birth of quantum physics. The SHeM would have unparalleled resolution and would be completely non-damaging; potentially revolutionising the imaging of soft delicate materials. This project will develop the first SHeM instrument in Australia to study soft matter.
Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team ....Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team recently invented the scanning helium atom microscope (SHeM), which can image surfaces non-destructively with nanoscale resolution. They will use the SHeM to determine the new fundamental physics that underpins the imaging mechanism. Outcomes include turning SHeM into a tool that materials and biological scientists can use in laboratories worldwide.Read moreRead less
Integrity prediction of ground precision surfaces. This project aims to establish a new approach to enable a reliable and accurate prediction of precision surface grinding. Precision grinding is often the final step in the manufacturing chains for a broad range of metal, ceramic, optical glass and semiconductor components, which must have ultra-high surface integrity and accurate dimensions. To date, the surface integrity of a ground component cannot be predicted due to the involvement of many r ....Integrity prediction of ground precision surfaces. This project aims to establish a new approach to enable a reliable and accurate prediction of precision surface grinding. Precision grinding is often the final step in the manufacturing chains for a broad range of metal, ceramic, optical glass and semiconductor components, which must have ultra-high surface integrity and accurate dimensions. To date, the surface integrity of a ground component cannot be predicted due to the involvement of many random factors and variables in a precision surface grinding process, resulting in high failure rates and processes requiring repeated surface measurements. The novel approach for surface integrity prediction developed by this project will make a vital step forward in advancing the discipline of precision surfacing, establish a new knowledge base and bring about significant technological impacts to the manufacturing industry.Read moreRead less
A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using ....A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using optically excited piezo-resistive sensors, and cold femtosecond laser ablation of hard dental tissue. Expected outcomes include a working prototype for laser removal of tooth materials at speeds exceeding dental drills, providing benefits in miniaturized laser devices and ultimately removing pain from dental procedures. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100121
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Three-dimensional super-resolution nanophotonic fabrication facility. This stimulated emission depletion microscopy nanophotonic fabrication facility will be the first nanophotonic fabrication facility that is able to achieve optical resolution far beyond the diffraction limit, which will facilitate breakthroughs in cutting-edge nanotechnology research areas.