Resolving Human Immunodeficiency Virus (HIV) Transmission
Funder
National Health and Medical Research Council
Funding Amount
$745,213.00
Summary
To increase the breadth of HIV prevention strategies, it is imperative that we biologically understand how HIV enters our bodies. Through two unique clinical cohorts, we will determine why circumcision is protective and how a commonly acquired sexual transmitted infection (human papilloma virus) can increase HIV transmission.
Promoting Knowledge Economy Organisations and Innovative Work: Regional influences on Knowledge-based Small and Medium-sized Enterprise clusters in Australia and Germany. In both Australia and Germany many regional areas have experienced economic and social decline. Clusters offer a means of fostering local economic development thereby arresting regional social and economic deterioration. The research focuses on those clusters that rely on knowledge transfer between organisations. Through identi ....Promoting Knowledge Economy Organisations and Innovative Work: Regional influences on Knowledge-based Small and Medium-sized Enterprise clusters in Australia and Germany. In both Australia and Germany many regional areas have experienced economic and social decline. Clusters offer a means of fostering local economic development thereby arresting regional social and economic deterioration. The research focuses on those clusters that rely on knowledge transfer between organisations. Through identifying the drivers and impediments to the formation of knowledge based clusters, the research aims to provide practical guidance to regionally-based organizations to assist in the successful formation and maintenance of clusters. In doing so, the research will identify how clusters that rely on the sharing of organizational knowledge may promote greater regional employment possibilities.Read moreRead less
Environmental and Social Responsibility in the Small and Medium Sized Enterprise Sector: Challenges and Prospects. The proposed research addressed two of the National Research Priorities, viz., promoting an environmentally sustainable Australia (Goal 2: Transforming existing industries), and promoting and maintaining good health (Goal 4: strengthening Australia's social and economic fabric). The research findings will identify best practices in the areas of environmental and social responsibili ....Environmental and Social Responsibility in the Small and Medium Sized Enterprise Sector: Challenges and Prospects. The proposed research addressed two of the National Research Priorities, viz., promoting an environmentally sustainable Australia (Goal 2: Transforming existing industries), and promoting and maintaining good health (Goal 4: strengthening Australia's social and economic fabric). The research findings will identify best practices in the areas of environmental and social responsibility in the SME sector thus contributing to the creation of environmentally and socially sustainable workplaces. By integrating perspectives from multiple stakeholders the research also addresses community environmental and social concerns.Read moreRead less
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Exploring The Role Of Respiratory Virus Infections In Childhood Asthma Exacerbations
Funder
National Health and Medical Research Council
Funding Amount
$596,649.00
Summary
The PEAK study will explore the reasons children get worse asthma symptoms when they get colds. These reasons examined include the asthma medications taken (or not taken), allergies and exposure to allergens and the type of virus involved. The study follows the children over the whole school term and uses a new way to sample virus by collecting it in the breath, this is more comfortable than old methods and can be done at home.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.