Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Prion-like Behaviour In Immunity: Super-sized Signalling Platforms?
Funder
National Health and Medical Research Council
Funding Amount
$611,995.00
Summary
Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.
Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Group orbits in garmonic analysis and ergodic theory. Researchers from many areas need a type of mathematical analysis which involves the behaviour of a system - which may be a set of data points - under repeated application of some operation or group of operations. The structures arising from this kind of process are known as group orbits. The project gives information about their nature. Two major types of orbits are considered, coming from actions of discrete groups on measure spaces, and fro ....Group orbits in garmonic analysis and ergodic theory. Researchers from many areas need a type of mathematical analysis which involves the behaviour of a system - which may be a set of data points - under repeated application of some operation or group of operations. The structures arising from this kind of process are known as group orbits. The project gives information about their nature. Two major types of orbits are considered, coming from actions of discrete groups on measure spaces, and from smooth actions of Lie groups on manifolds, where powerful geometric methods are available. The project will yield new understandings of entropy, and new approaches to Fourier analysis.Read moreRead less
Ergodic theory and number theory. Recent advances in the theory of measured dynamical systems investigated by the proponents include new versions of entropy, and the study of spectral theory for non-singular systems. These will be further developed in this joint project with the French CNRS. The results are expected to have interesting applications in physics and number theory.
Entropy and maximal entropy in Markov systems. Entropy is a measure of how well-ordered a system is: chaotic systems have high entropy. Two approaches to entropy are available, via the limiting behaviour of the orbits of points, which yields topological entropy, and via the behaviour of the distributions of measures of partitions, yielding measure-theoretic entropy. The topological entropy is the least upper bound of entropies of all possible measures. We study when there is a measure which real ....Entropy and maximal entropy in Markov systems. Entropy is a measure of how well-ordered a system is: chaotic systems have high entropy. Two approaches to entropy are available, via the limiting behaviour of the orbits of points, which yields topological entropy, and via the behaviour of the distributions of measures of partitions, yielding measure-theoretic entropy. The topological entropy is the least upper bound of entropies of all possible measures. We study when there is a measure which realises this bound, describing the structure of such systems via Markov and Bratteli diagrams. Our methods will be applied to new versions of entropy for non-singular systems. This will assist in the description of chaotic behaviour.Read moreRead less
Symmetries in analysis. Technical research is like an iceberg. The 10% you see in applications is supported by 90% hidden, long-term, sometimes abstruse or theoretical-sounding work. The area of mathematical analysis has, for over 200 years, proved its worth as part of the unseen 90%, giving us such important tools as Fourier analysis, statistical mechanics and quantum mechanics. Australia is known as a world leader in mathematical analysis, and it is important for the country to maintain that e ....Symmetries in analysis. Technical research is like an iceberg. The 10% you see in applications is supported by 90% hidden, long-term, sometimes abstruse or theoretical-sounding work. The area of mathematical analysis has, for over 200 years, proved its worth as part of the unseen 90%, giving us such important tools as Fourier analysis, statistical mechanics and quantum mechanics. Australia is known as a world leader in mathematical analysis, and it is important for the country to maintain that edge in a number of key disciplines, so we can continue to participate in global technological advance. The project has an international focus which will enable that to happen. It will also provide training for the next generation of mathematicians. Read moreRead less
Dynamical systems: theory and practice. Mathematical science has proven a crucial platform for science and technology: it may have a long lead-time to application but its impacts are more profound than glamorous technical developments. Australia has an economic imperative to maintain investment in fundamental mathematics. Dynamical systems underpin a wide range of applications in physics, engineering, information science, finance and economics. This project will improve our capacity to model sy ....Dynamical systems: theory and practice. Mathematical science has proven a crucial platform for science and technology: it may have a long lead-time to application but its impacts are more profound than glamorous technical developments. Australia has an economic imperative to maintain investment in fundamental mathematics. Dynamical systems underpin a wide range of applications in physics, engineering, information science, finance and economics. This project will improve our capacity to model systems and to study their evolution, giving us better predictive power. It will keep Australia in the forefront of international research, providing a basis of expertise not otherwise available to Australian researchers and industry. Read moreRead less
Non-commutative analysis and differential calculus. This project is in an area of central mathematical importance and will lead to important scientific advances that will keep Australia at the forefront internationally in this field of research. There is an emphasis on international networking and we will collaborate with leading researchers in USA and France.