The Role Of Dopamine And Other Neuromodulators As Light Signals In The Inner Retina: A Link To Night Blindness Disorders
Funder
National Health and Medical Research Council
Funding Amount
$250,250.00
Summary
Although most human activities can be performed at night as efficiently as during daytime due to the use of artificial light, normal function of the circuits underlying night vision is critical. For example, when driving at night in a poorly illuminated road where the region illuminated by the headlights is processed by the cone circuit that serves daylight in the retina whilst the peripheral areas are processed by the rod driven nighttime circuit. Impairment of night vision and of the dark-ligh ....Although most human activities can be performed at night as efficiently as during daytime due to the use of artificial light, normal function of the circuits underlying night vision is critical. For example, when driving at night in a poorly illuminated road where the region illuminated by the headlights is processed by the cone circuit that serves daylight in the retina whilst the peripheral areas are processed by the rod driven nighttime circuit. Impairment of night vision and of the dark-light switch can have fatal consequences. Night blindness is a symptom characterised by reduced vision in the dark and slow adaptation to dim light. Some congenital night blindness disorders are caused by mutations in the photoreceptor calcium channels which mediate signal transmission. Additionally, patients treated with neuroleptics, a group of drugs which affect the dopaminergic system, suffer night vision disorders. Dopamine acts as a light signal in the retina. AII amacrine cells are pivotal neurones for night vision segregating two channels (ON and OFF) which convey visual information. AII cells are modulated by dopamine and thus, represent interesting targets to study the role of dopamine in the dark-light switch. Much is know about the action of dopamine on transmission of ON signals channelled by AII cells. However, its action on the OFF channel is largely unknown. We believe that some night vision disorders originate by imbalance in the dopaminergic system in the retina and its effects on AII cells. We will test our hypothesis by studying the modulatory effect of dopamine on calcium dependent signal transmission between AII cells and their partners in the OFF channel. Our hypothesis will be further tested by using animal models in which dopamine receptor function is altered. The results of these studies will provide us with an invaluable model to understand the physiological basis of the dark-light switch and of the role of dopamine in night vision disorders.Read moreRead less
Optimum Multi-rate Filter Bank Design for Speech Enhancement and Communication Systems. Multi-rate signal processing is gaining more and more importance in signal processing applications such as echo cancellation, microphone arrays, speech enhancement and equalisation. This project is aimed at obtaining high performance and high efficiency multi-rate processing designs by developing appropriate problem formulations based on solid mathematical foundations so that powerful optimisation techniques ....Optimum Multi-rate Filter Bank Design for Speech Enhancement and Communication Systems. Multi-rate signal processing is gaining more and more importance in signal processing applications such as echo cancellation, microphone arrays, speech enhancement and equalisation. This project is aimed at obtaining high performance and high efficiency multi-rate processing designs by developing appropriate problem formulations based on solid mathematical foundations so that powerful optimisation techniques can be applied. The developed multi-rate systems will result in low complexity and low power hardware implementations without significant compromise in performance in each application. Size and cost sensitive of communication devices such as personal data assistants, mobile telephones, hands-free devices, and laptops will benefit greatly from the outcome of the project.Read moreRead less
Design and analysis of optimum space-frequency-time codes for multi-rate OFDM Systems. This research work contributes to the ones of the major national
research priorities, the frontier ICT technology. It addresses the issues of a frontier ICT technology. Output of the project will place the Australia in the map of 4-th generation mobile and wireless communications research. These results will also influence the implementation aspects of future mobile communication systems and
attract the att ....Design and analysis of optimum space-frequency-time codes for multi-rate OFDM Systems. This research work contributes to the ones of the major national
research priorities, the frontier ICT technology. It addresses the issues of a frontier ICT technology. Output of the project will place the Australia in the map of 4-th generation mobile and wireless communications research. These results will also influence the implementation aspects of future mobile communication systems and
attract the attention of the international community. Other major
national benefit of the project is the training of PhD students
and the production of potential researchers for 4G research.Read moreRead less
Optimisation-based analysis and synthesis of sparse systems in signal processing and communication. This project will make onceptual advances in the areas of signal processing and communication. A major benefit of this project will be its direct applications to digital industry - perhaps the major electrical industry of our era. The project will also aim to build a world class research activity at the University of New South Wales to focus attention on low-cost signal processing and communicatio ....Optimisation-based analysis and synthesis of sparse systems in signal processing and communication. This project will make onceptual advances in the areas of signal processing and communication. A major benefit of this project will be its direct applications to digital industry - perhaps the major electrical industry of our era. The project will also aim to build a world class research activity at the University of New South Wales to focus attention on low-cost signal processing and communication, increase capacity for contract research, enhance nternational collaboration with leading researchers in the area, and produce quality PhD graduates in the field of signal processing and communication.Read moreRead less
Coherent Optical Orthogonal Frequency-Division Multiplexing. Coherent optical orthogonal frequency-division multiplexing (CO-OFDM) incorporates the benefits of OFDM to compensate for distortion and monitor the channel conditions in long-haul optical links. The advantages of CO-OFDM can help meet the challenges of future optical networks that Australia depends upon for its information infrastructure and economic growth. Australia is currently at the forefront of optical OFDM technology, and the ....Coherent Optical Orthogonal Frequency-Division Multiplexing. Coherent optical orthogonal frequency-division multiplexing (CO-OFDM) incorporates the benefits of OFDM to compensate for distortion and monitor the channel conditions in long-haul optical links. The advantages of CO-OFDM can help meet the challenges of future optical networks that Australia depends upon for its information infrastructure and economic growth. Australia is currently at the forefront of optical OFDM technology, and the continuation of these research activities will further improve Australia's international ICT reputation. Furthermore, in the course of the project, a senior research associate and multiple highly-skilled students will be trained and exposed to techniques and innovations in this exciting field.Read moreRead less
Broadband to the bush: Polarization as a new resource in wireless cross-layer design. 'Broadband to the Bush' is a national priority - more than 1.6 million homes, small businesses and not-for-profit organizations in rural, regional, and remote Australia are set to benefit from broadband access to phone networks and the internet. The immediate challenges lie in overcoming poor download speeds and area coverage, as well as expensive access. This research will deliver cost and power-efficient re ....Broadband to the bush: Polarization as a new resource in wireless cross-layer design. 'Broadband to the Bush' is a national priority - more than 1.6 million homes, small businesses and not-for-profit organizations in rural, regional, and remote Australia are set to benefit from broadband access to phone networks and the internet. The immediate challenges lie in overcoming poor download speeds and area coverage, as well as expensive access. This research will deliver cost and power-efficient receiver architectures to provide end-user utility, and will train postgraduate researchers across traditional discipline boundaries in mathematics and engineering. The project represents an important contribution to frontier technologies in information and communications technology for building and transforming Australian industries.Read moreRead less
Developing a Smart Monitoring System for Leakage Currents from Insulators on Wooden Poles. Numerous wooden poles are used for electricity power transmission in urban and rural areas of Australia. Insulators suspended on poles are subject to contamination and moisture that cause partial discharge currents to flow through the wooden poles, resulting in pole fires leading to loss of power to customers and possible bush fires. This project aims at studying the characteristics of leakage currents fr ....Developing a Smart Monitoring System for Leakage Currents from Insulators on Wooden Poles. Numerous wooden poles are used for electricity power transmission in urban and rural areas of Australia. Insulators suspended on poles are subject to contamination and moisture that cause partial discharge currents to flow through the wooden poles, resulting in pole fires leading to loss of power to customers and possible bush fires. This project aims at studying the characteristics of leakage currents from insulators on wooden poles in Australian conditions and developing a smart monitoring system to detect and prevent pole fires caused by leakage currents. The outcomes will reduce the risk of pole fires, hence improving public safety, reliability of power supply and sustainability of the Australian power industry.Read moreRead less
Pain Systems Analysis Highlights PI3K Gamma As A Candidate Regulator Of Nociception.
Funder
National Health and Medical Research Council
Funding Amount
$461,810.00
Summary
Chronic pain will affect most of us at one point in our life, and there is a need for new drugs to manage this condition. The goal of this project is to use our computer modeling of genetic data from multiple species to predict new drug targets, and then use mouse models to look at the mechanism of action for predicted drug targets, and validate one potential drug target in particular for its therapeutic abilities to stop chronic pain.
Next Generation Planar Tellurite Waveguides. The project provides the basis for the production of new high technology photonic products in Australia, the availability of at least one new unique facility for future scientific endeavour, and the generation of skillsets new to Australia. New IP will also be developed during the project. A successful outcome could also ultimately result in new products offering, for example, enhanced National Security through the Defence applications, better measure ....Next Generation Planar Tellurite Waveguides. The project provides the basis for the production of new high technology photonic products in Australia, the availability of at least one new unique facility for future scientific endeavour, and the generation of skillsets new to Australia. New IP will also be developed during the project. A successful outcome could also ultimately result in new products offering, for example, enhanced National Security through the Defence applications, better measurements of atmospheric contaminants through the sensing route, and more advanced telecommunications services at lower cost for citizens and businesses, and for lower operating costs for service providers.
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Special Research Initiatives - Grant ID: SR0354675
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Australian Communications Research Network (ACoRN). Information and Communication Technology is a key contributor to national productivity and growth. ACoRN aims to stimulate creativity, innovation and breakthrough science, leading to technological advancement in telecommunications. The focus is on development of fundamental theories for application to emerging wired and wireless communications technologies. Specific objectives include consolidation of existing linkages; facilitation of multidis ....Australian Communications Research Network (ACoRN). Information and Communication Technology is a key contributor to national productivity and growth. ACoRN aims to stimulate creativity, innovation and breakthrough science, leading to technological advancement in telecommunications. The focus is on development of fundamental theories for application to emerging wired and wireless communications technologies. Specific objectives include consolidation of existing linkages; facilitation of multidisciplinary research; formation of new links; stimulation of commercial activity; improved post-graduate education; and increased International prominence. Our current vision involves a range of programs including: undergraduate occupational training, postgraduate internships, national and international visiting programs, and seed funding for collaborative proposals.Read moreRead less