Chip liquid chromatography-inductively coupled plasma-mass spectrometry: a new hyphenated microfluidic instrument for metallomics. An alliance of two Australian universities and a world-leading scientific instrument company will develop innovative technology that will enable new reliable, sensitive and patient-specific medical tests, as well as being used to probe causes of significant diseases that appear to involve trace levels of metals in the body.
New separation technologies for profiling metabolites in biological samples. Metabolomics is an important new field of science that is contributing to the understanding of life processes at the molecular level. But a widely acknowledged major limitation of current metabolomics technologies is the inability to accurately identify high numbers of detected metabolites in the biological extracts being studied. This project will develop cutting-edge separation science approaches to address this exist ....New separation technologies for profiling metabolites in biological samples. Metabolomics is an important new field of science that is contributing to the understanding of life processes at the molecular level. But a widely acknowledged major limitation of current metabolomics technologies is the inability to accurately identify high numbers of detected metabolites in the biological extracts being studied. This project will develop cutting-edge separation science approaches to address this existing problem in metabolomics analysis. In doing so it will provide enormous benefit to Australian biotechnology and biomedical research and play a major role in transferring capabilities to laboratories and research institutes that are involved in research aimed at elucidating biological pathways and networks.Read moreRead less
Managing endangered Banteng in a jointly-managed national park: contested values, Indigenous aspirations and resource use. Should north Australia's huge populations of feral animals be eradicated for conservation, or exploited as a rare opportunity for Aboriginal enterprise in remote regions? We examine options for a herd of Banteng, a cattle species endangered in its native Asian range but abundant in Gurig Ganak Barlu National Park, Aboriginal land managed jointly by traditional owners and a c ....Managing endangered Banteng in a jointly-managed national park: contested values, Indigenous aspirations and resource use. Should north Australia's huge populations of feral animals be eradicated for conservation, or exploited as a rare opportunity for Aboriginal enterprise in remote regions? We examine options for a herd of Banteng, a cattle species endangered in its native Asian range but abundant in Gurig Ganak Barlu National Park, Aboriginal land managed jointly by traditional owners and a conservation agency. In this unique cross-disciplinary study Aboriginal and non-Aboriginal stakeholders will identify Park values that may be threatened by Banteng. Those values will be incorporated in decision-support tools (bio-economic models) identifying tradeoffs between protecting values and providing incomes for Indigenous landowners.Read moreRead less
Radio Interferometer Studies of Compact Astronomical Sources. The giant black holes in the centres of distant galaxies that are the topic of this study are used to set the reference frame for geodesy on the earth. Remote and exotic as they are, they have real-world applications such as improving the positions available from GPS receivers and measuring continental drift. The signal processing equipment being developed for this new telescope is based on FPGA (field programmable gate array) chips ....Radio Interferometer Studies of Compact Astronomical Sources. The giant black holes in the centres of distant galaxies that are the topic of this study are used to set the reference frame for geodesy on the earth. Remote and exotic as they are, they have real-world applications such as improving the positions available from GPS receivers and measuring continental drift. The signal processing equipment being developed for this new telescope is based on FPGA (field programmable gate array) chips, that promise to revolutionize the data processing industry, from radar to cellular telephones to computer networks. The young scientists who are working on this project will go on to lead the commercial and industrial applications of this new technology.Read moreRead less
Novel approach to study mechanisms of Na+ transport in plants using Lab on a Chip technology. A Lab on a Chip for sodium ion measurements in plants is proposed, offering a long overdue solution to the lack of appropriate techniques to study the mechanisms of sodium iron uptake, transport and compartmentation. Sodium ion transport is a key determinant of salt tolerance, but a good understanding of its transport mechanisms is lacking since no appropriate measurement tools are available. Using the ....Novel approach to study mechanisms of Na+ transport in plants using Lab on a Chip technology. A Lab on a Chip for sodium ion measurements in plants is proposed, offering a long overdue solution to the lack of appropriate techniques to study the mechanisms of sodium iron uptake, transport and compartmentation. Sodium ion transport is a key determinant of salt tolerance, but a good understanding of its transport mechanisms is lacking since no appropriate measurement tools are available. Using the system proposed here, sodium ion is separated from interfering ions, allowing fast and selective measurements. A series of ground breaking studies towards sodium ion uptake, transport and compartmentation in plants will be conducted using this Lab on a Chip.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560868
Funder
Australian Research Council
Funding Amount
$552,475.00
Summary
SHRIMP SI - Microscale stable-isotope analysis in the Earth Sciences. Stable-isotope variations of elements such as oxygen, carbon, and sulphur, preserve the most profound records of environmental conditions during the geological, biological, and climatic evolution of Earth and planets. We will build a stable isotope ion microprobe (SHRIMP SI) to examine extraterrestrial and terrestrial systems in unprecedented detail. In terrestrial applications, the main issue is accuracy at the 0.01 percent ....SHRIMP SI - Microscale stable-isotope analysis in the Earth Sciences. Stable-isotope variations of elements such as oxygen, carbon, and sulphur, preserve the most profound records of environmental conditions during the geological, biological, and climatic evolution of Earth and planets. We will build a stable isotope ion microprobe (SHRIMP SI) to examine extraterrestrial and terrestrial systems in unprecedented detail. In terrestrial applications, the main issue is accuracy at the 0.01 percent level for 20-micron spots, which we can apply to studies of development of life on Earth, climatic records, weathering, and formation of ore bodies. Sample return missions of solar wind and comets will provide unique samples related to the formation of our solar system.Read moreRead less
Non-discriminatory, universal and sensitive detection technologies for fluid based separation techniques in the pharmaceutical industry. The proposed research is focused on the specific needs of Australian and global pharmaceutical industries, and addresses a problem which is becoming increasingly significant with new classes of pharmaceuticals. Successful achievement of the goals of the project will result in major savings of cost and time during drug development and will lead to the productio ....Non-discriminatory, universal and sensitive detection technologies for fluid based separation techniques in the pharmaceutical industry. The proposed research is focused on the specific needs of Australian and global pharmaceutical industries, and addresses a problem which is becoming increasingly significant with new classes of pharmaceuticals. Successful achievement of the goals of the project will result in major savings of cost and time during drug development and will lead to the production of safer drugs. The project will expand collaboration between Australia researchers and the world's largest pharmaceutical company. Specialised training will be provided to both postdoctoral and postgraduate researchers, positioning them to make strong contributions to Australia's growing pharmaceutical industry.Read moreRead less
Disposable microdevices for fast ion analysis. The design and fabrication of a microdevice for ion chromatography will introduce Australia to the field of miniaturised total analytical systems (µTAS). The availability of infrastructure, technology and experience in the µTAS area will provide the foundation for specialised commercialisation of sophisticated, chip-based analytical instruments. These instruments have important applications in forensic, clinical and environmental chemistry.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775760
Funder
Australian Research Council
Funding Amount
$101,967.00
Summary
Satellite remote sensing and GIS data processing facilities at Charles Darwin University, Darwin. Northern Australia is vast, remote and spreads across diverse and extensive landscapes. There is no centralised remote sensing and GIS facility within 2000 kilometres of the CDU, Darwin. The upgraded infrastructure at CDU will assist in strengthening the research base in this remote part of Australia. This will allow the NT researchers to focus on the environmental applications of remote sensing and ....Satellite remote sensing and GIS data processing facilities at Charles Darwin University, Darwin. Northern Australia is vast, remote and spreads across diverse and extensive landscapes. There is no centralised remote sensing and GIS facility within 2000 kilometres of the CDU, Darwin. The upgraded infrastructure at CDU will assist in strengthening the research base in this remote part of Australia. This will allow the NT researchers to focus on the environmental applications of remote sensing and GIS technologies which will have many community benefits through better management of water resources, land degradation, wetlands, cultural knowledge and sustainable use of Australian biodiversity. The infrastructure will also assist in the training of new researchers within this developing field.
Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less