Small business job creation: employer and employee perspectives of job quality. Small business is high on the policy agenda as employment growth is trending downwards. Recent recommendations to increase small business employment highlight the importance of both quantity and job quality. This project will investigate what is a quality small business job from employer and employee perspectives. The research will focus on new small business jobs in the Latrobe Valley - a 'less favored' region. The ....Small business job creation: employer and employee perspectives of job quality. Small business is high on the policy agenda as employment growth is trending downwards. Recent recommendations to increase small business employment highlight the importance of both quantity and job quality. This project will investigate what is a quality small business job from employer and employee perspectives. The research will focus on new small business jobs in the Latrobe Valley - a 'less favored' region. The findings will fill a significant gap in knowledge about the process of job generation and lead to a better understanding of the determinants of job quality from different perspectives, which can assist economic policy development.Read moreRead less
Cell Surface Mucins In Gastrointestinal Infection, Inflammation And Cancer Development
Funder
National Health and Medical Research Council
Funding Amount
$469,627.00
Summary
Cell surface mucins are protective molecules that line all the wet surface of the body, including the gastrointestinal tract. Our research has uncovered that mucins regulate cell growth and cell death. Inappropriate control by the mucins, could lead to chronic inflammation and formation of cancers. We will test how important these molecules are in the development of cancers in the intestine, and further explore the mechanism of action.
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
Regulation Of NOD Signalling By IAPs And RIP Kinases
Funder
National Health and Medical Research Council
Funding Amount
$643,172.00
Summary
Alterations in NOD signalling have been implicated in various human inflammatory diseases, particularly in Crohn’s disease and asthma. In this project we will identify new molecules that regulate NOD signalling and test the effect of drugs that inhibit known components of these pathways to determine their utility in treating inflammatory diseases.
Host Cell Death Signaling And Susceptibility To Bacterial Gut Infection
Funder
National Health and Medical Research Council
Funding Amount
$682,321.00
Summary
Bacterial infections are a major cause of infectious disease worldwide. Here we aim to characterise immune responses that help fight infection by E. coli and Salmonella. These bacteria have evolved ways to shut down many of our immune responses during infection, allowing them to survive and cause disease. This work will help understand the complex relationship between gut bacteria and our immune system and provide solutions for controlling infection and treating immune disorders of the gut.
Chronic inflammation underlies common and debilitating diseases and causes pain by unknown mechanisms. There is an urgent need to gain a deeper understanding of the mechanisms of chronic pain, which will allow the development of improved therapies with fewer side-effects. Our research program investigates the mechanisms of pain that are associated with inflammatory bowel disease and irritable bowel syndrome, with the goal of developing more effective and selective therapies.
Family business and succession planning: dynamics, barriers and strategies. This research will generate better strategies, protocols and policies for family business succession planning, tailored to the Australian context. Family businesses constitute about 70-80 per cent of Australian businesses, and $4.5 trillion in business value. It is estimated that $3.5 trillion of business value will change hands in the next decade as the post-war generation of business founders moves on. Yet surveys rout ....Family business and succession planning: dynamics, barriers and strategies. This research will generate better strategies, protocols and policies for family business succession planning, tailored to the Australian context. Family businesses constitute about 70-80 per cent of Australian businesses, and $4.5 trillion in business value. It is estimated that $3.5 trillion of business value will change hands in the next decade as the post-war generation of business founders moves on. Yet surveys routinely show that family businesses indefinitely defer succession planning, placing businesses and their stakeholders at risk of acrimonious conflict and business failure. This research will contribute towards the National Research Priority goals strengthening Australia's social and economic fabric and ageing well, ageing productively.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Developing a data-based system for competitor analysis, performance monitoring, and decision-making within the disability employment service industry. There are three aims: to implement a database that would assist business decision-making and improvement of professional practices; to provide the peak body means for reporting to members, representing members to the funding body, and promoting the industry; to develop a system relevant to micro and small businesses across industries. Disability ....Developing a data-based system for competitor analysis, performance monitoring, and decision-making within the disability employment service industry. There are three aims: to implement a database that would assist business decision-making and improvement of professional practices; to provide the peak body means for reporting to members, representing members to the funding body, and promoting the industry; to develop a system relevant to micro and small businesses across industries. Disability employment services currently do not have means for competitor analysis even though it is recognised as integral to business planning. We expect that organisations will use the system, making more informed decisions, improving their performance, and improving their influence in discussions with the funding body.Read moreRead less
The Adoption of Information Technologies by Rural General Practitioners: A Socio-Technical Analysis. Many information technology (IT) products have been developed to support general practitioners (GPs) in aspects of their work (GPSRG, 1998). It is apparent that GPs are not making best use of these systems. The question is: if IT applications have been developed, why are GPs reluctant to use them? This study contrasts two approaches to innovation in researching the adoption of IT by rural gener ....The Adoption of Information Technologies by Rural General Practitioners: A Socio-Technical Analysis. Many information technology (IT) products have been developed to support general practitioners (GPs) in aspects of their work (GPSRG, 1998). It is apparent that GPs are not making best use of these systems. The question is: if IT applications have been developed, why are GPs reluctant to use them? This study contrasts two approaches to innovation in researching the adoption of IT by rural general practitioners. It aims to identify and model socio-technical factors that enable and inhibit the uptake of IT.
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