NPY Suppresses Seizures And Modulates Thalamocortical Activity In Animal Models Of Generalized Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$386,020.00
Summary
Epilepsy is the most common serious chronic neurological disease in the community, affecting up to 3% of the population in a lifetime and 0.5-1% at any one time. Absence epilepsy is one of the most common types of epilepsy, most frequently seen in childhood and teenage years that may persist into adulthood. Anti-epileptic drugs are effective in controlling absence seizures in most patients, however there is an important group (20-40%) of patients in whom the absence seizures remain uncontrolled ....Epilepsy is the most common serious chronic neurological disease in the community, affecting up to 3% of the population in a lifetime and 0.5-1% at any one time. Absence epilepsy is one of the most common types of epilepsy, most frequently seen in childhood and teenage years that may persist into adulthood. Anti-epileptic drugs are effective in controlling absence seizures in most patients, however there is an important group (20-40%) of patients in whom the absence seizures remain uncontrolled with current medications. Recently there has been considerable interest in the role that chemical in the brain, such as neuropeptide Y (NPY), may play in epilepsy. The research proposed will examine the role of NPY in several animal models of absence epilepsy. We have recently shown that NPY suppresses absence seizures in a rat genetic model of generalised epilepsy, and that this appears to be mediated by Y2 receptors. This work will build on these novel findings, and determine the localisation of the effect within the brain, and the underlying mechanism. We will check NPY effects across several models in different species, a genetic rat model with spontaneous seizures, and in mice treated with a chemical to induce seizures. This will determine its broad applicability. We will also determine the effects of removal of NPY or NPY receptors on the effects of NPY on seizure expression. Finally, brain recording techniques will be applied to determine the mechanism and site within the brain underlying the protective actions of NPY. The project has the potential to provide novel insights into the role of NPY in the expression and modulation of absence seizures. NPY related mechanisms might represent targets for the development of a new class of therapeutic agents for the treatment of absence epilepsy. Targets that are identified as being important in the expression of absence seizures may also prove to be relevant in other types of generalised epilepsy syndromes.Read moreRead less
Targeting NPY Mechanisms In Rodent Models Of Generalised Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$437,637.00
Summary
This project will provide important information regarding the pharmacological mechanisms by which NPY acts to suppress seizures in animal models of epilepsy. It will provide strategies regarding potential new treatments of absence epilepsy.
The Effect of Historical-Investigative Teaching about Pendulum Motion on High School Students Understanding of the Nature of Science. This project will investigate the impact of historical investigative teaching about pendulum motion on students understanding of the nature of science - its methodology, its relationship to technology, and its interrelationship with society and culture. The project emerges from my well-reviewed book "Time for Science Education" (Kluwer,2000) that discusses the his ....The Effect of Historical-Investigative Teaching about Pendulum Motion on High School Students Understanding of the Nature of Science. This project will investigate the impact of historical investigative teaching about pendulum motion on students understanding of the nature of science - its methodology, its relationship to technology, and its interrelationship with society and culture. The project emerges from my well-reviewed book "Time for Science Education" (Kluwer,2000) that discusses the historical, methodological, technical and social aspects of the discovery of the laws of pendulum motion in the 17th Century. As the pendulum is a ubiquitous topic in primary and secondary school science programmes, the approach could make a significant contribution to raising public understanding of science.Read moreRead less
Assessment practices: Empowering mathematics and science teachers in rural areas to improve student learning and curriculum implementation. The philosophy behind this research is that assessment needs to be informative and useful for both teacher and learner. For this to happen, there has to be a ?constructive alignment? of curriculum content, pedagogy, and assessment. This research employs empirically-based qualitative assessment techniques, which complement traditional assessment practices, ....Assessment practices: Empowering mathematics and science teachers in rural areas to improve student learning and curriculum implementation. The philosophy behind this research is that assessment needs to be informative and useful for both teacher and learner. For this to happen, there has to be a ?constructive alignment? of curriculum content, pedagogy, and assessment. This research employs empirically-based qualitative assessment techniques, which complement traditional assessment practices, as the foundation for teachers to make this synthesis in mathematics and science in rural schools in NSW. The significance of the research is in the insights it offers to how teachers can improve the learning environment for their students by addressing more appropriately student needs and higher learning outcomes.Read moreRead less
Impact of Developmentally-based Qualitative Assessment Practices in English, Mathematics, and Science on School Policies, Classroom Instruction, and Teacher Knowledge. This project aims to investigate and analyse issues concerning qualitative assessment techniques that measure students? understandings in English, Mathematics and Science, Years 7 to 10, in Government Schools in NSW. The significance lies in the advice that will be provided to school systems, subject departments and teachers on h ....Impact of Developmentally-based Qualitative Assessment Practices in English, Mathematics, and Science on School Policies, Classroom Instruction, and Teacher Knowledge. This project aims to investigate and analyse issues concerning qualitative assessment techniques that measure students? understandings in English, Mathematics and Science, Years 7 to 10, in Government Schools in NSW. The significance lies in the advice that will be provided to school systems, subject departments and teachers on how assessment information can improve the learning environment for students. Expected outcomes include details on how to utilise qualitative and quantitative assessment practices; detailed longitudinal analyses of teacher growth and perceptions as a result of using theoretically-based assessment practices within the social context of NSW classrooms.Read moreRead less
Centre For Translational Neuroscience: A Modular Platform For Translating Discovery Into Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$2,623,735.00
Summary
Clinical Centre of Research Excellence in Translational Neuroscience will provide people, pathways and resources to create a novel platform to take the outputs of Neuroscience Discovery programs though to improved patient outcomes for common brain diseases. A critical role will be to train and equip the best and brightest of the next generation of researchers to undertake internationally competitive translational neuroscience research that makes a difference to the health of our community.
Generating Science Content Knowledge through Digital Animation in a Knowledge-building Community of Preservice Teachers. Sustaining Australia's growth and prosperity is dependent on continuous innovation in the teaching of science. Yet science is one of the least taught subjects in the primary curriculum because teachers lack content knowledge and confidence. This research engages preservice primary teachers in using new technologies to develop their understanding of science content knowledge th ....Generating Science Content Knowledge through Digital Animation in a Knowledge-building Community of Preservice Teachers. Sustaining Australia's growth and prosperity is dependent on continuous innovation in the teaching of science. Yet science is one of the least taught subjects in the primary curriculum because teachers lack content knowledge and confidence. This research engages preservice primary teachers in using new technologies to develop their understanding of science content knowledge through digital animation and to collaborate with other preservice teachers interstate and internationally. The products and processes of digital animation will help maintain and expand Australia's base as a knowledge economy as well as provide a social benefit of improved science teaching in schools. Read moreRead less
Supporting personalised learning in secondary schools through the use of specific mathematics assessments that reveal thinking. This project will improve numeracy standards in secondary schools, by assisting teachers to personalise the teaching of each student. Through detailed research, the project will develop sophisticated assessments that clearly reveal students' mathematical thinking. On-line diagnosis will suggest teaching activities that can bring about desired conceptual changes. The eff ....Supporting personalised learning in secondary schools through the use of specific mathematics assessments that reveal thinking. This project will improve numeracy standards in secondary schools, by assisting teachers to personalise the teaching of each student. Through detailed research, the project will develop sophisticated assessments that clearly reveal students' mathematical thinking. On-line diagnosis will suggest teaching activities that can bring about desired conceptual changes. The effectiveness of the resources will be thoroughly tested, for impact on student achievement and the mathematics teaching skills of teachers, especially those working out-of-field. Rural schools will have equal access to these resources. Good numeracy provides the foundation for life-long learning, employment satisfaction and the economic competitiveness of Australia.Read moreRead less
Disciplinarity and classroom practice: Epistemological issues in the analysis and improvement of teaching and learning. Demands on levels of content and technical knowledge are accelerating from many employment sectors in Australia and elsewhere. In addition, there is an increasing need to apply knowledge to complex problems in innovative and flexible ways and in authentic settings not readily simulable in traditional schooling. The proposed project addresses fundamental questions about epistemo ....Disciplinarity and classroom practice: Epistemological issues in the analysis and improvement of teaching and learning. Demands on levels of content and technical knowledge are accelerating from many employment sectors in Australia and elsewhere. In addition, there is an increasing need to apply knowledge to complex problems in innovative and flexible ways and in authentic settings not readily simulable in traditional schooling. The proposed project addresses fundamental questions about epistemology, curriculum, and everyday classroom practice. It offers novel and evidence-based approaches to the building of discipline-based knowledge, and thus has powerful implications for the revitalising of Australian education to meet the urgent requirements of new economic, technological, and cultural times put pressures on education. Read moreRead less
Innovative Approaches to Shakespeare and Literature Research in Australian Universities and Secondary Schools. Barker College and the University of Sydney unite in a major research initiative to tackle pressing issues in Australian humanities education with the express purpose of promoting an innovation culture and economy (National Research Priority 3, Goal 5). The project executes groundbreaking research into the teaching and learning of Shakespeare and the literary-critical skills of school a ....Innovative Approaches to Shakespeare and Literature Research in Australian Universities and Secondary Schools. Barker College and the University of Sydney unite in a major research initiative to tackle pressing issues in Australian humanities education with the express purpose of promoting an innovation culture and economy (National Research Priority 3, Goal 5). The project executes groundbreaking research into the teaching and learning of Shakespeare and the literary-critical skills of school and university students. The core research partnership, website and conference together deliver a shared-knowledge approach to determining innovative and effective new models for teaching and learning in the humanities. The project seeks wide participation from, and delivers diverse pedagogical benefits to, all Australian schools and universities.Read moreRead less