Age-and Species-related Regulation Of Host Inflammatory Responses In Falciparum And Vivax Malaria
Funder
National Health and Medical Research Council
Funding Amount
$323,640.00
Summary
Malaria kills 1 million people every year, mostly children. The cause of death from malaria differs between children and adults, yet the reason for these differences is unknown. We have shown that in adults regulatory immune cells contribute to malaria disease complications. We want to test if these cells also worsen malaria disease in children. Understanding age-related differences in immune cell regulation will help to improve malaria treatment and aid development of effective malaria vaccines ....Malaria kills 1 million people every year, mostly children. The cause of death from malaria differs between children and adults, yet the reason for these differences is unknown. We have shown that in adults regulatory immune cells contribute to malaria disease complications. We want to test if these cells also worsen malaria disease in children. Understanding age-related differences in immune cell regulation will help to improve malaria treatment and aid development of effective malaria vaccines for adults and children.Read moreRead less
Dysregulation Of Cytokine Networks: A Key Determinant Of The Pathogenesis Of Cerebral Malaria.
Funder
National Health and Medical Research Council
Funding Amount
$480,989.00
Summary
Malaria is a parasitic disease that kills some 2 million people each year. It affects the Australian region, e.g. PNG and SE Asia. One of the most serious complications is cerebral malaria (CM). It affects the brain and is often fatal. This project will show whether the early meeting of the malaria parasite with the host's immune system determines if the infection will be a mild, resolving one or a severe, possibly lethal one causing CM. This is highly relevant to vaccine development strategies.