This Program studies the mechanisms that control blood cell formation and how abnormalities play a role in leukaemia, a significant health problem worldwide. Despite some improvements, two major problems remain: controlling progression of leukaemia and relapse. The Program tackles these two major issues with the combination of studies of normal blood and leukaemia cell function, drug design and clinical trials ensuring a direct pathway from discovery to patient benefit.
Central to improving the management of patients with cancer is an understanding of the molecular drivers of cancer. Based on our fundamental discoveries about the role of cell growth and perturbed cell signalling as drivers of cancer we will use the integration of molecular and imaging biomarkers with targeted therapies to translate this knowledge into better outcomes for cancer patients with defined molecular drivers of their cancer.
Understanding The Major Class Of Cell Surface Drug Targets
Funder
National Health and Medical Research Council
Funding Amount
$7,595,840.00
Summary
G Protein-Coupled Receptors (GPCRs) form the largest family of receptors and drug targets in living organisms. Currently, the major reason that new drugs fail to reach the clinic is lack of appropriate drug effect (approx. 30%). Thus, we need a better understanding of how GPCRs work and how this relates to disease. Our Program addresses this knowledge gap, using GPCR models that are relevant to treatment of metabolic, inflammatory, cardiovascular and central nervous system disease.
MOTOR IMPAIRMENT: Basic And Applied Human Neurophysiology
Funder
National Health and Medical Research Council
Funding Amount
$6,830,980.00
Summary
Motor Impairment results in physical disability in a wide range of debilitating diseases and health conditions. We will conduct a research program that will include both experimental investigations and clinical trials to identify optimal strategies for maximising physical functioning for people with weakness and fatigue, impaired sensation and balance, and contracture. In doing so, our program offers great scope for improving the health and quality of life for millions of Australians and substan ....Motor Impairment results in physical disability in a wide range of debilitating diseases and health conditions. We will conduct a research program that will include both experimental investigations and clinical trials to identify optimal strategies for maximising physical functioning for people with weakness and fatigue, impaired sensation and balance, and contracture. In doing so, our program offers great scope for improving the health and quality of life for millions of Australians and substantially reducing health care costs.Read moreRead less