Oxygenation history of the Earth and the evolution of complex life. This project will investigate how and when the atmosphere became oxygen-rich by analyzing ancient barrier reefs and other rocks that formed between 1000 to 300 million years ago, spanning the appearance and diversification of animals and plants. The project is significant because the buildup of oxygen in the atmosphere was arguably the most important chemical process ever to have occurred on Earth and controlled the evolution of ....Oxygenation history of the Earth and the evolution of complex life. This project will investigate how and when the atmosphere became oxygen-rich by analyzing ancient barrier reefs and other rocks that formed between 1000 to 300 million years ago, spanning the appearance and diversification of animals and plants. The project is significant because the buildup of oxygen in the atmosphere was arguably the most important chemical process ever to have occurred on Earth and controlled the evolution of environments, climate and life. A major outcome will be an improved understanding of how the Earth's atmosphere and climate are regulated by geological processes. This project will generate new knowledge about how sedimentary zinc, lead and copper ore deposits form, which may guide exploration for these commodities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100988
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
The oxygenation of Earth’s early marine ecosystems. This project aims to map out the complex evolution of the Earth’s ocean ecosystems and oxygenation using marine carbonates. The oxygenation of Earth’s surface is one of the most profound processes to shape the planet, affecting all biological and geological systems. However, uncertainties remain in the timing of oxygenation and how it relates to the evolution of life. This project will develop our understanding of how Earth has remained habitab ....The oxygenation of Earth’s early marine ecosystems. This project aims to map out the complex evolution of the Earth’s ocean ecosystems and oxygenation using marine carbonates. The oxygenation of Earth’s surface is one of the most profound processes to shape the planet, affecting all biological and geological systems. However, uncertainties remain in the timing of oxygenation and how it relates to the evolution of life. This project will develop our understanding of how Earth has remained habitable through significant intervals of environmental change. Using the geology of Australia, and elsewhere, this project is expected to derive the oxygenation evolution of ancient seawater and its effect on reef ecosystems during critical intervals of Earth’s history.Read moreRead less
The role of phosphoinositides in endosomal maturation dynamics. This project aims to investigate the regulation of an intracellular compartment within a cell called endosomes, which plays critical roles in cellular homeostasis, signalling and pathogen entry. New knowledge is expected to be generated in understanding endosome maturation and the signalling events that drive this process using a unique, multidisciplinary approach combining state of the art imaging techniques and high throughput pro ....The role of phosphoinositides in endosomal maturation dynamics. This project aims to investigate the regulation of an intracellular compartment within a cell called endosomes, which plays critical roles in cellular homeostasis, signalling and pathogen entry. New knowledge is expected to be generated in understanding endosome maturation and the signalling events that drive this process using a unique, multidisciplinary approach combining state of the art imaging techniques and high throughput protein analysis. The anticipated outcomes will be to define the molecular steps that govern the membrane-bound machinery on endosomes that directs endosomal maturation. This should provide significant benefits in delineating a process that is linked to almost all aspects of cell life.Read moreRead less
Deciphering novel cross-talk between innate cytokine receptors. Understanding the basic functions of interferons, how they signal to cells, is central to understanding fundamental immunity. Interferons are crucial molecules of the immune system that are important for normal cell development and they protect the body from viral infection and cancer but can be deleterious in different autoimmune diseases and trauma settings. Preliminary Data shows there is a pathway of interferon signalling that h ....Deciphering novel cross-talk between innate cytokine receptors. Understanding the basic functions of interferons, how they signal to cells, is central to understanding fundamental immunity. Interferons are crucial molecules of the immune system that are important for normal cell development and they protect the body from viral infection and cancer but can be deleterious in different autoimmune diseases and trauma settings. Preliminary Data shows there is a pathway of interferon signalling that has previously been overlooked. This project aims to understand how this pathway works and how it contributes to the normal workings of cells. This fundamental science has future consequences for the design of vaccines and for the design of therapeutics to treat diseases that show defective interferon signalling.Read moreRead less
New Stratigraphy and Geostatistics for Gas and Water Resources . Management of gas and water resources is of significant importance to the Australian economy and society. Industry and government use digital modelling to assist in resources management. The first step in modelling is to correlate geological data and then use geostatistics to estimate properties in areas without data. This project aims to produce a new geological framework for the Surat Basin underpinned by new zircon ages and ages ....New Stratigraphy and Geostatistics for Gas and Water Resources . Management of gas and water resources is of significant importance to the Australian economy and society. Industry and government use digital modelling to assist in resources management. The first step in modelling is to correlate geological data and then use geostatistics to estimate properties in areas without data. This project aims to produce a new geological framework for the Surat Basin underpinned by new zircon ages and ages of fossils in sediments and a new geostatistical methodology to better represent flow properties in coal seams and aquifers. This is expected result in a more accurate modelling methodology that can be used by industry and government for modelling resources, including in other basins in Australia and worldwide.Read moreRead less
Understanding the mechanisms of class B GPCR-transducer coupling. Current effort in developing drugs targeting G protein-coupled receptors (GPCRs) often result in low success rate due to the lack of understanding of the complexity and the spatiotemporal control of receptor function. The research program aims to understand the molecular mechanisms of receptor/transducer selectivity. The proposal integrated multi-disciplinary approaches to provide a deeper understanding of how the receptor is acti ....Understanding the mechanisms of class B GPCR-transducer coupling. Current effort in developing drugs targeting G protein-coupled receptors (GPCRs) often result in low success rate due to the lack of understanding of the complexity and the spatiotemporal control of receptor function. The research program aims to understand the molecular mechanisms of receptor/transducer selectivity. The proposal integrated multi-disciplinary approaches to provide a deeper understanding of how the receptor is activated responding to different ligands. The anticipated outcome including an enhanced capacity for understanding the fundamental biology, a stronger national and international collaborations. This will provide significant benefits including expanded basic knowledge and improvements in drug development efficiency. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100259
Funder
Australian Research Council
Funding Amount
$467,964.00
Summary
Interrogating the adaptive potential of skeletal muscle. Disruptions to muscle oxidative capacity and growth signalling underpin atrophy and dysfunction with ageing, which impacts on an individual’s quality of life. These biological processes are thought to be mutually exclusive and compete during muscle adaptation. This project aims to define how these processes regulate the extent of muscle adaptation, and how modifying these attributes influence functional capacity in the context of ageing. T ....Interrogating the adaptive potential of skeletal muscle. Disruptions to muscle oxidative capacity and growth signalling underpin atrophy and dysfunction with ageing, which impacts on an individual’s quality of life. These biological processes are thought to be mutually exclusive and compete during muscle adaptation. This project aims to define how these processes regulate the extent of muscle adaptation, and how modifying these attributes influence functional capacity in the context of ageing. This project will provide fundamental new knowledge in understanding how modifying muscle attributes influence successful ageing. This knowledge will improve resilience, productivity, and wellbeing of all Australians, with implications for reducing societal and economic burden.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100501
Funder
Australian Research Council
Funding Amount
$349,446.00
Summary
A novel radio access network for wireless communication networks. This project aims to investigate a novel network architecture that supports ultra-reliable access and coverage for future generation wireless communications. Based on recent developments in fog computing, the project aims to redefine the radio access network of wireless systems to shift from traditional, static cell-centric architecture to a more dynamic cell-free architecture. The intended outcomes of the research are an adaptive ....A novel radio access network for wireless communication networks. This project aims to investigate a novel network architecture that supports ultra-reliable access and coverage for future generation wireless communications. Based on recent developments in fog computing, the project aims to redefine the radio access network of wireless systems to shift from traditional, static cell-centric architecture to a more dynamic cell-free architecture. The intended outcomes of the research are an adaptive network architecture that dynamically forms serving clusters, secure communications protocols that decrease latency and increase communication security and energy-efficient signal processing techniques that support green communications.Read moreRead less
The molecular basis for efficacy at G protein coupled receptors. This project aims to investigate the molecular steps underlying the relationship between sensing by signal-transmitting proteins on the cell surface called G protein-coupled receptors and cellular response. The project aims to build on studies that have sought to understand the primary, molecular basis for this cellular volume control. This project seeks to use these novel approaches to fill this knowledge gap, providing a deeper u ....The molecular basis for efficacy at G protein coupled receptors. This project aims to investigate the molecular steps underlying the relationship between sensing by signal-transmitting proteins on the cell surface called G protein-coupled receptors and cellular response. The project aims to build on studies that have sought to understand the primary, molecular basis for this cellular volume control. This project seeks to use these novel approaches to fill this knowledge gap, providing a deeper understanding of how physiology and medicines work. The project expects to expand fundamental understanding of signal transmission at this receptor class. This project will deliver benefits including expanded basic knowledge and a contribution to future improvements in drug development.Read moreRead less