Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100121
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Three-dimensional super-resolution nanophotonic fabrication facility. This stimulated emission depletion microscopy nanophotonic fabrication facility will be the first nanophotonic fabrication facility that is able to achieve optical resolution far beyond the diffraction limit, which will facilitate breakthroughs in cutting-edge nanotechnology research areas.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100124
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Rapid prototyping 3-D nano-pattern large area writer . Rapid prototyping 3-D nano-pattern large area writer:
The project aims to establish a nanoscale three-dimensional patterning rapid prototyping capability to enable advanced nanofabrication research and development. The extension of patterning nanostructured materials in three dimensions with nanometre resolution, developed for semiconductor processing, to nano-electronics, nanophotonics, nanosensors, nanobiotechnology and fundamental studi ....Rapid prototyping 3-D nano-pattern large area writer . Rapid prototyping 3-D nano-pattern large area writer:
The project aims to establish a nanoscale three-dimensional patterning rapid prototyping capability to enable advanced nanofabrication research and development. The extension of patterning nanostructured materials in three dimensions with nanometre resolution, developed for semiconductor processing, to nano-electronics, nanophotonics, nanosensors, nanobiotechnology and fundamental studies of nanoscale phenomena in science and engineering has opened new opportunities in these areas. As these areas accelerate, there is a need to develop nanoscale patterns and structures via rapid prototyping pathways and with methods accessible to an ever-diverse researcher base without a background in nanofabrication. By establishing the first NanoFrazor in Australia, this project aims to provide new technology for the fabrication of high-resolution nanoscale structures and patterns.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100003
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
3D Nanofabrication and Nanocharacterisation facility. This project aims to establish a revolutionary nanoscale fabrication and characterisation facility in Australia. The facility is an angle-based nanoscale etching system with integrated chemical analysis capabilities and will be the first instrument of its kind in Australia. The facility will enable unprecedented fabrication and characterisation of 3D nanostructures and new device geometries from semiconductors, oxides and metals that underpin ....3D Nanofabrication and Nanocharacterisation facility. This project aims to establish a revolutionary nanoscale fabrication and characterisation facility in Australia. The facility is an angle-based nanoscale etching system with integrated chemical analysis capabilities and will be the first instrument of its kind in Australia. The facility will enable unprecedented fabrication and characterisation of 3D nanostructures and new device geometries from semiconductors, oxides and metals that underpin modern nanoelectronics for innovative energy, nano-optical and quantum device applications. This unique equipment will facilitate breakthrough discoveries in nanomaterials, and foster collaborations amongst Australian researchers to accelerate industry in advanced nanodevice technologies.Read moreRead less
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100147
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
Advanced ultrasonic spray deposition system for large area solar cells fabrication. Low cost, low carbon forms of power generation are required to enable Australia to minimise its greenhouse gas emissions. Traditional solar cells are manufactured using high cost, low volume production methods which will in future be complemented by the introduction of low cost, high volume printed organic solar cells. Spray deposition of active materials will allow the formation of active solar cells on many n ....Advanced ultrasonic spray deposition system for large area solar cells fabrication. Low cost, low carbon forms of power generation are required to enable Australia to minimise its greenhouse gas emissions. Traditional solar cells are manufactured using high cost, low volume production methods which will in future be complemented by the introduction of low cost, high volume printed organic solar cells. Spray deposition of active materials will allow the formation of active solar cells on many new materials, thus opening up new ways of using solar cells and hence new markets or export opportunities. The research is aimed at delivering a local research-driven industry which is export-oriented, thus assisting Australia to reach its carbon reduction targets.Read moreRead less
van der Waals epitaxy for advanced and flexible optoelectronics. This project aims to investigate the growth of compound semiconductors directly on two-dimensional material templates, via the so-called van der Waals epitaxy. Two-dimensional materials combined with compound semiconductors as optoelectronic materials can have many uses. This project expects to design flexible solar cells, which could be integrated with fabrics or building products, and lasers that need small drive currents. It wil ....van der Waals epitaxy for advanced and flexible optoelectronics. This project aims to investigate the growth of compound semiconductors directly on two-dimensional material templates, via the so-called van der Waals epitaxy. Two-dimensional materials combined with compound semiconductors as optoelectronic materials can have many uses. This project expects to design flexible solar cells, which could be integrated with fabrics or building products, and lasers that need small drive currents. It will use the Anderson localisation effect, a photon management concept, to control the interaction between photons and material and improve device efficiencies.Read moreRead less
Apoptosis And Stem Cells In Cancer Development And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$22,852,198.00
Summary
To improve cancer therapy, we are studying two cancer hallmarks: enhanced cell survival and stem cell-like behaviour. As we discovered, cell death is often blocked in cancer cells. Hence, we are attempting to develop drugs that flip the natural ‘cell death switch’. Stem cells are rare cells that generate entire tissues, as we showed for the breast. Certain cancers may be driven by ‘rogue’ stem cells. If so, eradication of these rare cells within the bulk tumour may require novel therapies.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Plasmonic Photochemistry: A nanoscopic solution to global energy and environmental problems. Harvesting energy from light sources, including our sun, can provide a significant fraction of the world's energy need over the next century. In order to meet this critical demand, it is crucial to devise ways to transform light energy into chemical fuels. This project aims to create novel nanostructures that directly couple light energy into chemical reactions. This will be achieved by the creation of ....Plasmonic Photochemistry: A nanoscopic solution to global energy and environmental problems. Harvesting energy from light sources, including our sun, can provide a significant fraction of the world's energy need over the next century. In order to meet this critical demand, it is crucial to devise ways to transform light energy into chemical fuels. This project aims to create novel nanostructures that directly couple light energy into chemical reactions. This will be achieved by the creation of metallic nanoparticles that can transform light energy into hot electrons: entities that can efficiently drive the production of chemical fuels in a process similar to that of photosynthesis.Read moreRead less
Engineered ion channels for selective and switchable ion conduction. This project aims to develop an innovative bioinspired approach for fabricating angstrom-sized ion-channel membranes with specific ion selectivity, high ion conductivity and efficient gating function comparable to biological ion channels. Engineering of artificial channels with ion-channel-like shapes, ion selectivity filters and functional gates is expected to bring high-efficiency technologies to applications such as membrane ....Engineered ion channels for selective and switchable ion conduction. This project aims to develop an innovative bioinspired approach for fabricating angstrom-sized ion-channel membranes with specific ion selectivity, high ion conductivity and efficient gating function comparable to biological ion channels. Engineering of artificial channels with ion-channel-like shapes, ion selectivity filters and functional gates is expected to bring high-efficiency technologies to applications such as membrane separation and energy conversion. This project has potential to result in new knowledge of biomimetic design of artificial ion-channel membranes and directly benefit manufacturing industry for Australia.Read moreRead less